Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway DOI Creative Commons

Tianlan Li,

Yiwa Liu,

Jingyi Cao

и другие.

Environment International, Год журнала: 2025, Номер 198, С. 109428 - 109428

Опубликована: Апрель 1, 2025

Triphenyl phosphate (TPHP) is a widely used organic flame retardant that has been reported as potential environmental obesogen. However, the impact and mechanism of action TPHP on adipose tissue are still unclear. This study investigates lipid metabolism disorders through in vivo vitro experiments. Male female BALB/c mice were exposed to (0, 1, 10, 150 mg/kg/day) for 60 days, 3T3-L1 preadipocytes treated with concentrations 0.1, 10 μM) during differentiation. The results showed exposure could cause gender specific dyslipidemia, male exhibiting dose-dependent increases inguinal coefficient, adipocyte hypertrophy, upregulation differentiation adipogenesis-related genes. In contrast, did not show significant changes morphology. suggested might promote occurrence adiposity by disrupting homeostasis tissue. During maturation process preadipocytes, led increased accumulation disrupted simultaneous activation adipogenesis lipolysis. Multiple omics data peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway fatty acid was core induced metabolic dysfunction. Further research activated PI3K/AKT pathway, PI3K inhibitor (LY294002) rescue droplet formation normalize expression adipogenic markers. These findings confirm obesogen can disrupt white PPARγ pathways, higher susceptibility males. provides compelling evidence obesogenic effects information risk assessment organophosphorus retardants.

Язык: Английский

The European Partnership PARC’s Role in Actively Promoting the Uptake of New Approach Methodologies and Next-Generation Risk Assessment into Regulatory Risk Assessment Practice DOI Creative Commons
Matthias Herzler, Mirjam Luijten, Philip Marx‐Stoelting

и другие.

Current Opinion in Toxicology, Год журнала: 2025, Номер unknown, С. 100517 - 100517

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway DOI Creative Commons

Tianlan Li,

Yiwa Liu,

Jingyi Cao

и другие.

Environment International, Год журнала: 2025, Номер 198, С. 109428 - 109428

Опубликована: Апрель 1, 2025

Triphenyl phosphate (TPHP) is a widely used organic flame retardant that has been reported as potential environmental obesogen. However, the impact and mechanism of action TPHP on adipose tissue are still unclear. This study investigates lipid metabolism disorders through in vivo vitro experiments. Male female BALB/c mice were exposed to (0, 1, 10, 150 mg/kg/day) for 60 days, 3T3-L1 preadipocytes treated with concentrations 0.1, 10 μM) during differentiation. The results showed exposure could cause gender specific dyslipidemia, male exhibiting dose-dependent increases inguinal coefficient, adipocyte hypertrophy, upregulation differentiation adipogenesis-related genes. In contrast, did not show significant changes morphology. suggested might promote occurrence adiposity by disrupting homeostasis tissue. During maturation process preadipocytes, led increased accumulation disrupted simultaneous activation adipogenesis lipolysis. Multiple omics data peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway fatty acid was core induced metabolic dysfunction. Further research activated PI3K/AKT pathway, PI3K inhibitor (LY294002) rescue droplet formation normalize expression adipogenic markers. These findings confirm obesogen can disrupt white PPARγ pathways, higher susceptibility males. provides compelling evidence obesogenic effects information risk assessment organophosphorus retardants.

Язык: Английский

Процитировано

0