Опубликована: Окт. 18, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Янв. 19, 2024
The global burden of cancer continues to rise, underscoring the urgency developing more effective and precisely targeted therapies. This comprehensive review explores confluence precision medicine CDC25 phosphatases in context research. Precision medicine, alternatively referred as customized aims customize medical interventions by taking into account genetic, genomic, epigenetic characteristics individual patients. identification particular genetic molecular drivers driving helps both diagnostic accuracy treatment selection. utilizes sophisticated technology such genome sequencing bioinformatics elucidate differences that underlie proliferation cells, hence facilitating development therapeutic interventions. phosphatases, which play a crucial role governing progression cell cycle, have garnered significant attention potential targets for treatment. dysregulation is characteristic feature observed various types malignancies, classifying them proto-oncogenes. proteins question, operate activation Cyclin-dependent kinases (CDKs), so promoting advancement cycle. inhibitors demonstrate drugs specifically blocking activity CDKs modulating cycle malignant cells. In brief, presents potentially fruitful option augmenting research, diagnosis, treatment, with an emphasis on individualized care predicated upon patients’ profiles. highlights significance identifies promising candidates intervention. statement underscores doing thorough profiling order uncover complex
Язык: Английский
Процитировано
10
Parasites & Vectors, Год журнала: 2024, Номер 17(1)
Опубликована: Май 16, 2024
Volatile organic compounds (VOCs) are chemicals emitted as products of cell metabolism, which reflects the physiological and pathological conditions any living organisms. These play a key role olfactory cues for arthropod vectors such mosquitoes, sand flies, ticks, act in transmission pathogens to many animal species, including humans. Some VOCs may influence behaviour, e.g., host preference oviposition site selection gravid females. Furthermore, deadly vector-borne Plasmodium falciparum Leishmania infantum suggested manipulate profile make them more attractive mosquitoes fly vectors, respectively. Under above circumstances, studies on these have demonstrated their potential usefulness investigating behavioural response ticks toward vertebrate hosts, well tools diagnosis diseases (VBDs). Herein, we provide an account scientific data available study seeking behaviour attractants, repellents, or early VBDs.
Язык: Английский
Процитировано
7
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 5, 2024
Abstract Background Bladder cancer is a common malignancy with high recurrence rate. Early diagnosis and surveillance are pivotal to patients’ outcomes, which require novel minimal-invasive diagnostic tools. The urinary microbiome associated bladder can be used as biomarkers, but the underlying mechanism fully illustrated performance improved. Methods A total of 23 treatment-naïve patients 9 non-cancerous subjects were enrolled into Before group Control group. After surgery, 10 from further assigned Void mid-stream urine samples collected sent for 16S rDNA sequencing, targeted metabolomic profiling, flow cytometry. Next, correlations analyzed between microbiota, metabolites, cytokines. Finally, receiver operating characteristic (ROC) curves biomarkers plotted compared. Results Comparing group, levels IL-6 ( p < 0.01), IL-8 0.05), IL-10 0.05) remarkably elevated in α diversity was also significantly higher, feature microbiota positively correlated level (r = 0.58, 0.01). Significant differences metabolic composition observed groups, fatty acids acylcarnitines enriched tumor resection, cytokine overall structure remained similar that reduced 0.05). Pathway enrichment analysis revealed beta-oxidation involved 0.001). ROC showed biomarker panel Actinomycetaceae + arachidonic acid had superior performance, sensitivity 0.94 specificity 1.00. Conclusions Microbiome dysbiosis, proinflammatory environment altered metabolism pathogenesis cancer, may throw light on noninvasive tool development.
Язык: Английский
Процитировано
4
Food Chemistry, Год журнала: 2025, Номер 479, С. 143767 - 143767
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Metabolomics, Год журнала: 2024, Номер 20(5)
Опубликована: Окт. 7, 2024
Язык: Английский
Процитировано
2
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 29, 2024
Bladder cancer is a significant health concern worldwide, necessitating effective diagnostic and monitoring strategies. Biomarkers play crucial role in the early detection, prognosis, treatment of this disease. This review explores current landscape bladder biomarkers, including FDA-approved molecular biomarkers emerging ones. such as BTA stat, TRAK, NMP22, have been instrumental diagnosing cancer. These are derived from urinary samples particularly useful due to their sensitivity specificity. As we move forward, should continue seek ways optimize our processes outcomes, these markers remain seriously challenged detection limited For instance, sensitivities stat tumor varied between 40-72%, while its specificities vary 29-96%. In same way, 70% 80% specificity recorded for 11-85.7% 77-100% documented NMP22 BladderChek. The given variations, especially low diagnosis at an stage call invention better systems. Moreover, different sample collection handling procedures applied laboratories further contribute inconsistent results obtained. Extracellular vesicles (EVs) exosomes, which carry vast number proteins, being considered potential biomarkers. Although show promise, challenges non-standardized isolation techniques lack reproducibility across studies. discovery new ongoing. UBC
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(24), С. 17543 - 17543
Опубликована: Дек. 16, 2023
Bladder cancer (BC) stands as one of the most prevalent urological malignancies, with over 500 thousand newly diagnosed cases annually. Treatment decisions in BC depend on factors like risk recurrence, type tumor, and stage disease. While standard therapeutic approaches encompass transurethral resection bladder radical cystectomy, chemo- or immunotherapy, these methods exhibit limited efficacy mitigating aggressive recurrent nature tumors. To overcome this challenge, it is crucial to develop innovative for monitoring predicting treatment responses among patients BC. Metabolomics gaining recognition a promising approach discovering biomarkers. It has potential reveal metabolic disruptions that precisely reflect how respond particular treatments, providing revolutionary method improve accuracy outcomes. In article, we present comprehensive review studies employing metabolomics investigate associated different modalities The encompasses an exploration various models, samples, analytical techniques applied context. Special emphasis placed reported changes metabolite levels derived from studies, highlighting their biomarkers personalized medicine
Язык: Английский
Процитировано
4
Critical Reviews in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 20
Опубликована: Июль 8, 2024
Bladder cancer (BC) is the tenth most common globally, predominantly affecting men. Early detection and treatment are crucial due to high recurrence rates poor prognosis for advanced stages. Traditional diagnostic methods like cystoscopy imaging have limitations, leading exploration of noninvasive such as liquid biopsy. This review highlights application biosensors in BC, including electrochemical optical sensors detecting tumor markers proteins, nucleic acids, other biomolecules, noting their clinical relevance. Emerging therapeutic approaches, antibody-drug conjugates, targeted therapy, immunotherapy, gene also explored, role corresponding biomarkers guide these treatments examined. Finally, addresses current challenges future directions biosensor applications highlighting need large-scale trials integration technologies deep learning enhance accuracy efficacy.
Язык: Английский
Процитировано
1
Scientia Sinica Vitae, Год журнала: 2024, Номер 54(8), С. 1439 - 1453
Опубликована: Июль 8, 2024
Процитировано
0
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
0