Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling DOI Creative Commons
Y. Liu, Jianxujie Zheng, Lingyan Zhong

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Hypertension, the leading cause of cardiovascular disease and premature mortality, is characterized by increased vessel stretch alterations in vascular smooth muscle cells (VSMCs). In this study, a vessel-on-a-chip model developed to simulate both physiological pathological conditions alongside mouse hypertension. Proteomics analysis applied investigate changes VSMCs using system compared these findings with data from model. The results demonstrates that enhances expression contractile markers VSMCs. Additionally, chip effectively replicates cellular responses stress, including upregulation ERK signaling, calcium ion transport pathway, integrin signaling endoplasmic reticulum toll-like receptor activation, oxidative synthesis sphingolipids ceramides. These indicate successfully mimics vivo biological events associated holds promise for advancing study vessel-related diseases facilitating development novel hypertension therapeutics.

Язык: Английский

Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling DOI Creative Commons
Y. Liu, Jianxujie Zheng, Lingyan Zhong

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Hypertension, the leading cause of cardiovascular disease and premature mortality, is characterized by increased vessel stretch alterations in vascular smooth muscle cells (VSMCs). In this study, a vessel-on-a-chip model developed to simulate both physiological pathological conditions alongside mouse hypertension. Proteomics analysis applied investigate changes VSMCs using system compared these findings with data from model. The results demonstrates that enhances expression contractile markers VSMCs. Additionally, chip effectively replicates cellular responses stress, including upregulation ERK signaling, calcium ion transport pathway, integrin signaling endoplasmic reticulum toll-like receptor activation, oxidative synthesis sphingolipids ceramides. These indicate successfully mimics vivo biological events associated holds promise for advancing study vessel-related diseases facilitating development novel hypertension therapeutics.

Язык: Английский

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