International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10090 - 10090
Опубликована: Сен. 19, 2024
The
emergence
of
antibiotic-resistant
Streptococcus
pneumoniae
necessitates
the
discovery
novel
therapeutic
agents.
This
study
investigated
antimicrobial
potential
green-synthesized
gold
nanoparticles
(AuNPs)
fabricated
using
Arthrospira
platensis
extract.
Characterization
Fourier
transform
infrared
spectroscopy
revealed
presence
functional
groups
such
as
ketones,
aldehydes,
and
carboxylic
acids
in
capping
agents,
suggesting
their
role
AuNP
stabilization.
Transmission
electron
microscopy
demonstrated
formation
rod-shaped
AuNPs
with
a
mean
diameter
134.8
nm,
determined
by
dynamic
light
scattering,
zeta
−27.2
mV,
indicating
good
colloidal
stability.
synthesized
exhibited
potent
antibacterial
activity
against
S.
pneumoniae,
minimum
inhibitory
concentration
(MIC)
12
μg/mL,
surpassing
efficacy
control
antibiotic,
tigecycline.
To
elucidate
underlying
mechanisms
action,
an
untargeted
metabolomic
analysis
A.
extract
was
performed,
identifying
26
bioactive
compounds
belonging
to
diverse
chemical
classes.
In
silico
studies
focused
on
molecular
docking
simulations
that
compound
22
strong
binding
affinity
topoisomerase
IV,
critical
enzyme
for
bacterial
DNA
replication.
Molecular
dynamics
further
validated
stability
this
protein–ligand
complex.
These
findings
collectively
highlight
promising
platensis-derived
constituent
compounds,
warranting
investigation
development
anti-pneumococcal
therapeutics.
Therapeutic Delivery,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Март 20, 2025
Aim
This
study
focuses
on
the
synthesis
and
evaluation
of
innovative
gold
nanoparticles
(AuNps)
stabilized
by
short-chain
ferulic
acid
(FA),
specifically
4-hydroxy-3-methoxy-cinnamic
acid.
Chemosensors,
Год журнала:
2025,
Номер
13(4), С. 130 - 130
Опубликована: Апрель 4, 2025
This
article
outlines
the
method
of
creating
electrodes
for
electrochemical
sensors
using
hybrid
nanostructures
composed
graphene
and
conducting
polymers
with
insertion
gold
nanoparticles.
The
technology
employed
dispersion
support
stabilization
was
based
on
chemical
vapor
deposition
technique
followed
by
delamination.
used
to
obtain
from
conductive
drop-casting,
utilizing
solutions
P3HT,
PANI-EB,
F8T2.
Additionally,
nanoparticles
utilized
an
innovative
dip-coating
technique,
graphene-conducting
polymer
frameworks
submerged
in
a
HAuCl4/2-propanol
solution
subsequently
subjected
controlled
heating.
integration
differs
notably,
P3HT
showing
least
adhesion
nanoparticles,
while
PANI-EB
exhibits
highest.
An
inkjet
printer
create
metallization
accomplished
through
use
commercial
silver
ink.
Notable
variations
roughness
(grain
size)
result
unique
behaviors
these
structures,
therefore,
any
potential
differences
sensitivity
generated
sensing
structures
can
be
more
thoroughly
understood
this
spatial
arrangement.
experiments
diluted
sulfuric
acid
at
three
different
scan
rates.
oxidation
reduction
potentials
seem
fairly
alike.
Nevertheless,
notable
difference
is
seen
anodic
cathodic
current
densities,
which
appear
largely
influenced
active
surface
linked
polymeric
grains.
graphene–PANI-EB
structure
Au
showed
highest
responsiveness
will
further
evaluated
biomedical
applications.
Polymers,
Год журнала:
2025,
Номер
17(8), С. 1024 - 1024
Опубликована: Апрель 10, 2025
Gold
nanoparticles–cuprous
oxide/reduced
graphene
oxide/polypyrrole
(AuNPs-Cu2O/rGO/PPy)
hybrid
nanocomposites
were
synthesized
for
surface
acoustic
wave
(SAW)
sensors,
achieving
high
sensitivity
(2
Hz/ppb),
selectivity,
and
fast
response
(~2
min)
at
room
temperature.
The
films,
deposited
via
spin-coating,
characterized
by
SEM,
EDS,
XRD,
revealing
a
rough,
wrinkled
morphology
beneficial
gas
adsorption.
sensor
showed
significant
frequency
shifts
to
NH3,
enhanced
AuNPs,
Cu2O,
rGO,
PPy.
It
had
6.4-fold
stronger
NH3
compared
CO2,
H2,
CO,
confirming
excellent
selectivity.
linear
detection
range
was
12–1000
ppb,
with
limit
of
(LOD)
8
ppb.
Humidity
affected
performance,
causing
negative
shifts,
declined
after
30
days
due
resistivity
changes.
Despite
this,
the
demonstrated
selectivity
stability
across
multiple
cycles.
In
simulated
breath
tests,
it
distinguished
between
healthy
patient-like
samples,
highlighting
its
potential
as
reliable,
non-invasive
diagnostic
tool.
