Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Ferroptosis
is
a
novel
form
of
cell
death
characterized
by
unlimited
accumulation
iron-dependent
lipid
peroxides.
It
often
accompanied
disease,
and
the
relationship
between
ferroptosis
immune
cells
regulation
has
been
attracting
increasing
attention.
Initially,
it
was
found
in
cancer
research
that
inhibition
regulatory
T
(Treg)
promotion
CD8+
jointly
promoted
formation
an
immune-tolerant
environment
tumors.
T-cell
subsequently
to
have
immunoregulatory
effects
other
diseases.
As
autoimmune
disease
imbalance,
attracted
attention
for
its
potential
regulating
balance
lupus
nephritis.
This
article
reviews
metabolic
processes
within
different
subsets
nephritis
(LN),
including
follicular
helper
(TFH)
cells,
(Th)17
Th1
Th2
Treg
reveals
these
cellular
metabolisms
not
only
facilitate
imbalance
but
are
also
closely
associated
with
occurrence
ferroptosis.
Consequently,
we
hypothesize
targeting
pathways
could
become
direction
effectively
treating
altering
differentiation
incidence
Redox Biology,
Год журнала:
2024,
Номер
73, С. 103176 - 103176
Опубликована: Апрель 30, 2024
Excitotoxicity
is
a
prevalent
pathological
event
in
neurodegenerative
diseases.
The
involvement
of
ferroptosis
the
pathogenesis
excitotoxicity
remains
elusive.
Transcriptome
analysis
has
revealed
that
cytoplasmic
reduced
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
levels
are
associated
with
susceptibility
to
ferroptosis-inducing
compounds.
Here
we
show
exogenous
NADPH,
besides
being
reductant,
interacts
N-myristoyltransferase
2
(NMT2)
and
upregulates
N-myristoylated
suppressor
protein
1
(FSP1).
NADPH
increases
membrane-localized
FSP1
strengthens
resistance
ferroptosis.
Arg-291
NMT2
critical
for
NADPH-NMT2-FSP1
axis-mediated
suppression
This
study
suggests
plays
pivotal
role
by
bridging
neuronal
We
propose
mechanism
which
regulates
N-myristoylation,
important
implications
disease
treatment.
Brain Research Bulletin,
Год журнала:
2024,
Номер
213, С. 110991 - 110991
Опубликована: Май 31, 2024
Neurodegenerative
diseases
such
as
Parkinson's
disease
(PD)
have
complex
pathogenetic
mechanisms.
Genetic,
age,
and
environmental
factors
are
all
related
to
PD.
Due
the
unclear
pathogenesis
of
PD
lack
effective
cure
methods,
it
is
urgent
find
new
targets
for
treating
patients.
Ferroptosis
a
form
cell
death
that
reliant
on
iron
exhibits
distinct
morphological
mechanistic
characteristics
compared
other
types
death.
It
encompasses
range
biological
processes,
including
iron/lipid
metabolism
oxidative
stress.
In
recent
years,
research
has
found
ferroptosis
plays
crucial
role
in
pathophysiological
processes
neurodegenerative
stroke.
Therefore,
also
closely
PD,
This
article
reviews
core
mechanisms
elucidates
correlation
between
ferroptosis.
addition,
compounds
emerged
years
exert
anti
effects
by
inhibiting
signaling
pathway
were
summarized.
I
hope
further
elaborate
relationship
through
review
this
article,
provide
strategies
developing
treatments
targeting
BioTechniques,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Фев. 20, 2025
Both
bacterial
and
eukaryotic
ribosomes
can
initiate
protein
synthesis
with
formylmethionine
(fMet),
but
detecting
fMet-bearing
peptides
proteins
has
been
challenging
due
to
the
lack
of
effective
anti-pan-fMet
antibodies.
Previously,
we
developed
a
polyclonal
anti-fMet
antibody
using
fMet-Gly-Ser-Gly-Cys
pentapeptide
that
detects
those
regardless
their
sequence
context.
In
this
study,
significantly
improved
antibody's
specificity
affinity
by
mixture
fMet-Xaa-Cys
tripeptides
(Xaa,
any
20
amino
acids)
as
immunogen.
This
newly
optimized
is
powerful,
cost-effective
tool
for
across
species.
Furthermore,
approach
provides
foundation
developing
anti-pan-specific
antibodies
targeting
other
N-terminal
modifications
through
acylation,
alkylation,
oxidation,
arginylation,
etc.
