DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity DOI Creative Commons

Yuki Ikeda,

Ryuzaburo Yuki, Youhei Saito

и другие.

The FASEB Journal, Год журнала: 2024, Номер 38(24)

Опубликована: Дек. 13, 2024

Abstract SUMOylation, the modification of proteins with a small ubiquitin‐like modifier (SUMO), is known to regulate various cellular events, including cell division. This process dynamic, its status depending on balance between SUMOylation and deSUMOylation. While regulation division by sentrin‐specific protease (SENP) family through deSUMOylation has been investigated, role another deSUMOylase, deSUMOylating isopeptidase 1 (DESI1), remains unknown. In this study, we explored DESI1's in Knockdown DESI1 accelerated progression, leading significant increase abnormal chromosome segregation. These phenotypes were rescued re‐expression wild‐type DESI1, but not catalytically inactive DESI1. knockdown reduced mitotic arrest caused nocodazole, suggesting involvement spindle assembly checkpoint (SAC). Localization Aurora B, key SAC regulator, at metaphase chromosomes was due decreased B expression upon knockdown. Consistently, transcription FoxM1 target genes, such as cyclin B1, CENP‐F. The TCGA database showed that both increased levels are associated poor prognosis patients certain cancer types. Importantly, found sensitivity vincristine inducing slippage. results suggest required for faithful segregation via regulating transcriptional activity thereby an activity‐dependent manner. Our findings identified novel regulator factor affecting chemotherapy.

Язык: Английский

Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses DOI Creative Commons
Lucía Sánchez-Alba,

Helena Borràs-Gas,

Ge Huang

и другие.

Trends in Biochemical Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1
The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy DOI Creative Commons

Bahejuan Jiaerken,

Wei Liu, Jiaojiao Zheng

и другие.

Biomedicines, Год журнала: 2024, Номер 12(10), С. 2408 - 2408

Опубликована: Окт. 21, 2024

(1) Background: Small ubiquitin-like modifiers (SUMOs) are pivotal in post-translational modifications, influencing various cellular processes, such as protein localization, stability, and genome integrity. (2) Methods: This review explores the SUMO family, including its isoforms catalytic cycle, highlighting their significance regulating key biological functions thyroid cancer. We discuss multifaceted roles of SUMOylation DNA repair mechanisms, modulation receptor activities, particularly context (3) Results: The aberrant machinery contributes to tumorigenesis through altered gene expression immune evasion mechanisms. Furthermore, we examine therapeutic potential targeting pathways cancer treatment, emphasizing need for further research develop effective inhibitors. (4) Conclusions: By understanding intricate biology, can pave way innovative strategies improve outcomes patients with advanced tumors.

Язык: Английский

Процитировано

1
Exploring potential targets for natural product therapy of DN: the role of SUMOylation DOI Creative Commons
Jingjing Wang, Rui Zhang,

Chenguang Wu

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 4, 2024

Diabetic nephropathy (DN) is a common and serious micro-vascular complication of diabetes leading cause end-stage renal disease globally. This primarily affects middle-aged elderly individuals, especially those with history over 10 years poor long-term blood glucose control. Small ubiquitin-related modifiers (SUMOs) are group reversible post-translational modifications proteins that widely expressed in eukaryotes. SUMO intervene the progression DN by modulating various signaling cascades, such as Nrf2-mediated oxidative stress, NF-κB, TGF-β, MAPK pathways. Recent advancements indicate natural products regulating SUMOylation hold promise targets for intervening DN. In previous article published 2022, we reviewed mechanisms which intervenes fibrosis presented summary some therapeutic potential. Therefore, this paper will focus on The aim review to elucidate mechanism action related potential, thereby summarising candidate treatment through modulation SUMOylation, ginkgolic acid, ginkgolide B, resveratrol, astragaloside IV, etc., highlighting product-mediated potential strategy strategy.

Язык: Английский

Процитировано

0
Antiviral defense in agedCaenorhabditis elegansdeclines due to loss of DRH-1/RIG-I deSUMOylation via ULP-4/SENP7 DOI Open Access
Yun Zhang, Andrew V. Samuelson

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Innate host defense mechanisms require posttranslational modifications (PTM) to protect against viral infection. Age-associated immunosenescence results in increased pathogenesis and mortality the elderly, but contribution of altered PTM regulation is unknown. SUMOylation a rapid reversible post-translational modification that has been implicated age-associated disease plays conflicting roles replication antiviral defenses mammals. We have discovered

Язык: Английский

Процитировано

0
Unravelling the molecular interplay: SUMOylation, PML nuclear bodies and vascular cell activity in health and disease DOI Creative Commons
Janine Berkholz,

Weronika Karle

Cellular Signalling, Год журнала: 2024, Номер 119, С. 111156 - 111156

Опубликована: Апрель 2, 2024

In the seemingly well-researched field of vascular research, there are still many underestimated factors and molecular mechanisms. recent years, SUMOylation has become increasingly important. is a post-translational modification in which small ubiquitin-related modifiers (SUMO) covalently attached to target proteins. Sites where these SUMO processes take place cell nucleus PML nuclear bodies (PML-NBs) - multiprotein complexes with their essential main component organizer, protein. SUMO, either alone or as partners, influence variety cellular processes, including regulation transcription, senescence, DNA damage response defence against microorganisms, involved innate immunity inflammatory responses. They also play an important role maintaining homeostasis system pathological leading development progression cardiovascular diseases. This review summarizes information about function SUMO(ylation) PML(-NBs) human vasculature from angiogenesis disease highlights clinical potential drug targets.

Язык: Английский

Процитировано

0
Bone Marrow Stromal Cells Protect Myeloma Cells from Ferroptosis through GPX4 deSUMOylation DOI Creative Commons
Hongmei Jiang, Qian Li,

Xudan Yang

и другие.

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217388 - 217388

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0
DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity DOI Creative Commons

Yuki Ikeda,

Ryuzaburo Yuki, Youhei Saito

и другие.

The FASEB Journal, Год журнала: 2024, Номер 38(24)

Опубликована: Дек. 13, 2024

Abstract SUMOylation, the modification of proteins with a small ubiquitin‐like modifier (SUMO), is known to regulate various cellular events, including cell division. This process dynamic, its status depending on balance between SUMOylation and deSUMOylation. While regulation division by sentrin‐specific protease (SENP) family through deSUMOylation has been investigated, role another deSUMOylase, deSUMOylating isopeptidase 1 (DESI1), remains unknown. In this study, we explored DESI1's in Knockdown DESI1 accelerated progression, leading significant increase abnormal chromosome segregation. These phenotypes were rescued re‐expression wild‐type DESI1, but not catalytically inactive DESI1. knockdown reduced mitotic arrest caused nocodazole, suggesting involvement spindle assembly checkpoint (SAC). Localization Aurora B, key SAC regulator, at metaphase chromosomes was due decreased B expression upon knockdown. Consistently, transcription FoxM1 target genes, such as cyclin B1, CENP‐F. The TCGA database showed that both increased levels are associated poor prognosis patients certain cancer types. Importantly, found sensitivity vincristine inducing slippage. results suggest required for faithful segregation via regulating transcriptional activity thereby an activity‐dependent manner. Our findings identified novel regulator factor affecting chemotherapy.

Язык: Английский

Процитировано

0