Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 9, 2024
Cancers arise from genetic and epigenetic abnormalities that affect oncogenes tumor suppressor genes, compounded by gene mutations. The N6-methyladenosine (m
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Март 27, 2024
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding pathophysiology, inspiring development therapeutics. As a crucial component epigenetics at post-transcription level, RNA modification significantly determines fates, further affecting various biological processes cellular phenotypes. To be noted, immunometabolism defines the metabolic alterations occur on immune cells different stages immunological contexts. In this review, we characterize distribution features, modifying mechanisms functions 8 modifications, including N6-methyladenosine (m6A), N6,2'-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N4-acetylcytosine (ac4C), N7-methylguanosine (m7G), Pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing, which are relatively most studied types. Then regulatory roles these diverse health disease contexts comprehensively described, categorized as glucose, lipid, amino acid, mitochondrial metabolism. And highlight regulation modifications immunometabolism, influencing responses. Above all, provide thorough discussion about clinical implications metabolism-targeted therapy immunotherapy, progression modification-targeted agents, its potential RNA-targeted Eventually, give legitimate perspectives for future researches field from methodological requirements, mechanistic insights, to therapeutic applications.
Язык: Английский
Процитировано
32
Cell Death and Disease, Год журнала: 2024, Номер 15(1)
Опубликована: Янв. 13, 2024
Abstract Acute lung injury (ALI) as well its more severe form, acute respiratory distress syndrome (ARDS), frequently leads to an uncontrolled inflammatory response. N 6 -methyladenosine (m A) modification was associated with the progression of several diseases. However, role methyltransferase-like 14 (METTL14)-mediated m A methylation in ALI/ARDS remains unclear. Here, we reported increase overall expression levels and METTL14 circulating monocyte-derived macrophages recruited following ALI, which is correlated severity injury. We further demonstrated critical function activating NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome vitro mouse models ALI/ARDS, validated NLRP3 downstream target by RNA immunoprecipitation (MeRIP) RIP assays. Mechanistically, METTL14-methylated transcripts were subsequently recognized insulin-like growth factor 2 mRNA-binding (IGF2BP2), reader, stabilized mRNA. Furthermore, observed that IGF2BP2 knockdown diminished LPS-induced ALI mice downregulating expression. In summation, our study revealed molecular mechanism underlying pathogenesis involves METTL14-mediated activation dependent manner, thereby demonstrating potential promising biomarkers therapeutic targets for treatment.
Язык: Английский
Процитировано
13
Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and checkpoint blockade. Nevertheless, cells encounters formidable hurdles. Macrophages, serving pivotal link between innate adaptive immunity, play crucial roles phagocytosis, cytokine secretion, antigen presentation. Consequently, macrophage-targeted therapies have garnered significant attention. We aim to provide most cutting-edge insights future perspectives for therapies, fostering development novel effective treatments. To date, forefront strategies macrophage targeting encompass: altering their plasticity, harnessing CAR-macrophages, phagocytosis checkpoints. Macrophages are characterized by remarkable diversity offering unique therapeutic target. In this context, we critically analyze innovative aimed at transforming macrophages from M2 (tumor-promoting) M1 (tumor-suppressing) phenotype. Furthermore, delve into design principles, developmental progress, advantages CAR-macrophages. Additionally, illuminate challenges encountered checkpoints on propose potential overcome these obstacles.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
1
Redox Biology, Год журнала: 2024, Номер 76, С. 103321 - 103321
Опубликована: Авг. 19, 2024
Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.
Язык: Английский
Процитировано
6
Aging and Disease, Год журнала: 2023, Номер 15(1), С. 96 - 96
Опубликована: Май 23, 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that has complex genetic basis. Through advancements in screening, researchers have identified more than 40 mutant genes associated with ALS, some of which impact immune function. Neuroinflammation, abnormal activation cells and excessive production inflammatory cytokines the central nervous system, significantly contributes to pathophysiology ALS. In this review, we examine recent evidence on involvement ALS-associated dysregulation, specific focus cyclic GMP-AMP synthase (cGAS)-stimulator interferon (STING) signaling pathway N6-methyladenosine (m
Язык: Английский
Процитировано
13
International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114211 - 114211
Опубликована: Фев. 9, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Март 1, 2025
ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102901 - 102901
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 35(1), С. 62 - 73
Опубликована: Сен. 30, 2023
Язык: Английский
Процитировано
10