ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke

Biomedicines, Год журнала: 2024, Номер 12(12), С. 2830 - 2830

Опубликована: Дек. 13, 2024

Background: Ischemic stroke results from a disruption of cerebral blood flow. Adrenocorticotropic hormone (ACTH) serves as the basis for creation synthetic peptides neuroprotective agents therapy. Previously, using RNA-Seq we first revealed differential expressed genes (DEGs) associated with ACTH(4–7)PGP (Semax) and ACTH(6–9)PGP under ischemia conditions. Analysis was carried out at 4.5 h after transient middle artery occlusion (tMCAO) model in ipsilateral frontal cortex rat brain. Methods: Here, analyzed penumbra-associated rats actions same 24 tMCAO RNA-Seq. Results: 3774 DEGs (fold change > 1.5 Padj < 0.05) were identified conditions, whereas 1539 2066 Semax tMCAO. Furthermore, both significantly reduced expression distortions caused by 1171 immune neurosignaling pathways. Concomitantly, there 32 versus administration Besides, neurogenesis-, angiogenesis-, protein kinase- growth factor-related action. observed effect histological level brains Thus, here demonstrate transcriptome manifestation this effect. comparison previous data post-tMCAO time point showed that pattern peptide action on depends elapsed Conclusions: We more similar to than different it day At point, ACTH-like compensated brain gene profiles disrupted ischemia. our may be useful selecting effective structures future anti-stroke drugs appropriate post-stroke points their testing.

Язык: Английский

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Endocrine Disruption After Brain Injury

Oxford University Press eBooks, Год журнала: 2024, Номер unknown

Опубликована: Авг. 21, 2024

Abstract For a long time, most brain trauma research has focused on the male population because of their higher rate injury. However, this disparity in between sexes created gaps knowledge about pathophysiology disease females and contributed to misdiagnosis women likely failure therapeutics clinical trials. Steps are being taken mitigate disparity, but there many mechanisms injury that still require characterization identification females; one those is mitochondrial dysfunction. Mitochondria crucial for maintenance normal function have been shown drive secondary pathways following traumatic ischemic injuries. Of little literature available, studies found mitochondria from more resilient compared males. Female sex hormones, like estrogen progesterone, modulate under non-pathological conditions, much learn process pathological after Historically, thought be neuroprotective against stroke. Preclinical can minimize infarct volume experimental stroke through mitochondrial-specific mechanisms. The field knows even less differences dysfunction how hormones may influence these processes. This chapter will discuss interplay hormone regulation implications personalized medicine trial development.

Язык: Английский

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Crosstalk between brain and the endocrine system

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 155 - 176

Опубликована: Окт. 1, 2024

Язык: Английский

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Biology and Pathology of Cortisol in Sexual Dysfunctions

Springer eBooks, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Янв. 1, 2024

Язык: Английский

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What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 22, 2024

Post-stroke stress can trigger instant survival but its influence on long-term ischemic stroke outcomes remains controversial. Thus, we sought to explore the associations of acute post-stroke evidenced by endocrine and metabolic changes, with outcomes. Admissions for within seven days onset were prospectively recruited determine variations measured thyroid parameters hyperglycemia ratio (SHR). Long-term prognoses followed up one year, primary outcome being a modified Rankin Scale score 3 6. A total 887 patients enrolled, which 535 reached final one-year at poor prognosis rate 29.3%. Patients observed have lower levels free triiodothyronine (fT3) higher SHR admission. Medium values (fT3, 4.4 mmol/L; SHR, 8 nmol/L) used divide into four gradient degrees. Larger (fT3 < mmol/L ≥ independently associated (adjusted OR = 4.231, P 0.001). High degrees may aggravate timely stress-reduced interventions help promote living quality is equally important as survival.

Язык: Английский

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Acute Endocrine and Metabolic Alterations and Long-Term Stroke Prognosis: Neuroprotection or Neuro-Destruction?

Опубликована: Янв. 1, 2023

Post-stroke stress reactions can trigger instant survival but their influence on long-term stroke outcomes may be variable. Thus, we sought to explore the associations of acute attacks, evidenced by endocrine and metabolic changes, with outcomes.Admissions for ischemic within seven days onset were prospectively recruited determine variations measured thyroid parameters hyperglycemia ratio (SHR). Long-term prognoses followed up one year, primary outcome being a modified Rankin Scale score 3 6.A total 887 patients enrolled in this study, which 535 year poor prognosis rate 29.3%. Patients one-year observed have lower levels free triiodothyronine (fT3) higher SHR. Medium values (fT3, 4.4 mmol/L; SHR, 0.8 mmol/L*%) used divide into four gradient degrees. Larger (fT3 < mmol/L SHR ≥ independently associated (adjusted OR = 4.231, P 0.001).High degrees attacks aggravate prognosis, timely stress-reduced interventions help promote post-stroke qualified living that is equally important as survival.Funding: This work was supported National Natural Science Foundation China (grant number 81901273) Technology Department Zhejiang Province Q21H090076).Declaration Interest: The authors stated explicitly there are no conflicts interest connection article.Ethical Approval: Ethical Decision Committee Research Administration at First Affiliated Hospital Wenzhou Medical University approved study (2021- R077). And all agreed participate use clinic data information research purposes.

Язык: Английский

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