bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 1, 2023
Circadian
desynchrony
induced
by
shiftwork
or
jetlag
is
detrimental
to
metabolic
health,
but
how
synchronous/desynchronous
signals
are
transmitted
among
tissues
unknown.
Here
we
report
that
liver
molecular
clock
dysfunction
signaled
the
brain
via
hepatic
vagal
afferent
nerve
(HVAN),
leading
altered
food
intake
patterns
corrected
ablation
of
HVAN.
Hepatic
branch
vagotomy
also
prevents
disruptions
high-fat
diet
feeding
and
reduces
body
weight
gain.
Our
findings
reveal
a
previously
unrecognized
homeostatic
feedback
signal
relies
on
synchrony
between
control
circadian
patterns.
This
identifies
vagus
as
therapeutic
target
for
obesity
in
setting
chrono-disruption.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Summary
Microglia,
the
brain’s
immune
cells,
are
highly
responsive
to
their
local
environment.
Given
that
circulatory
proteins
can
enter
brain,
we
asked
whether
microglia
such
proteins.
Here,
identify
a
stable
population
of
specialized
take
up
in
region-specific
manner
under
physiological
conditions;
human
hematopoietic
stem
cell-derived
replacing
endogenous
chimeric
mice
show
similar
regional
specialization.
Plasma-positive
characterized
by
prominent
expression
genes
related
innate
immunity
and
antigen
presentation
exhibit
high
metabolic
phagocytic
activity.
This
activity
is
dependent,
part,
on
microglial
uptake
accumulation
Apolipoprotein
AI
(ApoA-I).
Our
findings
thus
new
model
communication
between
brain
periphery
through
microglia.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 1, 2024
Abstract
Aging
affects
brain
structure
and
function
alongside
metabolic
vascular
processes
leading
to
energetic
impairments.
While
local
neurometabolic
dysfunction
in
aging
is
well-documented,
the
influence
of
systemic
cardiometabolic
markers
on
remains
less
understood.
We
examine
link
between
(measured
by
an
allostatic
load
index)
neurovascular
burden
white
matter
hyperintensities)
with
changes,
including
ventricular
hippocampal
volume,
as
well
EEG
activity,
across
age.
Analyzing
data
from
196
healthy
individuals
age
(20-75
years),
we
found
a
significant
positive
correlation
index
white-matter
hyperintensities,
irrespective
White-matter
hyperintensities
are
also
positively
linked
enlargement,
but
not
atrophy.
The
mediated
relationship
volume.
Regarding
function,
changes
spectral
aperiodic
exponent
periodic
alpha
power
were
index.
Such
hyperintensities.
Thus,
findings
suggest
that
state,
measured
index,
plays
crucial
role
health
age,
particularly
influencing
enlargement
increased
activity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 1, 2023
Circadian
desynchrony
induced
by
shiftwork
or
jetlag
is
detrimental
to
metabolic
health,
but
how
synchronous/desynchronous
signals
are
transmitted
among
tissues
unknown.
Here
we
report
that
liver
molecular
clock
dysfunction
signaled
the
brain
via
hepatic
vagal
afferent
nerve
(HVAN),
leading
altered
food
intake
patterns
corrected
ablation
of
HVAN.
Hepatic
branch
vagotomy
also
prevents
disruptions
high-fat
diet
feeding
and
reduces
body
weight
gain.
Our
findings
reveal
a
previously
unrecognized
homeostatic
feedback
signal
relies
on
synchrony
between
control
circadian
patterns.
This
identifies
vagus
as
therapeutic
target
for
obesity
in
setting
chrono-disruption.
