Integrative Analysis and Validation of a Cancer-associated Fibroblasts Senescence-related Signature for Risk Stratification and Therapeutic Prediction in Esophageal Squamous Cell Carcinoma

Journal of Cancer, Год журнала: 2024, Номер 15(17), С. 5742 - 5761

Опубликована: Янв. 1, 2024

Cellular senescence is closely associated with cancer development and progression. There ample evidence that tumor stromal cells, especially cancer-associated fibroblasts (CAFs) undergo in response to various stimuli. However, the possible biological roles prognostic significance of senescent CAFs esophageal squamous cell carcinoma (ESCC) remain unexplored. In this study, we found exhibited a significantly higher level cellular than other clusters at single-cell level. Then, constructed senescence-associated risk model 7 genes (

Язык: Английский

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Unraveling aging from transcriptomics

Trends in Genetics, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population‐based adult twin study

Aging Cell, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Abstract Several crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the contributions on these clocks change with age may provide novel insights into In this study, based 1084 adult twins from Chinese National Twin Registry (CNTR), we established structural equation models (SEMs) to evaluate trends in influence for epigenetic which include PC‐Horvath, PC‐Hannum, PC‐PhenoAge, PC‐GrimAge, and DunedinPACE. A decline overall heritability was observed all five ages 31 70, a relatively stable trend at first. Subsequently, apart other four displayed more evident drop heritability: DunedinPACE PC‐PhenoAge experienced clear between 55 65 years, while PC‐Horvath PC‐Hannum showed similar decrease 60 70 years. contrast, PC‐GrimAge remained throughout. An analysis methylation sites (CpGs) identified 41, 26, 4, 36 CpG potentially underlying changes DunedinPACE, respectively. Data CNTR were collected through two surveys 2013 2018. Based 308 longitudinal data, declines components follow‐up compared baseline, significant decreases PC‐clocks. peaked 5‐year contribution 55–60, PC‐clocks consistently 50–55. These findings offer role variations aging.

Язык: Английский

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Plasma triacylglycerol length and saturation level mark healthy aging groups in humans

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Язык: Английский

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