The effects of ketogenic metabolic therapy on mental health and metabolic outcomes in schizophrenia and bipolar disorder: a randomized controlled clinical trial protocol

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 21, 2024

Background Schizophrenia, schizoaffective disorder, and bipolar affective disorder are debilitating psychiatric conditions characterized by a chronic pattern of emotional, behavioral, cognitive disturbances. Shared psychopathology includes the pre-eminence altered states, disorders thoughts, behavioral control. Additionally, those share epidemiological traits, including significant cardiovascular, metabolic, infectious, respiratory co-morbidities, resulting in reduced life expectancy up to 25 years. Nutritional ketosis has been successfully used treat range neurological preclinical data have convincingly shown potential for its use animal models psychotic disorders. More recent from open clinical trials pointed toward dramatic reduction psychotic, affective, metabolic symptoms both schizophrenia disorder. Objectives investigate effects nutritional via modified ketogenic diet (MKD) over 14 weeks stable community patients with or schizophrenia. Design A randomized placebo-controlled trial 100 non-hospitalized adult participants diagnosis who capable consenting willing change their diets. Intervention Dietitian-led medically supervised compared following Australian Guide Healthy Eating weeks. Outcomes The primary outcomes include measures, reported as symptom improvement functional changes Positive Negative Symptoms Scale (PANSS), Young Mania Rating (YMS), Beck Depression Inventory (BDI), WHO Disability Schedule, Affect Lability Cambridge Cognitive Battery. secondary body weight, blood pressure, liver kidney function tests, lipid profiles, markers insulin resistance. Ketone glucose levels will be study correlation between outcomes. Optional hair cortisol analysis assess long-term stress variations fecal microbiome composition. Autonomic nervous system activity measured wearable devices (OURA ring EMBRACE wristband) form skin conductance, oximetry, continuous pulse monitoring, rate, movement tracking, sleep quality. Based on encouraging results established research, other neurodevelopment disorders, schizophrenia, we predict that therapy well tolerated result improved global measures social functioning. We additionally may exist level achieved cognitive, intervention group.

Язык: Английский

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Dietary Patterns, Gut Microbiota and Sports Performance in Athletes: A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(11), С. 1634 - 1634

Опубликована: Май 26, 2024

The intestinal tract of humans harbors a dynamic and complex bacterial community known as the gut microbiota, which plays crucial role in regulating functions such metabolism immunity human body. Numerous studies conducted recent decades have also highlighted significant potential microbiota promoting health. It is widely recognized that training nutrition strategies are pivotal factors allow athletes to achieve optimal performance. Consequently, there has been an increasing focus on whether dietary patterns influence sports performance through their impact microbiota. In this review, we aim present concept primary explore relationship between exercise specifically examine popular associated with athletes' while considering interaction Finally, discuss mechanisms by affect from nutritional perspective, aiming elucidate intricate interplay among patterns, We found precise application specific (ketogenic diet, plant-based high-protein Mediterranean high intake carbohydrate) can improve vascular function reduce risk illness health promotion, etc., well recovery controlling weight regard improving performance, etc. conclusion, although it be inferred certain aspects athlete's ability may benefit mediated some extent, further high-quality clinical warranted substantiate these claims underlying mechanisms.

Язык: Английский

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Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February – 2 March, 2024 (2024Pdm3)

European Journal of Translational Myology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 2, 2024

During the 2023 Padua Days on Muscle and Mobility Medicine 2024 meeting was scheduled from 28 February to 2 March (2024Pdm3). autumn program expanded with Scientific Sessions which will take place over five days (in this includes 29), starting afternoon of 27 in Conference Rooms Hotel Petrarca, Thermae Euganean Hills (Padua), Italy. As per consolidated tradition, second day Padua, for occasion Sala San Luca Monastery Santa Giustina Prato della Valle, Confirming attractiveness Medicine, 100 titles were accepted until 15 December (many more than expected), forcing organization parallel sessions both 1 2024. The include lectures oral presentations scientists clinicians Argentina, Austria, Belgium, Brazil, Bulgaria, Canada, Denmark, Egypt, France, Germany, Iceland, Ireland, Italy, Romania, Russia, Slovenia, Switzerland, UK USA. Only Australia, China, India Japan are missing edition. But we confident that authors those countries who publish articles PAGEpress: European Journal Translational Myology (EJTM: 2022 ESCI Clarivate's Impact Factor: 2.2; SCOPUS Cite Score: 3.2) decide join us coming years. Together established by 31 January 2024, abstracts circulate during only electronic version EJTM Issue 34 (1) See you soon person at Petrarca Montegrotto Terme, inauguration or on-line free via Zoom. Send your email address if not traditional participants listed Pdm3 books.

Язык: Английский

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The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats

Biology, Год журнала: 2025, Номер 14(2), С. 158 - 158

Опубликована: Фев. 4, 2025

Epilepsy, a brain condition causing recurrent seizures, can disrupt various body functions, including urination. This study explored how alternate-day fasting (ADF), type of intermittent fasting, diet involving one day eating and subsequently affects urinary system health in epileptic rats. Using genetic rat model epilepsy, we examined bladder kidney function through tissue analysis, biochemical tests, physiological assessments, focusing on differences between males females. The results showed that epilepsy causes significant damage linked to inflammation oxidative stress. However, ADF reduces this by lowering restoring antioxidant balance. Male rats exhibited more damage, while female responded better ADF, likely due hormonal differences. These findings suggest as potential, cost-effective dietary approach protect against complications similar conditions. Understanding these effects may lead improved treatments for both genders quality life people with chronic diseases.

Язык: Английский

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The U-Shaped Curve of Energy Supply in the First 72 Hours of Critical Illness May Apply Only to Patients with Normal Body Mass Index: A Post-Hoc Analysis of a Prospective Observational Multicenter Study

Опубликована: Янв. 1, 2025

Язык: Английский

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The Influence of Physical Exercise, Ketogenic Diet, and Time-Restricted Eating on De Novo Lipogenesis: A Narrative Review

Nutrients, Год журнала: 2025, Номер 17(4), С. 663 - 663

Опубликована: Фев. 13, 2025

De novo lipogenesis (DNL) is a metabolic pathway that converts carbohydrates into fatty acids, primarily occurring in the liver and, to lesser extent, adipose tissue. While hepatic DNL highly responsive dietary carbohydrate intake and regulated by insulin via transcription factors like SREBP-1c, more modest less sensitive overfeeding. Dysregulated contributes disorders, including dysfunction-associated steatotic disease (MASLD). Lifestyle interventions, such as physical exercise, ketogenic diets, time-restricted eating (TRE) offer promising strategies regulate improve health. Physical exercise enhances glucose uptake muscles, reduces levels, promotes lipid oxidation, thereby suppressing DNL. Endurance resistance training also mitochondrial function, further mitigating triglyceride accumulation. Ketogenic diets shift energy metabolism toward acid oxidation ketogenesis, lower insulin, directly downregulate lipogenic enzyme activity liver. TRE aligns feeding with circadian rhythms optimizing AMP-activated protein kinase (AMPK) activation during fasting periods, which suppresses metabolism. The combined effects of these interventions demonstrate significant potential for improving profiles, reducing triglycerides, preventing lipotoxicity. By addressing distinct roles DNL, target systemic localized dysregulation. Although research needed fully understand their long-term impact, findings highlight transformative integrating approaches clinical practice manage disorders associated complications.

Язык: Английский

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The U-shaped Curve of Energy Supply in the First 72 Hours of Critical Illness May Apply Only to Patients with Normal Body Mass Index: A Post-hoc Analysis of a Prospective Observational Multicenter Study

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Objective Nutritional support is crucial for critically ill patients. Body mass index (BMI) represents nutritional reserves to some extent, but it unclear whether the U-shaped relationship between caloric delivery during acute phase of critical illness and prognosis applies patients across all BMI categories. Methods This secondary analysis a multicenter prospective observational study, which included who were admitted intensive care unit (ICU) at least 3 days. The divided into two subgroups based on BMI: normal overweight (BMI > 25 kg/m²). We used univariate multivariate Cox regression analyses investigate calorie within first 72 hours ICU admission 28-day mortality, explore non-linear exists two. Results A total 361 in final analysis, including 272 subgroup 89 subgroup. In regression, there was significant (P = 0.003) association 0.002) daily delivered calories mortality. Increasing from 0 18 kcal/kg/day associated with decreasing mortality (hazard ratio (HR) 0.892, 95% CI 0.816–0.975), while increasing (HR 1.116, 1.016–1.227)); subgroup, higher also observed increase 1.124, 1.043–1.211, P 0.003), this disappeared (P 0.466). After adjustment, above results still hold up. Conclusions only those < kg/m², no such curve kg/m². Further research needed validate conclusion.

Язык: Английский

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The cyclic metabolic switching theory of intermittent fasting

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

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The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis

Journal of Food Science, Год журнала: 2025, Номер 90(3)

Опубликована: Март 1, 2025

Abstract Intermittent fasting (IF) is an eating pattern that promotes health and cognitive improvement through periodic eating. It has been shown to enhance neuroplasticity reduce oxidative stress inflammation. Recent studies have demonstrated probiotic supplementation enhances performance by modulating gut microbiota composition increasing short‐chain fatty acid production, which in turn neurogenesis synaptic plasticity. The microbiota‐gut‐brain axis (MGBA) the communication bridge between brain, influencing function immune, endocrine, nervous systems. combination of probiotics IF may exert complementary effects on function, with enhancing microbial diversity metabolic efficiency, while further modulate barrier integrity neurotransmitter synthesis. This review critically examines interplay via MGBA, identifying key mechanisms potential therapeutic strategies remain underexplored current research.

Язык: Английский

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Therapeutic effects of ketogenic diets on physiological and mental health

Опубликована: Март 25, 2025

Ketogenic diets are emerging dietary patterns that have demonstrated potential as therapeutic tools in a variety of symptoms and conditions, such epileptic seizures, diabetes, obesity, cancer, migraines, metabolic syndrome. This narrative review examines the effects ketogenic on physiological mental health, including their role modulating gut microbiome. promote weight loss, enhance insulin sensitivity, may lower dyslipidemia, which crucial factors preventing cardio-metabolic diseases. They also play significant composition function microbiome, serving approach to control autoimmune diseases, given effectiveness reducing pro-inflammatory cells. Conversely, downside these is decrease beneficial bacteria been positively associated with human health. Regarding capability stabilize neural networks, improve neuroplasticity, exert direct benefits brain bioenergetics, thereby potentially alleviating related several epilepsy, anxiety, depression, schizophrenia, bipolar disorder, autism spectrum certain neurodegenerative However, more randomized, long-term studies required assess efficacy, sustainability, safety, methodological rigor strengthen findings impacts.

Язык: Английский

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