Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery DOI Creative Commons
Keith A. Berggren, Saloni Sinha, Aaron E. Lin

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Abstract Modification of RNA with N 6 -methyladenosine (m A) has gained attention in recent years as a general mechanism gene regulation. In the liver, m A, along its associated machinery, been studied potential biomarker disease and cancer, impacts on metabolism, cell cycle regulation, pro-cancer state signaling. However these observational data have yet to be causally examined vivo. For example, neither perturbation key A writers Mettl3 Mettl14 , nor readers Ythdf1 Ythdf2 thoroughly mechanistically characterized vivo they vitro . To understand functions machineries, we developed mouse models found that deleting led progressive liver injury by nuclear heterotypia, changes mRNA splicing, processing export leading increases surveillance recycling.

Язык: Английский

Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription DOI Creative Commons
Andoni Gómez-Moreno, Alexander Ploß

Viruses, Год журнала: 2024, Номер 16(4), С. 609 - 609

Опубликована: Апрель 15, 2024

Hepatitis B virus (HBV) is the etiologic agent of chronic hepatitis B, which puts at least 300 million patients risk developing fibrosis, cirrhosis, and hepatocellular carcinoma. HBV a partially double-stranded DNA

Язык: Английский

Процитировано

10
RNA Modification in Metabolism DOI Creative Commons
Yadi Liu,

Zhongyan Sun,

Dingkun Gui

и другие.

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.

Язык: Английский

Процитировано

0
Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery DOI Creative Commons
Keith A. Berggren, Saloni Sinha, Aaron E. Lin

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Abstract Modification of RNA with N 6 -methyladenosine (m A) has gained attention in recent years as a general mechanism gene regulation. In the liver, m A, along its associated machinery, been studied potential biomarker disease and cancer, impacts on metabolism, cell cycle regulation, pro-cancer state signaling. However these observational data have yet to be causally examined vivo. For example, neither perturbation key A writers Mettl3 Mettl14 , nor readers Ythdf1 Ythdf2 thoroughly mechanistically characterized vivo they vitro . To understand functions machineries, we developed mouse models found that deleting led progressive liver injury by nuclear heterotypia, changes mRNA splicing, processing export leading increases surveillance recycling.

Язык: Английский

Процитировано

0