Resmetirom and Metabolic Dysfunction-Associated Steatohepatitis: Perspectives on Multidisciplinary Management from Global Healthcare Professionals

Current Obesity Reports, Год журнала: 2024, Номер 13(4), С. 818 - 830

Опубликована: Авг. 7, 2024

Язык: Английский

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Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Сен. 30, 2024

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease. Body mass index (BMI) used obesity but has important limitations. The weight-adjusted waist (WWI) a novel metric and accurately reflects body composition. We explored association of WWI with all-cause cardiovascular (CVD) mortality in MASLD. Methods Adult participants MASLD were included from NHANES 1999-2018. was calculated by dividing circumference (WC) square root weight. diagnosed presence hepatic steatosis at least one cardiometabolic risk factor absence other causes steatosis. A fatty ≥60 suggested Mortality data obtained prospectively linking to National Death Index. Multivariate Cox proportional hazards regression analyses explore these associations multiple adjustment models constructed including crude, partial, fully adjusted models. Results After adjusting for all covariates BMI, remained positively linearly associated CVD (hazard ratios [HR] 1.247 1.218, respectively). Higher significantly increased (both p trend <0.05). There an “obesity paradox” between BMI MASLD, lower those overweight/obesity compared normal (HR 0.625 0.596, respectively, = 0.024), no mortality. Interaction indicated that influenced several demographic variables status. Time-dependent receiver operating characteristic curves predictive value higher than WC, waist-to-height ratio across follow-up durations. Conclusions whereas did not reflect risk. provided optimal traditional indicators. These findings emphasize potential use as indicator assessment, stratification, prevention

Язык: Английский

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Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Год журнала: 2024, Номер 17(1), С. 143 - 143

Опубликована: Дек. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Язык: Английский

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Namodenoson at the Crossroad of Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma

Biomedicines, Год журнала: 2024, Номер 12(4), С. 848 - 848

Опубликована: Апрель 11, 2024

Namodenoson (CF102) is a small, orally available, anti-inflammatory, and anti-cancer drug candidate currently in phase 2B trial for the treatment of metabolic dysfunction-associated steatohepatitis (MASH; formerly known as non-alcoholic (NASH)) 3 pivotal clinical hepatocellular carcinoma (HCC). In both MASH HCC, mechanism-of-action namodenoson involves targeting A3 adenosine receptor (A3AR), resulting deregulation downstream signaling pathways leading to inhibition inflammatory cytokines (TNF-α, IL-1, IL-6, IL-8) stimulation positive (G-CSF adiponectin). Subsequently, liver inflammation, steatosis, fibrosis were documented experimental models, HCC growth was observed vitro, vivo, studies. This review discusses evidence related multifaceted mechanism action namodenoson, how this reflected available data HCC.

Язык: Английский

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Serum bile acid profiles are associated with heart failure with preserved ejection fraction in patients with metabolic dysfunction‐associated fatty liver disease: An exploratory study

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(9), С. 3684 - 3695

Опубликована: Июнь 14, 2024

Abstract Aim To analyse the association between serum bile acid (BA) profile and heart failure (HF) with preserved ejection fraction (HFpEF) in patients metabolic dysfunction‐associated fatty liver disease (MAFLD). Methods We enrolled 163 individuals biopsy‐proven MAFLD undergoing transthoracic echocardiography for any indication. HFpEF was defined as left ventricular >50% at least one echocardiographic feature of HF (left diastolic dysfunction, abnormal atrial size) sign or symptom. Serum levels 38 BAs were analysed using ultra‐performance liquid chromatography coupled tandem mass spectrometry. Results Among (mean age 47.0 ± 12.8 years, 39.3% female), 52 (31.9%) 43 (26.4%) met pre‐HFpEF criteria, detected. ursodeoxycholic (UDCA) hyocholic (HCA) species lower achieved statistical significance after correction multiple comparisons. Furthermore, decreases glycoursodeoxycholic tauroursodeoxycholic associated status. Conclusions In this exploratory study, specific UDCA HCA status adults biopsy‐confirmed MAFLD.

Язык: Английский

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