Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 17, 2024

Once thought to be in a terminally differentiated state, macrophages are now understood highly pliable, attuned and receptive environmental cues that control align responses. In development of purpose, the centrality metabolic pathways has emerged. Thus, macrophage inflammatory or reparative phenotypes tightly linked catabolic anabolic metabolism, with further fine tuning specific gene expression patterns settings. Single-cell transcriptome analyses have revealed breadth signatures, some new influencers driving phenotype. CD36/Scavenger Receptor B2 established roles immunity lipid metabolism. Macrophage CD36 is key functional player profiles determine Emerging data show alterations microenvironment can recast modulate function, potential leveraged for therapeutic means. This review covers recent on phenotypic characterization homeostatic, atherosclerotic, lipid-, tumor- metastatic-associated macrophages, integral role highlighted.

Язык: Английский

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Olfr2+ macrophages: monocyte-derived, pro-inflammatory foamy-like cells in atherosclerosis

Cardiovascular Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Язык: Английский

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