Research Progress on the Effects of Iron on Human Body

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 645 - 650

Опубликована: Янв. 1, 2025

Язык: Английский

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Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis

FASEB BioAdvances, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Inflammatory bowel diseases are chronic inflammatory conditions with growing prevalence in western populations. Iron is an essential component of erythrocytes hemoglobin. Under the influence elevated hepcidin production, iron sequestered cells during inflammation which, turn, leads to restriction for red blood cell synthesis. As a consequence, deficiency and anemia most prevalent extraintestinal complications IBD patients. commonly treated oral supplements, limited efficacy as absorption blunted intestinal inflammation. Moreover, supplementation can cause complications, previous studies have shown that it worsen response. However, comparative analysis effects low, adequate, high dietary content matching given patients has not been performed mice. We therefore tested impact deprivation murine model colitis induced by dextran sodium sulfate. found both were accompanied more severe earlier signs gastrointestinal bleeding compared mice fed iron‐adequate diet. The manipulation led profound dysbiosis colon control differed depending on content. Analysis this line pronounced susceptibility colonic inflammation, thus questioning benefit/risk balance

Язык: Английский

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Targeting Siderophore Biosynthesis to Thwart Microbial Growth

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3611 - 3611

Опубликована: Апрель 11, 2025

The growing threat of antibiotic resistance has made treating bacterial and fungal infections increasingly difficult. With the discovery new antibiotics slowing down, alternative strategies are urgently needed. Siderophores, small iron-chelating molecules produced by microorganisms, play a crucial role in iron acquisition serve as virulence factors many pathogens. Because is essential for microbial survival, targeting siderophore biosynthesis transport presents promising approach to combating drug-resistant infections. This review explores key genetic biochemical mechanisms involved production, emphasizing potential drug targets within these pathways. Three major biosynthetic routes examined: nonribosomal peptide synthetase (NRPS)-dependent, polyketide synthase (PKS)-based, NRPS-independent (NIS) Additionally, uptake membrane-associated systems discussed, providing insights into their sustaining pathogenic growth. Recent advances inhibitor development have shown that blocking critical enzymes can effectively impair By disrupting pathways, antimicrobial be developed, offering alternatives traditional potentially reducing risk resistance. A deeper understanding its regulation not only reveals fundamental processes but also provides foundation designing targeted therapeutics. Leveraging could lead novel drugs overcome resistance, hope fight against persistent

Язык: Английский

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Pulling back the mitochondria’s iron curtain

npj Metabolic Health and Disease, Год журнала: 2025, Номер 3(1)

Опубликована: Март 4, 2025

Язык: Английский

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Composition, Properties, and Beneficial Effects of Functional Beverages on Human Health

Beverages, Год журнала: 2025, Номер 11(2), С. 40 - 40

Опубликована: Март 14, 2025

Functional beverages comprise a special category of drinks free alcohol that contain bioactive components from plant, animal, marine, or microorganism sources contribute to the reinforcement human health. are mainly divided into following basic categories: (i) dairy-based and (ii) non-dairy-based beverages. have several positive functional properties such as rehydration body, recovery lost energy, increase athletic performance, prevention pain in joints, improvement heart health, immunity digestive system, creation feeling satiety boosting mood. However, according health experts, there also induce obesity diseases because their high content sugars, sweeteners, other caffeine, taurine, taurine combined with creatinine, etc. The scope this review was highlight main energy along effects on Limited articles address overall hypothesis recent literature, thus comprising significance current study.

Язык: Английский

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Monitoring and Assessment of Exposure to Potentially Hazardous Particles in High-Risk Workplaces in the Production of Ni-Cd Batteries

Опубликована: Янв. 1, 2025

Язык: Английский

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Iron and Immunity

Опубликована: Апрель 4, 2025

Язык: Английский

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Regulation of Iron Trafficking in the Body

Опубликована: Апрель 4, 2025

Язык: Английский

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BIOMETALS IN NEURODEGENERATIVE DISEASES: THEIR BENEFICIAL AND DETRIMENTAL ROLES IN BRAIN HEALTH.

Greener Journal of Biomedical and Health Sciences, Год журнала: 2025, Номер 8(1), С. 16 - 27

Опубликована: Март 10, 2025

Biometals are essential to many physiological functions, including the normal functioning and development of brain. Notably, altered levels these biometals in body have been observed patients living with neurodegenerative conditions like Alzheimer’s, Huntington’s, Parkinson’s, Amyotrophic Lateral Sclerosis. This review will establish how can enter accumulate mechanisms for exhibiting neurotoxic effects. Correlations between level other non-essential metals existence diseases make them worthy study. Researchers looked toward biometal homeostasis as potential sources biomarkers, diagnostic breakthroughs, therapeutic solutions conditions. In addition, we explore benefit brain health, their role conditions, next frontiers biometal-based diagnostics therapy research.

Язык: Английский

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Rapid and precise quantification of lymphocyte iron content by single cell inductively coupled plasma mass spectrometry

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Abstract Metals facilitate catalysis during cellular metabolism, but heterogeneity of metal content at single-cell level within and between cell populations is poorly characterized. This important because deficiencies biometals, for example iron, are enormously prevalent worldwide. Here we quantify single-cells using inductively-coupled plasma mass spectrometry. To develop the method, used rhodium iridium-intercalated Jurkat cells, obtaining >0.96% r 2 cross-analytical correlation with cytometry. We quantified iron calcium mass/cell murine T-lymphocytes 3% 8% 2-sigma intra-precision, respectively, when assessing thousands cells/minute. exposed to a 625-fold difference in extracellular concentrations maintained close homeostatic control, varying ∼20% content. Nevertheless, this relatively small variation strongly correlated changes activation characteristics measured by flow also assessed human B-cell content, which was ∼10-fold higher than T-lymphocytes. Overall, demonstrate rapid quantification different types relate function. Teaser Precise metallomics lymphocytes single ICP-MS powerful approach accessing signatures immunological status.

Язык: Английский

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