Indian Journal of Cardiovascular Disease in Women,
Год журнала:
2024,
Номер
0, С. 1 - 11
Опубликована: Дек. 26, 2024
Endocrine
disrupting
chemicals
(EDCs)
are
environmental
contaminants
that
interfere
with
the
hormonal
system,
posing
significant
risks
to
human
health.
Found
in
everyday
items
such
as
plastics,
pesticides,
cosmetics,
and
industrial
materials,
EDCs
include
both
persistent
chemicals,
for
example,
dichlorodiphenyltrichloroethane
(DDT),
polychlorinated
biphenyls
(PCBs),
per-
polyfluoroalkyl
substances
(PFAS)
non-persistent
ones,
bisphenol
A
(BPA),
phthalates,
parabens.
Mechanistically,
mimic
or
block
natural
hormones,
affecting
processes
glucose
metabolism,
lipid
insulin
signaling.
These
disruptions
elevate
risk
of
obesity,
type
2
diabetes
mellitus,
metabolic
syndrome,
cardiovascular
diseases,
especially
when
exposure
occurs
during
prenatal
early
life
stages.
The
detrimental
impact
extends
beyond
their
diabetogenic
obesogenic
effects.
BPA
heavy
metals
disrupt
estrogen
androgen
signaling,
leading
hypertension,
endothelial
dysfunction,
arterial
stiffness.
In
addition,
further
promote
oxidative
stress,
which
contributes
atherosclerosis
events.
significantly
reproductive
health,
causing
precocious
puberty,
infertility,
polycystic
ovarian
endometriosis,
uterine
fibroids
females
delayed
infertility
males.
health
ramifications
extend
individual
can
affect
ensuing
generations.
cause
epigenetic
changes
be
passed
down
future
generations,
compounding
long-term
on
quality
healthcare
spending.
Intrauterine
EDC
is
associated
profound
fetal
growth,
potentially
low
birth
weight
intrauterine
growth
restriction,
predispose
these
individuals
life-long
challenges.
Mitigation
requires
a
comprehensive
prevention
strategy
minimize
widespread
impacts,
starting
from
family
unit.
making
simple
swaps
daily
minimizing
use
plastic,
processed
food
items,
scrutinizing
paints
possible
presence
avoiding
direct
second-hand
smoking.
However,
broader
regulatory
actions
need
initiated
global
level
implement
stricter
safety
standards,
production
entry
into
ecosystem
exploring
safer
alternatives.
Toxics,
Год журнала:
2025,
Номер
13(3), С. 168 - 168
Опубликована: Фев. 27, 2025
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
a
group
of
environmental
contaminants
associated
with
various
health
risks;
however,
their
relationship
all-cause
mortality
in
individuals
diabetes
remains
unclear.
A
total
1256
participants
from
the
National
Health
Nutrition
Examination
Survey
(NHANES)
were
included
to
explore
association
between
seven
PFAS
compounds
diabetic
patients.
Preliminary
logistic
regression
identified
three
(perfluorooctanoic
acid
[PFOA],
perfluorooctane
sulfonic
[PFOS],
2-(N-methyl-PFOSA)
acetate
[MPAH])
as
significantly
population.
The
optimal
cut-off
values
for
PFOS,
PFOA,
MPAH
determined
using
X-tile
algorithm,
categorized
into
high-
low-exposure
groups.
Kaplan–Meier
survival
curves
multivariable
Cox
proportional
hazards
models
used
assess
levels
risk.
results
showed
that
high
PFOS
increased
risk
patients
(hazard
ratio
[HR]:
1.55,
95%
confidence
interval
[CI]:
1.06–2.29),
while
PFOA
no
significant
associations.
To
mechanisms
underlying
PFOS–mortality
link,
toxicogenomic
analysis
95
overlapping
genes
exposure
diabetes-related
Comparative
Toxicogenomics
Database
(CTD)
GeneCards.
Functional
enrichment
revealed
key
biological
processes,
such
glucose
homeostasis
response
peptide
hormone,
pathways
including
longevity
regulating
pathway,
apoptosis,
p53
signaling
pathway.
Protein–protein
interaction
network
10
hub
genes,
was
found
upregulate
or
downregulate
mRNA
expression,
protein
activity,
notable
effects
on
levels.
These
findings
suggest
contributes
through
related
metabolism,
cellular
signaling.
Our
study
provides
new
insights
diabetes,
highlighting
need
large-scale
cohort
studies
further
vivo
vitro
experiments
validate
these
findings.
Toxics,
Год журнала:
2025,
Номер
13(3), С. 187 - 187
Опубликована: Март 5, 2025
Chemicals
in
personal
care
and
consumer
products
are
suspected
to
disrupt
endocrine
function
affect
reproductive
health.
However,
the
link
between
mixed
exposure
long-term
amenorrhea
is
not
well
understood.
This
study
analyzed
data
from
684
women
(2013–2018
National
Health
Nutrition
Examination
Survey)
assess
eight
polyfluorinated
alkyl
substances
(PFASs),
15
phthalates
(PAEs),
six
phenols,
four
parabens.
Various
statistical
models
for
robustness
tests
mediation
analysis
were
used
explore
associations
with
role
of
serum
globulin.
Biological
mechanisms
identified
through
an
integrated
strategy
involving
target
key
chemicals
intersections,
pathway
analysis,
validation.
Results
showed
that
had
higher
levels
Perfluorodecanoic
acid,
Perfluorohexane
sulfonic
acid
(PFHxS),
Perfluorononanoic
n-perfluorooctanoic
(n_PFOA),
n-perfluorooctane
Perfluoromethylheptane
isomers.
Logistic
regression
different
adjustments
consistently
found
significant
elevated
PFAS
concentrations
increased
risk,
confirmed
by
Partial
Least
Squares
Discriminant
Analysis.
Mediation
revealed
globulin
partially
mediated
relationship
amenorrhea.
Network
suggested
PFHxS
n_PFOA
may
interact
Signal
Transducer
Activator
Transcription
3
(STAT3).
highlights
exposure,
particularly
n_PFOA,
amenorrhea,
STAT3
serving
as
mediators
underlying
mechanisms.
American Journal of Industrial Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
persistent
environmental
contaminants.
Previous
research
has
linked
PFAS
exposure
to
prostate
ovarian
cancer
risk,
however,
the
conclusions
have
been
inconsistent.
This
purpose
was
determine
relationship
between
at
population
level.
We
systematically
reviewed
three
databases-PubMed,
Web
of
Science,
Embase-for
from
when
these
databases
were
established
April
15,
2024.
The
quality
retrieved
evaluated
using
Newcastle-Ottawa
Scale
(NOS)
measurement
tool.
Meta-analysis
extracted
data
conducted
Stata
18.
also
sensitivity
subgroup
analyses,
as
well
Begg's
Egger's
tests.
Twelve
publications
involved
in
analysis
for
cancer,
six
included
ovary
cancer.
outcomes
indicated
that
PFOS
positively
related
(OR:
1.13,
95%
CI:
1.00-1.28),
while
mixed
1.63,
1.49-1.78).
source
heterogeneity
identified
primarily
attributable
variations
study
design.
No
significant
bias
detected
analysis.
demonstrated
an
association
both
cancers.
Further
investigation
is
required
clarify
underlying
mechanisms
potential
associations.
BMC Global and Public Health,
Год журнала:
2025,
Номер
3(1)
Опубликована: Апрель 8, 2025
Access
to
safe
and
nutritious
food
is
key
ensuring
health
well-being
critical
meeting
the
United
Nations'
Sustainable
Development
Goals.
However,
a
synthesis
of
associations
between
foodborne
illness
malnutrition,
such
as
metabolic
health,
remains
gap
in
literature
base.
In
this
review,
we
summarized
existing
evidence
on
impacts
biological
chemical
hazards
nutrition-related
outcomes,
specifically
overweight
obesity,
inflammation,
disease,
thyroid
function,
cancer
development,
adverse
birth
examining
physiological
mechanisms,
epidemiological
associations,
animal
studies.
Mechanisms
some
hazards,
H.
pylori,
pregnancy
e.g.,
gestational
diabetes
mellitus,
or
nitrates
impaired
are
relatively
well-studied.
effects
many
other
human
limited:
for
example,
while
arsenic
exposure
associated
with
limited
availability
dose-response
studies
challenges
limit
ascertaining
its
causal
role.
Untangling
these
mechanisms
high
relevance
both
high-
well
low-
middle-income
countries.
Emerging
technologies
novel
assessment
techniques
needed
improve
detection
understanding
understudied
complex
diseases,
particularly
those
arising
from
hazards.
These
gaps
highlighted
need
establishing
surveillance
systems
monitoring
diseases
outcomes
across
populations.
