Mitochondrion, Год журнала: 2025, Номер unknown, С. 102033 - 102033
Опубликована: Март 1, 2025
Язык: Английский
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Abstract Altered mitochondria biology can accelerate biological aging, but scalable biomarkers of mitochondrial health for population studies are lacking. We examined two potential candidates: 1) cell-free DNA (cf-mtDNA), a marker signaling elevated with disease states accessible as distinct entities from plasma or serum; and 2) growth differentiation factor 15 (GDF15), an established biomarker aging downstream energy transformation defects stress signaling. In cohort 430 participants aged 24-84 (54.2% women), we measured serum cf-mtDNA, GDF15 levels at timepoints 5 years apart, then assessed their associations age, BMI, diabetes, sex, health-related behaviors, psychosocial factors. As expected, showed positive, exponential association age (r=0.66, p<0.0001) increased by 33% over five years. cf-mtDNA was not correlated age. BMI sex were also related to nor GDF15. Type 2 diabetes only positively associated Exploring drivers systemic signaling, report novel linking higher education lower age-adjusted (r=-0.14, p<0.0034), both baseline the 5-year follow up, highlighting influence factors on health. Overall, our findings among adults spanning six decades lifespan establish between GDF15, emerging Further needed determine if blood metabolic be moderated behaviors.
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Abstract FGF21 is a metabolic hormone induced by fasting, stress, and mitochondrial oxidative phosphorylation (OxPhos) defects that cause diseases (MitoD). Here we report acute psychosocial stress alone (without physical exertion) decreases serum an average of 20% ( p <0.0001) in healthy controls but increases 32% people with MitoD—pointing to functional interaction between the response OxPhos capacity regulating FGF21. We further define co-activation patterns stress-related neuroendocrine hormones novel associations factors related wellbeing, highlighting potential role for meeting energetic needs chronic stress.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Growth differentiation factor 15 (GDF15) is a biomarker of energetic stress related to aging, disease, and mitochondrial defects. We recently showed that GDF15 quantifiable in saliva acutely inducible by psychosocial stress. To date, the associations between biopsychosocial factors individual characteristics remain unknown. Here, sample healthy working adults ( n = 198, 70% females), we first confirmed salivary reacts acute stress, peaking 10 min following socio-evaluative paradigm (+28.3%, g 0.50, p < 0.0001). then explored i) baseline ii) reactivity variety trait- state-level including sex gender characteristics; measures mental health, burnout; physical health behaviors; anthropometric blood-based metabolic biomarkers. Baseline was higher men than women positively correlated with testosterone, while negatively estrogen traditionally feminine roles. Of examined, found work-related variables were most consistently GDF15, cynicism, burnout, emotional exhaustion predicting reactivity, job-related autonomy utilization competence predicted smaller responses. Consistent GDF15's induction renal diseases, also indirect markers disease waist-to-hip ratio, creatinine, albumin. Finally, participants greater exhibited cortisol consistent role regulation energy mobilization. Together, this exploratory analysis suggest new biological correlates, calling for large-scale studies connecting human experiences
Язык: Английский
Процитировано
0
Mitochondrion, Год журнала: 2025, Номер unknown, С. 102033 - 102033
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0