Cited by Short-term methionine deprivation inhibits TCA cycle and regulates macrophage polarization through uncharged tRNA and PDHA1 phosphorylation

Engineering innate immune cells for cancer immunotherapy DOI

Mubin Tarannum,

Xizhong Ding,

Marta Barisa

и другие.

Nature Biotechnology, Год журнала: 2025, Номер 43(4), С. 516 - 533

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma DOI

Manman Yao,

Ying-Chun Lu,

Tiejun Liu

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 16, 2025

Oral Lichen Planus (OLP) is a chronic inflammatory disorder that may progress to Squamous Cell Carcinoma (OSCC). Lipid metabolism dysregulation has been implicated in tumor development and immune response modulation. This study aims explore the role of lipid metabolism, particularly lipids diacylglycerol (DAG), triacylglycerol (TAG), phosphatidylcholine (PC), progression from OLP OSCC, identify potential therapeutic targets for prevention treatment. We performed Mendelian randomization (MR) analysis investigate causal relationships between risk OSCC. Differential gene expression was conducted key genes related metabolism. The interactions species were examined using drug databases (DrugBank, DGIdb, TCMSP) candidates. Enrichment signaling pathways, including PPAR signaling, also understand underlying mechanisms. Our MR revealed DAG exerts protective effect (OR < 1), but its shifts factor OSCC > potentially by altering microenvironment. TAG PI plays critical tumorigenesis. Gene identified several metabolism-related genes, SLC27A6, FABP3, FABP4, ADIPOQ, PLIN1, whose differed highlighting their importance progression. These enriched pathway, suggesting involvement growth Potential candidates, such as palm acid (PA), Imatinib, Curcumin, through drug-repurposing strategies. crucial Targeting pathways DAG, TAG, PI, offer promising strategies early diagnosis intervention. provides novel insights into molecular mechanisms OLP-to-OSCC suggests natural compounds, future clinical applications. Further research needed validate these findings settings. Not applicable.

Язык: Английский

Процитировано

Short-term methionine deprivation inhibits TCA cycle and regulates macrophage polarization through uncharged tRNA and PDHA1 phosphorylation DOI

Xinyu Zhu, Zinan Wang, Xiaoyi Ye

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2025, Номер unknown, С. 109939 - 109939

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано