Hypothalamus-specific NSCs derived from hPSCs ameliorate age-associated dysfunction upon transplantation into aged mouse hypothalamus DOI
Yanuar Alan Sulistio, Yuna Lee,

Kelvin Pieknell

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 24, 2024

Abstract The hypothalamus is the brain region that regulates systemic body metabolism and multiple functions. adult harbors neural stem/precursor cell (NSC)-like cells. Along with age-related changes, hypothalamic NSC (htNSC) population declines, indicating potential of htNSC replacement as an anti-aging strategy. Here, we developed protocol to generate htNSCs from human pluripotent stem cells (hPSCs). Implanting hPSC-derived into aged mice ameliorated declines in metabolic fitness, physical capacity, cognitive function. Mechanistically, these effects were mediated by inter-tissue communication: enhanced neuronal activity htNSC-transplanted stimulated adipose tissues produce release molecule eNAMPT circulation via sympathetic nervous system. Concurrently, inflammatory environment was alleviated peripheral signals. Collectively, our findings support anti- or healthy aging therapies targeting hypothalamus.

Язык: Английский

Hypothalamus-specific NSCs derived from hPSCs ameliorate age-associated dysfunction upon transplantation into aged mouse hypothalamus DOI
Yanuar Alan Sulistio, Yuna Lee,

Kelvin Pieknell

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 24, 2024

Abstract The hypothalamus is the brain region that regulates systemic body metabolism and multiple functions. adult harbors neural stem/precursor cell (NSC)-like cells. Along with age-related changes, hypothalamic NSC (htNSC) population declines, indicating potential of htNSC replacement as an anti-aging strategy. Here, we developed protocol to generate htNSCs from human pluripotent stem cells (hPSCs). Implanting hPSC-derived into aged mice ameliorated declines in metabolic fitness, physical capacity, cognitive function. Mechanistically, these effects were mediated by inter-tissue communication: enhanced neuronal activity htNSC-transplanted stimulated adipose tissues produce release molecule eNAMPT circulation via sympathetic nervous system. Concurrently, inflammatory environment was alleviated peripheral signals. Collectively, our findings support anti- or healthy aging therapies targeting hypothalamus.

Язык: Английский

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