Organic Chemistry Frontiers, Год журнала: 2021, Номер 8(24), С. 6874 - 6880
Опубликована: Янв. 1, 2021
An asymmetric tandem cycloisomerization/[3 + 2] cycloaddition reaction of 2,2′-diester aziridine and 2-ethynyl benzyl alcohol with Au( i )/chiral N , ′-dioxide−Dy( iii ) as a relay catalyst system was developed.
Язык: Английский
Chemical Reviews, Год журнала: 2018, Номер 118(20), С. 10393 - 10457
Опубликована: Окт. 10, 2018
This review covers the use of 2-azaallyl anions, cations, and radicals in organic synthesis up through June 2018. Particular attention is paid to both foundational studies recent advances over past decade involving semistabilized nonstabilized anions as key intermediates various carbon–carbon carbon–heteroatom bond-forming processes. Both transition-metal-catalyzed transition-metal-free transformations are covered. Azomethine ylides, which have received significant elsewhere, discussed briefly with primary focus on critical comparisons regard generation use.
Язык: Английский
Процитировано
199
RSC Advances, Год журнала: 2016, Номер 6(58), С. 53203 - 53272
Опубликована: Янв. 1, 2016
In
this
review,
we
update
our
previous
presentation,
underscoring
the
recent
applications
of
isocyanides
as
privileged
synthons
in
synthesis
various
heterocyclic
compounds,
especially
focused
on
those
synthesized
Язык: Английский
Процитировано
162
RSC Advances, Год журнала: 2017, Номер 7(72), С. 45763 - 45783
Опубликована: Янв. 1, 2017
Recent developments in synthetic strategies towards functionalized azetidines along with their versatility as heterocyclic synthons.
Язык: Английский
Процитировано
89
Nature Communications, Год журнала: 2019, Номер 10(1)
Опубликована: Май 9, 2019
Abstract Although isocyanide-based multicomponent reactions were proven to be simple, elegant and facile strategies for the synthesis of highly valuable nitrogen-containing heterocycles, their asymmetric versions accessing optically active nitrogen heterocyclic compounds are rather limited. Here, we illustrate that, relying on enantioselective addition simple isocyanides C=C bonds, several realized in presence a chiral Mg II - N , ʹ-dioxide catalyst. In reaction among isocyanide, TMSN 3 alkylidene malonate, three- or four-component could precisely controlled by modulating conditions, supplying two types enantioenriched tetrazole-derivatives moderate high yields. Possible catalytic cycles via key zwitterionic intermediate, vital roles H 2 O excess ligand provided based control experiments. Moreover, taking advantage this intermediate as 1,3-dipole, an dearomative [3+2] annulation nonactivated isoquinolines is achieved, furnishing 1,2-dihydroisoquinolines good excellent results.
Язык: Английский
Процитировано
72
Chemical Science, Год журнала: 2016, Номер 7(6), С. 3775 - 3779
Опубликована: Янв. 1, 2016
An
enantioselective
[3
+
2]
annulation
of
donor–acceptor
aziridines
with
aldehydes
utilizing
a
relay
catalyst
system
Nd(OTf)3/
Язык: Английский
Процитировано
49
Advances in heterocyclic chemistry, Год журнала: 2019, Номер unknown, С. 245 - 335
Опубликована: Янв. 1, 2019
Язык: Английский
Процитировано
45
Topics in heterocyclic chemistry, Год журнала: 2015, Номер unknown, С. 49 - 142
Опубликована: Янв. 1, 2015
Язык: Английский
Процитировано
46
ACS Catalysis, Год журнала: 2017, Номер 7(6), С. 3934 - 3939
Опубликована: Май 4, 2017
A highly diastereo- and enantioselective [3 + 2] cycloaddition of 2,2′-diester aziridines with 3,4-dihydropyran derivatives acyclic enol ethers has been established. Various optically active octahydropyrano[2,3-c]pyrrole 3-methoxypyrrolidine were generated in moderate to high yields (up 94%) good stereoselectivities (>19:1 dr, up 95.5:4.5 er). The methodology was also applied the diastereoselective synthesis d-galactal derivatives. absolute configuration octahydropyrano[2,3-c]pyrroles showed that reactions using 6-alkyl-substituted ones as substrates gave reversed diastereoselection final cyclization step.
Язык: Английский
Процитировано
40
Advanced Synthesis & Catalysis, Год журнала: 2017, Номер 359(20), С. 3585 - 3591
Опубликована: Авг. 14, 2017
Abstract A silver‐catalyzed aerobic oxidative [3+2] cycloaddition of azomethine ylides with aryl or heteroaryl isocyanides has been developed. The reaction represents a novel protocol for the efficient and practical synthesis 1,2‐diarylimidazoles bearing broad range substituents in good to excellent yields under mild conditions. practicability this was shown by gram‐scale double construction highly conjugated polyarylimidazole systems. magnified image
Язык: Английский
Процитировано
36
Advances in heterocyclic chemistry, Год журнала: 2019, Номер unknown, С. 1 - 74
Опубликована: Ноя. 12, 2019
Язык: Английский
Процитировано
31