Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment

RSC Advances, Год журнала: 2025, Номер 15(5), С. 3756 - 3828

Опубликована: Янв. 1, 2025

Pyrazolo[1,5- a ]pyrimidines are notable class of heterocyclic compounds with potent protein kinase inhibitor (PKI) activity, playing critical role in targeted cancer therapy.

Язык: Английский

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1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

Molecules, Год журнала: 2022, Номер 27(7), С. 2237 - 2237

Опубликована: Март 30, 2022

Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which included in more 5500 references (2400 patents) up to date. This review will cover analysis diversity substituents present at positions N1, C3, C4, C5, C6, synthetic methods used for their synthesis, starting from both preformed pyrazole or pyridine, biomedical applications such compounds.

Язык: Английский

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The electrochemical coupling reactions of organic halides compound in a valuable and practical manner for C C and C–heteroatom formation: An overview

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(8), С. 105822 - 105822

Опубликована: Май 24, 2024

Owing to the environmental and energy problems nowadays, one of enormous challenges is expanding clean, renewable reduce destructive ecological effects chemical industries. Compared with other traditional processes, electrochemical method has some benefits, such as being selective, causing minor waste, working under mild conditions no external oxidizing or reducing reagents, making this approach more economical eco-friendly. Electrochemistry represents a powerful tool within synthetic organic chemistry. The development part chemistry intends performance reactions employing electrons, including adding removing electrons. Using electric current reagent advantages, simplicity reactions, accessibility materials, replacing toxic applying an eco-friendly environment. During last decades, there been much effort decrease usage fossil fuels, electricity emerged common source. conversion into leads new paths, naturally safe environmentally friendly. Developing electrochemistry approaches for performing high-performance essential reaction green strategy because utilization instead stoichiometric oxidants reductants. Due its helpful friendly ability produce reactive intermediates, advanced considerably in oxidative hydrogen evolution coupling sacrificial anode electroreduction. New developments focus on developing electrolytic catalysts,photoelectrocatalysis, bioelectrosynthesis, optimizing electrode paired electrolysis, artificial intelligence-assisted electrosynthesis. Thus, daily significant number construction projects possibilities electrochemistry. Electrochemical methods constructing compounds have tolerated renewal past decades. Organic wealthy background synthesis. We hope review helps attract attention from researchers by using processes laboratory industrial centers, which pollution create In review, organohalides synthesizing various products summarized discussed since 2000.

Язык: Английский

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Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

Applied Organometallic Chemistry, Год журнала: 2023, Номер 37(11)

Опубликована: Сен. 17, 2023

Heterocycles and barbituric acid analogs are particularly used in developing designing new drugs because of their versatile binding properties for different biotargets. They present many natural compounds, vitamins, drugs, biologically active molecules such as anticancer, antibiotic, antidiabetic, anti‐inflammatory, antidepressant, anti‐HIV, antimicrobial, insecticidal agents. Using co‐friendly techniques under nanocatalyst conditions drives the synthesis these bioactive compounds toward green chemistry. This review will investigate nanocatalysts, including magnetic nano metal‐based catalysts, organo‐nanocatalysts, metal–organic frameworks (MOFs) nanocatalysts employed design heterocyclic by acids from 2017 to 2022.

Язык: Английский

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Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

ChemistrySelect, Год журнала: 2024, Номер 9(28)

Опубликована: Июль 22, 2024

Abstract In the present era, concept of green in organic synthesis has a unique and irreplaceable place. Specifically, nanoparticle gained much more attention due to its various properties related chemistry. this context, magnetic been widely used over last one decade. Among compounds, pyrazole scaffolds are recognized as privileged structure it represents promising area for identification lead structures towards discovery new synthetic drug molecules other valuable candidates. Several commercial drugs such Sildenafil, Rimonabant, Celecoxib many compounds biological testing preclinical evaluation, illustrate wide therapeutic spectrum class scaffolds. Accordingly, nanoparticles have an place derivatives is easy methodology chemists. The manuscript assimilation literature pertaining aspects highly diversified pyrazole.

Язык: Английский

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Sodium alginate: A biopolymeric catalyst for the synthesis of novel and known polysubstituted pyrano[3,2-c]chromenes

International Journal of Biological Macromolecules, Год журнала: 2019, Номер 140, С. 605 - 613

Опубликована: Авг. 19, 2019

Язык: Английский

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Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles

Topics in Current Chemistry, Год журнала: 2023, Номер 381(4)

Опубликована: Май 26, 2023

Язык: Английский

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A Green, Organometallic Catalyzed Synthesis of a Series of Novel Functionalized 4‐Aroyl‐4H‐benzo[g]chromenes through One‐pot, Three Component Reaction

Journal of Heterocyclic Chemistry, Год журнала: 2018, Номер 55(4), С. 951 - 956

Опубликована: Фев. 9, 2018

A new series of 4‐aroyl‐4 H ‐benzo[ g ]chromene derivatives have been synthesized through an efficient, straightforward, and environmentally acceptable one‐pot, three component reaction malononitrile, different arylglyoxals, 2‐hydroxy‐1,4‐naphtoquinone (lawsone) in short times high to excellent yields. The zinc complex amino acid L‐proline, that is, Zn[L‐proline] 2 has prepared used as highly active, recyclable, noncorrosive, water soluble Lewis catalyst for this transformation.

Язык: Английский

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The multicomponent synthesis of urea substituted 2-arylfurans

Tetrahedron, Год журнала: 2022, Номер 111, С. 132716 - 132716

Опубликована: Март 5, 2022

Язык: Английский

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A Facile Synthesis of Xanthene‐1,8(2H)‐dione Derivatives by Using Tetrapropylammonium Bromide as Catalyst

Journal of Heterocyclic Chemistry, Год журнала: 2018, Номер 55(6), С. 1324 - 1330

Опубликована: Апрель 17, 2018

Several new derivatives of 9‐aroyl‐3,4,5,6,7,9‐hexahydro‐1 H ‐xanthene‐1,8(2 )‐dione have been synthesized in yields varying from high to excellent by the condensation reaction arylglyoxals with 1,3‐diketones (cyclohexane‐1,3‐dione or dimedone) and TPAB as an inexpensive, recoverable, non‐toxic catalyst presence ethanol/water under reflux conditions.

Язык: Английский

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