Synthesis of heterocyclic analogues based on biscyanoethyl derivative of fusidic acid methyl ester DOI
Е. В. Салимова, Lyudmila V. Parfenova

Журнал органической химии, Год журнала: 2023, Номер 59(12), С. 1637 - 1643

Опубликована: Дек. 15, 2023

Язык: Английский

A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents DOI Open Access
Tejas M. Dhameliya,

Shrddhaba J. Chudasma,

Tanvi M. Patel

и другие.

Molecular Diversity, Год журнала: 2022, Номер 26(5), С. 2967 - 2980

Опубликована: Янв. 5, 2022

Язык: Английский

Процитировано

50

Advances in the Application of Acetonitrile in Organic Synthesis since 2018 DOI Open Access
Pinyong Zhong, Linjun Zhang, Nianhua Luo

и другие.

Catalysts, Год журнала: 2023, Номер 13(4), С. 761 - 761

Опубликована: Апрель 16, 2023

Acetonitrile is commonly used as an organic solvent and can also be important intermediate in synthesis. Its widespread use has led to the development of new methods for synthesis a variety compounds. In past decades, conversion reactions acetonitrile building block have become one most-attractive fields Especially field electrochemical conversions involving acetonitrile, due its good conductivity environmentally friendly features, it powerful compelling tool afford nitrogen-containing compounds or nitrile-containing this review, we mainly discuss research progress five years, covering both conventional Besides, detailed discussion substrate scope mechanistic pathways provided.

Язык: Английский

Процитировано

21

A comprehensive review of recent advances in the biological activities of 1,2,4‐oxadiazoles DOI

Omnia M. Hendawy

Archiv der Pharmazie, Год журнала: 2022, Номер 355(7)

Опубликована: Апрель 21, 2022

Abstract Nitrogen heterocycles play an essential role in medication development. The 1,2,4‐oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules with varied biological functions. shows bioisosteric equivalency ester and amide moieties. In recent years, the nucleus received lot attention medicinal chemistry. It was thought to be pharmacophore component production biologically intriguing drugs. This review presents comprehensive overview achievements activities 1,2,4‐oxadiazoles as potential antimicrobial, anticancer, anti‐inflammatory, neuroprotective, antidiabetic agents. structure–activity relationship mechanisms action are also reviewed.

Язык: Английский

Процитировано

26

Electrochemical Synthesis of Polysubstituted Oxazoles from Ketones and Acetonitrile DOI

Liang Bao,

Chen Liu, Wenyi Li

и другие.

Organic Letters, Год журнала: 2022, Номер 24(31), С. 5762 - 5766

Опубликована: Авг. 1, 2022

Herein we report an electrochemical strategy for the construction of polysubstituted oxazoles from easily available ketones and acetonitrile under room temperature. The method shows high efficiency, a broad substrate scope, requires no external chemical oxidant. Mechanistic investigations suggest that reaction proceeds through Ritter-type reaction/oxidative cyclization using as reactant solvent. X-ray crystallographic analysis reveals involves attack on carbonyl carbon instead α-carbon.

Язык: Английский

Процитировано

26

Photocatalytic Benzylic C–H Oxidation/Cyclization of Enaminones to the Synthesis of Polysubstituted Oxazoles DOI
Mingrui Li,

Zhiqin He,

Wei Zhao

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(13), С. 8257 - 8267

Опубликована: Июнь 1, 2023

Photocatalytic benzylic C–H oxidation/cyclization of enaminones was efficiently achieved to afford oxazole derivatives under mild conditions. The oxygen in the ring originated from green oxidant molecular oxygen. synthetic protocol features broad substrate scopes and good functional group tolerance. combined experimental theoretical studies reveal that suit is involved reaction transformations.

Язык: Английский

Процитировано

13

Electrochemical oxidation-induced benzylic C(sp3)–H functionalization towards the atom-economic synthesis of oxazole heterocycles DOI
Na Yang, Anni Li, Hui Gao

и другие.

Green Chemistry, Год журнала: 2023, Номер 25(13), С. 5128 - 5133

Опубликована: Янв. 1, 2023

A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, nitriles, and water has been established in the absence any catalyst or external oxidant.

Язык: Английский

Процитировано

12

I2/TBHP-mediated oxidative cascade cyclization of vinyl azide and benzylamine to construct 2,5-disubstituted oxazoles DOI

Mohanreddy Pothireddy,

Rana Chatterjee, P. Vijaya Babu

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(27), С. 5521 - 5526

Опубликована: Янв. 1, 2023

An efficient metal-free synthesis of 2,5-disubstituted oxazoles has been developed from vinyl azide and benzylamine via C(sp 3 )–H functionalization oxidative cyclization.

Язык: Английский

Процитировано

10

Electrochemical Ammoxidation of Unprotected Glycosides DOI Creative Commons
Imke M. A. Bartels, Md Asmaul Hoque, K. Jeya Prathap

и другие.

ACS electrochemistry., Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0

PIFA-mediated room temperature dehydrogenative annulation for the synthesis of 2-alkenyl oxazoles DOI
Kang Chen, Jie‐Ping Wan,

Liyun Zhou

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1308, С. 138142 - 138142

Опубликована: Март 24, 2024

Язык: Английский

Процитировано

3

Organic Acid to Nitrile: A Chemoenzymatic Three‐Step Route DOI Creative Commons
Margit Winkler,

Melissa Horvat,

Astrid Schiefer

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2022, Номер 365(1), С. 37 - 42

Опубликована: Дек. 1, 2022

Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for whole range of different reactions. We report cyanide free chemoenzymatic cascade nitrile synthesis. The reaction pathway starts with reduction carboxylic acid to aldehyde by carboxylate reductase enzymes (CARs) living cell biocatalysts. second - step includes

Язык: Английский

Процитировано

12