Журнал органической химии, Год журнала: 2023, Номер 59(12), С. 1637 - 1643
Опубликована: Дек. 15, 2023
Язык: Английский
Molecular Diversity, Год журнала: 2022, Номер 26(5), С. 2967 - 2980
Опубликована: Янв. 5, 2022
Язык: Английский
Процитировано
50
Catalysts, Год журнала: 2023, Номер 13(4), С. 761 - 761
Опубликована: Апрель 16, 2023
Acetonitrile is commonly used as an organic solvent and can also be important intermediate in synthesis. Its widespread use has led to the development of new methods for synthesis a variety compounds. In past decades, conversion reactions acetonitrile building block have become one most-attractive fields Especially field electrochemical conversions involving acetonitrile, due its good conductivity environmentally friendly features, it powerful compelling tool afford nitrogen-containing compounds or nitrile-containing this review, we mainly discuss research progress five years, covering both conventional Besides, detailed discussion substrate scope mechanistic pathways provided.
Язык: Английский
Процитировано
21
Archiv der Pharmazie, Год журнала: 2022, Номер 355(7)
Опубликована: Апрель 21, 2022
Abstract Nitrogen heterocycles play an essential role in medication development. The 1,2,4‐oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules with varied biological functions. shows bioisosteric equivalency ester and amide moieties. In recent years, the nucleus received lot attention medicinal chemistry. It was thought to be pharmacophore component production biologically intriguing drugs. This review presents comprehensive overview achievements activities 1,2,4‐oxadiazoles as potential antimicrobial, anticancer, anti‐inflammatory, neuroprotective, antidiabetic agents. structure–activity relationship mechanisms action are also reviewed.
Язык: Английский
Процитировано
26
Organic Letters, Год журнала: 2022, Номер 24(31), С. 5762 - 5766
Опубликована: Авг. 1, 2022
Herein we report an electrochemical strategy for the construction of polysubstituted oxazoles from easily available ketones and acetonitrile under room temperature. The method shows high efficiency, a broad substrate scope, requires no external chemical oxidant. Mechanistic investigations suggest that reaction proceeds through Ritter-type reaction/oxidative cyclization using as reactant solvent. X-ray crystallographic analysis reveals involves attack on carbonyl carbon instead α-carbon.
Язык: Английский
Процитировано
26
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(13), С. 8257 - 8267
Опубликована: Июнь 1, 2023
Photocatalytic benzylic C–H oxidation/cyclization of enaminones was efficiently achieved to afford oxazole derivatives under mild conditions. The oxygen in the ring originated from green oxidant molecular oxygen. synthetic protocol features broad substrate scopes and good functional group tolerance. combined experimental theoretical studies reveal that suit is involved reaction transformations.
Язык: Английский
Процитировано
13
Green Chemistry, Год журнала: 2023, Номер 25(13), С. 5128 - 5133
Опубликована: Янв. 1, 2023
A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, nitriles, and water has been established in the absence any catalyst or external oxidant.
Язык: Английский
Процитировано
12
Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(27), С. 5521 - 5526
Опубликована: Янв. 1, 2023
An efficient metal-free synthesis of 2,5-disubstituted oxazoles has been developed from vinyl azide and benzylamine via C(sp 3 )–H functionalization oxidative cyclization.
Язык: Английский
Процитировано
10
ACS electrochemistry., Год журнала: 2025, Номер unknown
Опубликована: Май 15, 2025
Язык: Английский
Процитировано
0
Journal of Molecular Structure, Год журнала: 2024, Номер 1308, С. 138142 - 138142
Опубликована: Март 24, 2024
Язык: Английский
Процитировано
3
Advanced Synthesis & Catalysis, Год журнала: 2022, Номер 365(1), С. 37 - 42
Опубликована: Дек. 1, 2022
Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for whole range of different reactions. We report cyanide free chemoenzymatic cascade nitrile synthesis. The reaction pathway starts with reduction carboxylic acid to aldehyde by carboxylate reductase enzymes (CARs) living cell biocatalysts. second - step includes
Язык: Английский
Процитировано
12