Fine Chemical Technologies,
Год журнала:
2022,
Номер
17(5), С. 377 - 383
Опубликована: Ноя. 19, 2022
Objectives
.
To
study
the
patterns
of
behavior
morpholine
and
its
trimethylsilyl
derivative
in
reactions
with
isocyanate.
Methods
The
employed
infrared
nuclear
magnetic
resonance
spectroscopy,
as
well
elemental
analysis.
Results
formation
mixtures
tautomeric
forms
silicon-containing
urea—N-(trimethylsilyl)
morpholine-4-carboxamide
trimethylsilylmorpholine-4-carboximidoate—was
established.
Conclusions
It
is
shown
that
composition
structure
resulting
products
are
determined
both
by
presence
a
substituent
at
nitrogen
atom
type
isocyanate
used.
Unlike
morpholine,
itself
reacts
to
form
mixture
forms.
Trends in Chemistry,
Год журнала:
2023,
Номер
5(3), С. 174 - 200
Опубликована: Фев. 14, 2023
Organic
peroxides
are
becoming
popular
intermediates
for
novel
chemical
transformations.
The
weak
O-O
bond
is
readily
reduced
by
transition
metals,
including
iron
and
copper,
to
initiate
a
radical
cascade
process
that
breaks
C-C
bonds.
Great
potential
exists
the
rapid
generation
of
complexity,
originating
from
ability
couple
resulting
free
radicals
with
wide
range
partners.
First,
this
review
article
discusses
history
synthesis
organic
peroxides,
providing
context
necessary
understand
methodology.
Then,
it
highlights
91
examples
recent
applications
functionalization
bonds
accessed
through
metal-mediated
reduction
peroxides.
Finally,
we
provide
some
comments
about
safety
when
working
Organic Letters,
Год журнала:
2023,
Номер
25(6), С. 928 - 932
Опубликована: Фев. 2, 2023
A
facile
and
efficient
nickel-catalyzed
C-C
bond
cleavage/phosphorylation
of
various
cycloalkyl
hydroperoxides
was
developed.
This
radical
ring-opening
strategy
provided
practical
access
to
structurally
diverse
distal
ketophosphine
oxides
in
one
pot
through
concurrent
C═O/C-P
formation
with
high
atom
economy
under
mild
room
temperature
base-free
conditions.
Abstract
Transition‐metal‐catalyzed
radical
relay
cross‐coupling
reactions
of
1,3‐dienes
have
recently
emerged
as
one
the
most
powerful
methods
for
construction
structurally
diverse
allylic
compound
in
a
single
chemical
step.
However,
there
still
has
been
limited
success
expanding
substrate
scope
precursors
and
coupling
partners,
well
exploring
catalytic
asymmetric
variants.
Herein,
we
report
copper‐catalyzed
enantioselective
three‐component
1,2‐alkylesterification
using
cycloalkyl
hydroperoxides
carbonyl‐containing
alkyl
sources
carboxylic
acids
O‐nucleophiles
under
mild
redox‐neutral
conditions.
This
protocol
features
broad
good
functional
group
tolerance
with
respect
to
each
component,
providing
practical
access
variety
distally
keto‐functionalized
esters
high
enantioselectivity.
Mechanistic
studies
suggest
involvement
sequential
C−O
this
reaction.
Chemical Communications,
Год журнала:
2024,
Номер
60(40), С. 5334 - 5337
Опубликована: Янв. 1, 2024
A
photoredox-catalyzed
alkylarylation
of
activated
alkenes
via
a
ring-opening/Truce–Smiles
rearrangement
cascade
is
developed.
The
protocol
features
broad
substrate
scope
and
excellent
functional
group
compatibility.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2575 - 2582
Опубликована: Фев. 2, 2023
The
hitherto
difficult
site-selective
p-methoxybenzylation
of
secondary
amides
using
p-methoxybenzylated
alkylsilyl
peroxides
as
a
novel
agent
under
copper
catalysis
is
reported.
reaction
proceeds
mild
conditions
in
highly
chemoselective
manner.
This
approach
was
successfully
applied
to
the
peptides.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(14), С. 9927 - 9940
Опубликована: Июль 11, 2023
An
array
of
redox-neutral
alkylation/cyclization
cascade
reactions
N-functionalized
acrylamides
with
cycloalkyl
hydroperoxides
were
achieved
via
the
alkoxyl
radical-triggered
C-C
bond
cleavage.
Through
adjusting
radical
acceptors
on
N
atom,
a
variety
keto-alkylated
chain-containing
azaheterocycles,
including
indolo[2,1-a]isoquinolin-6(5H)-ones,
quinoline-2,4-diones,
and
pyrido[4,3,2-gh]phenanthridines
constructed
by
one-pot
procedure
good
yields
excellent
functional
group
tolerance.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4821 - 4826
Опубликована: Янв. 1, 2023
A
copper-catalyzed
C(sp
2
)–H
alkylsulfonylation
of
alkenes
using
alkylsilyl
peroxides
as
the
alkyl
radical
precursors
with
insertion
sulfur
dioxide
was
developed,
and
shown
to
provide
a
convenient
route
diverse
(
E
)-alkylsulfonyl
alkenes.
