Abstract
Functionalized
isoxazoles
provide
valuable
structural
motifs,
opening
up
a
wide
range
of
uses
in
the
medicinal,
pharmacological,
and
pharmaceutical
fields.
Within
this
scope,
an
efficient
approach
has
been
adopted
to
synthesize
novel
series
functionalized
isoxazole
derivatives,
starting
from
aza-aurone,
providing
reproducible
access
desired
excellent
yields.
All
synthesized
compounds
were
structurally
elucidated
through
use
various
spectroscopic
techniques
mass
spectrometry.
The
derivatives
generated
screened
for
their
antimicrobial
potential
against
fungus
Candida
albicans
as
well
three
bacterial
strains.
results
show
that
almost
all
tested
found
be
significantly
potent
C.
.
also
computed
using
Gaussian
software
package
with
6-31++G(d,p)
basis
set
at
B3LYP,
HF,
M062X
levels,
chemical
activities
compared.
Moreover,
molecular
docking
studies
performed
receptor.
suggest
newly
exhibit
scores
ranging
−10.29
−15.08
kcal/mol,
revealing
high
affinity
target
enzyme
(
5V5Z
).
Lastly,
drug
similarity
ADMET
(absorption,
distribution,
metabolism,
excretion,
toxicity)
properties
assessments
indicate
have
favorable
absorption,
metabolism
associated
proven
lack
toxicity.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
514, С. 215900 - 215900
Опубликована: Май 8, 2024
Catalysis
stands
as
a
cornerstone
in
chemical
synthesis,
pivotal
advancing
sustainable
manufacturing
pathways.
The
evolution
from
energy-intensive
to
catalytic
processes
has
marked
transformative
shift,
notably
exemplified
by
low-energy
methods.
These
processes,
operating
under
milder
conditions
and
emphasizing
selectivity
recyclability,
represent
the
forefront
of
chemistry.
This
review
navigates
through
an
array
reactions,
highlighting
their
diverse
applications
culminating
exploration
recent
strides
within
processes.
For
example,
explores
uses
such
enzyme
mimicking,
biodiesel
production,
carbon
dioxide
capture,
organic
synthesis.
Additionally,
it
covers
enzymatic
catalysis
photocatalysis
for
transformations,
energy
applications,
water
treatment.
Notably,
emphasizes
capabilities
single-atom
(SAC)
diatomic
catalysts
(DACs),
recognizing
exceptional
performance
catalyzing
reactions
at
minimal
activation
energies
while
maintaining
high
efficiency
mild
conditions.
By
elucidating
modulation
electronic
structure
offering
microelectronic
perspective,
aims
elucidate
mechanisms
underlying
activity
SAC
DACs.
Emphasizing
interplay
between
coordination
chemistry
principles
efficacy,
elucidates
indispensable
role
complexes
fortifying
sustainability
these
spotlighting
fusion
with
catalysis,
this
underscore
collective
influence
shaping
landscape
production.
RSC Advances,
Год журнала:
2024,
Номер
14(8), С. 5547 - 5565
Опубликована: Янв. 1, 2024
Spiro
heterocycle
frameworks
are
a
class
of
organic
compounds
that
possesses
unique
structural
features
making
them
highly
sought-after
targets
in
drug
discovery
due
to
their
diverse
biological
and
pharmacological
activities.
RSC Advances,
Год журнала:
2023,
Номер
13(47), С. 32858 - 32892
Опубликована: Янв. 1, 2023
This
review
highlights
recent
developments
in
the
microwave-assisted
organic
synthesis
of
N-
and
O-containing
heterocycles
with
specific
examples
pyrazolopyrimidines-,
coumarin-,
quinoline-,
isatin-based
scaffolds
their
associated
biological
activities.
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(2), С. 134 - 160
Опубликована: Янв. 1, 2024
Abstract:
Tetrazole
is
a
most
versatile
pharmacophore
of
which
more
than
twenty
FDAapproved
drugs
have
been
marketed
globally
for
the
management
various
diseases.
In
spite
many
remarkable
and
consistent
efforts
having
made
by
chemists
towards
development
greener
sustainable
strategies
synthesis
tetrazole
derivatives,
this
approach
still
needs
attention.
The
present
review
focuses
on
green
synthetic
preparation
derivatives
from
different
starting
materials
such
as
nitrile,
isonitrile,
carbonyl,
amine,
amide,
oxime
terminal
alkyne
functions.
mechanism
substrates
discussed.
addition
to
this,
four
component
Ugi-azide
reaction
also
described.
Of
note,
articles
exploited
several
water-mediated
solvent-free
methodologies
synthesis.
important
key
features
were
pinpointing
in
each
scheme
provides
excellent
guide
those
searching
selective
procedure
achieve
desired
transformation.
This
seeks
timely
account
(2011-2023)
splendid
array
ecofriendly
procedures
known
today
materials.
rational
enlighten
recent
advancements
substrates.
RSC Advances,
Год журнала:
2024,
Номер
14(42), С. 31072 - 31116
Опубликована: Янв. 1, 2024
This
article
describes
recent
advances
in
one-pot
chemoselective
reactions
and
their
mechanism
insights.
Here,
the
substrate,
catalyst,
solvent,
temperature
play
a
vital
role
modulating
chemoselectivity.
