Visible‐Light‐Irradiated Multicomponent Reactions of Aliphatic Amines, Propiolate Acid Esters, and CF3SO2Na for Accessing β‐CF3 Enamines
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(62)
Опубликована: Авг. 12, 2023
A
novel
one-pot
two-step
multicomponent
reaction
has
been
achieved
for
the
preparation
of
β-CF3
enamines
by
using
different
aliphatic
amines,
propiolates,
and
CF3
SO2
Na
as
starting
material.
In
this
protocol,
various
amines
including
primary
cyclic
or
acyclic
secondary
were
demonstrated
to
be
good
coupling
partners,
obtained
in
moderate
yields.
Among
them,
only
gave
pure
(E)-β-CF3
products.
The
synthetic
utility
MCRs
strategy
was
further
mild
conditions,
gram-scale
synthesis
natural
sunlight-induced
protocol.
Preliminary
mechanistic
studies
suggest
that
trifluoromethylation
C(sp2
)-H
involves
radical
process.
Язык: Английский
Visible Light‐Driven Metal‐ and Photocatalyst‐Free Synthesis of β‐Trifluoromethylated Enamines via Trifluoromethyl Thianthrenium Salts
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
A
novel
protocol
for
the
visible-light-driven
synthesis
of
β-trifluoromethylated
enamines
has
been
developed,
which
operates
without
use
transition
metals
or
any
photocatalysts,
utilizing
trifluoromethylthiosulfonium
salts
as
source
trifluoromethyl
groups
under
mild
conditions.
According
to
this
new
protocol,
more
than
40
products
have
prepared
in
moderate
good
yields.
In
addition
eliminating
need
expensive
toxic
and
methodology
proves
its
potential
scalability
through
air-stability,
safe
readily
available
reagents,
a
two-step
one-pot
procedure,
effective
gram-scale
reactions.
This
innovative
approach
not
only
demonstrates
promise
green
chemical
but
also
offers
pathway
advancement
fluorine
chemistry
sustainable
organic
synthesis.
Язык: Английский