Bimetallic Ru/Ru‐Catalyzed Asymmetric One‐Pot Sequential Hydrogenations for the Stereodivergent Synthesis of Chiral Lactones

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Март 21, 2024

Abstract Asymmetric sequential hydrogenations of α ‐methylene γ ‐ or δ ‐keto carboxylic acids are established in one‐pot using a bimetallic Ru/Ru catalyst system, achieving the stereodivergent synthesis all four stereoisomers both chiral and ‐lactones with two non‐vicinal carbon stereocenters high yields (up to 99%) excellent stereoselectivities >99% ee >20:1 dr). The compatibility Ru systems is investigated detail, it found that basicity reaction system plays key role hydrogenation processes. protocol can be performed on gram‐scale low loading 11000 S/C) resulting products allow for many transformations, particularly several intermediates useful preparation drugs natural products.

Язык: Английский

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Water-mediated one-pot multi-step synthesis of chiral 1,3-diarylpropan-1-ols by the asymmetric hydrofunctionalisation of simple alkynes

Green Chemistry, Год журнала: 2024, Номер 26(7), С. 4074 - 4078

Опубликована: Янв. 1, 2024

An enantioselective hydration–condensation-asymmetric transfer hydrogenation cascade process of simple alkynes and aldehydes in only water to prepare chiral 1,3-diarylpropan-1-ols has been developed.

Язык: Английский

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Diastereoselective Synthesis of Sulfoxide‐Functionalized N‐Heterocyclic Carbene Ruthenium Complexes: An Experimental and Computational Study

Chemistry - A European Journal, Год журнала: 2024, Номер 30(46)

Опубликована: Июнь 12, 2024

The synthesis of sulfoxide-functionalized NHC ligand precursors were carried out by direct and mild oxidation from corresponding thioether with high selectivity. Using these salts, a series cationic [Ru(II)(η

Язык: Английский

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Thiophene and benzo[b]thiophene

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 89 - 122

Опубликована: Янв. 1, 2024

Язык: Английский

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