Trifluoroacetic Acid Promotes Umpolung of 2‐Methylindole to Achieve C(sp3)‐H Activation

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract An umpolung strategy for the C( sp 3 )−H aminomethylation of 2‐methylindole has been developed using trifluoroacetic acid to induce transformation, with aminals serving as precursors iminium ion. Mechanistic studies have clearly shown that may play a pivotal role in this strategy. The utilization readily available starting materials, mild reaction conditions, tolerance complex functional groups, combine yields up 98% and potential biological applications render protocol applicable useful organic synthesis medicinal chemistry.

Язык: Английский

Five-membered ring systems: Pyrroles and benzo analogs

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173

Опубликована: Янв. 1, 2024

Язык: Английский

Catalytic Atroposelective Friedel-Crafts Alkylation to Access Axially Chiral C2-Arylindoles via Dynamic Kinetic Resolutions

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

An amine-catalyzed atroposelective FC alkylation of 2-arylindoles with α,β-unsaturated aldehydes via the DKR process has been developed. Various axially chiral were obtained in good yields high enantioselectivities.

Язык: Английский