Green Chemistry’s Contribution to the Kamal Qureshi Protocol: Comparing Various Activating Modes, the Use of Bentonitic Clay as the Catalyst, and the Use of a Green Solvent
Catalysts,
Год журнала:
2025,
Номер
15(3), С. 238 - 238
Опубликована: Март 1, 2025
After
attending
both
the
“Decade
to
Educate
in
Sustainable
Development
and
Agenda
30
of
UNESCO”
“ACS
GCI
Pharmaceutical
Roundtable”,
which
focused
on
sustainable
chemistry,
this
article,
a
green
chemistry
contribution
Kamal
Qureshi
protocol
is
offered;
thus,
DIM®
several
its
analogs
(3,3′-diindolylmethanes)
were
suitably
produced
under
protocol.
In
first
stage,
substrate
indol-3-yl
carbinol
was
evaluated
using
mechanochemistry
(the
best
mode)
comparison
other
activating
methods
(near-infrared
microwave
electromagnetic
irradiation
ultrasound),
wishing
highlight
employment
TAFF®,
an
excellent
well-characterized
natural
catalyst
(bentonitic
clay),
acetone,
solvent,
addition
analysis
procedures
real-time.
second
mechanochemical
methodology
extended
produce
set
fifteen
DIMs,
last
use
metric
exhibited
greenness
approach,
with
it
being
important
that,
our
knowledge,
after
search
literature,
time
that
process
has
been
demonstrate
greenness.
Язык: Английский
Enthalpy-Driven Interaction between Bovine Serum Albumin and Biomass-Derived Low-Melting Mixture Solvents (LoMMSs) for Efficient and Green Purification of Protein
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Green
separation
of
protein
(e.g.,
bovine
serum
albumin
(BSA))
by
low-melting
mixture
solvents
(LoMMSs)
depends
on
the
underlying
mechanism
between
BSA
and
LoMMSs.
Here,
we
for
first
time
find
that
eco-friendly
biomass-derived
LoMMSs
could
be
potentially
used
efficient
green
purification
enthalpy-driven
interactions.
Biomass-derived
possess
merits
high
biocompatibility,
degradability,
abundance,
low
cost.
A
single
high-affinity
binding
site
via
hydrogen
bonding
van
der
Waals
forces
is
observed
fluorescence
thermodynamic
analysis.
Experimental
results
from
circular
dichroism
infrared
spectra
demonstrate
addition
stabilizes
secondary
structure
protein.
This
work
provides
a
valuable
indication
design
cost-effective
Язык: Английский
Brønsted Acid Ionic-Liquid-Catalyzed Facile One-Pot Synthesis of 1-[(1,3-Benzothiazol-2-ylamino)methyl]-2-naphthols in a Green Medium
Synlett,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
A
rapid,
simple,
and
efficient
one-pot
protocol
has
been
developed
for
the
sustainable
synthesis
of
1-[(1,3-benzothiazol-2-ylamino)methyl]-2-naphthols
from
substituted
2-aminobenzothiazoles,
aryl
aldehydes,
2-naphthol
by
using
5
mol%
a
Bronsted
acid
ionic
liquid
as
catalyst.
This
method
offers
several
advantages
such
broad
substrate
scope,
short
reaction
time,
procedure,
benign
medium,
high
yield
low
catalyst
loading.
Moreover,
can
be
recycled
up
to
three
times
without
noteworthy
loss
in
catalytic
activity.
Язык: Английский
Mn(I)‐NNSe Pincer Complex Catalyzed Regioselective Synthesis of Bisindolylmethanes under Base and Solvent‐Free Conditions
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 23, 2025
Abstract
Here,
we
present
a
catalytic,
regioselective
synthesis
of
bisindolylmethanes
through
the
reaction
indoles
and
benzyl
alcohol
derivatives
mediated
by
metal‐ligand
cooperative
catalysis.
The
is
catalyzed
an
earth‐abundant
manganese‐NNSe
pincer
complex
without
need
for
base,
solvent,
additives,
or
hydrogen
acceptors
yielding
water
dihydrogen
as
environmentally
friendly
by‐products.
Notably,
C‐3
N
‐alkylation
indole,
commonly
observed
in
similar
reactions
were
not
detected.
Mechanistic
studies
suggest
that
catalysis
Mn(I)‐NNSe
initiates
conversion
to
benzaldehyde
elimination,
which
subsequently
facilitates
bisindolylmethane
derivatives.
To
highlight
practical
utility
this
method,
wide
range
substrates
can
be
activated
with
low
catalyst
loading
under
mild
conditions.
Язык: Английский
Synthesis of Dimeric Indoles from Friedel–Crafts Reaction of Indoles with Ketones Catalysed by a Bronsted Acid Ionic Liquid and Their Interactions with BSA and DNA
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(34), С. 14904 - 14923
Опубликована: Янв. 1, 2024
The
synthesis
of
35
dimeric
indole
derivatives
was
carried
out
by
using
[BCMIM][Cl]
ionic
liquid
as
a
catalyst.
binding
interaction
between
bovine
serum
albumin
(BSA)/deoxyribonucleic
acid
(DNA)
and
synthesized
compounds
has
been
investigated.
Язык: Английский
Transition Metal-free Efficient Synthesis of Bis(indolyl)propynes (BIPs)
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(34), С. 7039 - 7051
Опубликована: Янв. 1, 2024
A
transition
metal-free
approach
has
been
devised
for
the
synthesis
of
a
variety
bis(indolyl)propyne
(BIP)
derivatives.
The
strategy
involves
an
iodine-catalyzed
cascade
condensation
α,β-unsaturated
acetylenic
aldehydes
with
diversely
substituted
indoles.
was
applicable
to
gram
scale
and
library
50
molecules,
which
were
afforded
in
good
excellent
yields
(up
96%),
developed.
salient
features
reaction
involve
indole
based
privileged
scaffolds
short
time
under
conditions,
wide
substrate
scope
ambient
conditions.
Язык: Английский
Brønsted Acid Saponin Combined Catalyst (BASapC) for the Synthesis of Diverse 1,1‐Dihomoarylmethane Scaffolds in Aqueous Solution
ChemistrySelect,
Год журнала:
2024,
Номер
9(42)
Опубликована: Ноя. 1, 2024
Abstract
The
present
study
describes
the
synthesis
of
various
bioactive
compounds,
including
bis‐coumarins,
bis‐lawsones,
bis‐dimedones,
and
bis‐indolylmethanes,
using
a
novel
catalytic
system
called
“Brønsted
acid
saponin
combined
catalyst”
(BASapC).
BASapC
was
formed
by
combining
p
‐toluenesulfonic
(PTSA)
in
an
aqueous
medium.
prepared
proved
to
be
effective
facilitating
cascade‐type
Knoevenagel–Michael
addition
reactions
between
aromatic
aldehydes
with
4‐hydroxycoumarin,
lawsone,
dimedone,
or
indole
at
80
°C.
In
system,
PTSA
acted
as
powerful
Brønsted
acid,
activating
reactants,
whereas
served
natural
surfactant,
enhancing
solubility
organic
compounds
water.
This
approach
established
straightforwardness
robustness
diversity‐oriented
(DoS),
delivering
desired
products
good
excellent
yields.
Additionally,
exhibited
recyclability
for
least
four
cycles
without
significant
loss
activity.
Язык: Английский