Asian Journal of Chemistry,
Год журнала:
2022,
Номер
35(1), С. 135 - 142
Опубликована: Дек. 27, 2022
A
simple,
efficient,
economical
and
environmentally
benign
method
has
been
developed
for
one-pot
three
component
synthesis
of
isoxazolyl
amino
chromeno[4,3-b]pyridine
derivatives
from
4-amino-3-methyl-5-styrylisoxazoles,
malononitrile
(E)-3-benzylidenechroman-4-one
by
using
acetic
acid
(AcOH)
as
a
promoter
water
green
reaction
medium
under
thermal
condition.
The
interesting
features
this
are
environmental
friendly,
metal-free,
less
time,
wide
substrate
scope,
operational
simplicity,
easy
purification
products
good
yields.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(2), С. 244 - 251
Опубликована: Янв. 6, 2023
Abstract
Herein,
a
catalyst‐free
method
for
synthesizing
4,5‐dihydroisoxazole‐5‐methanols
is
proposed,
whereby
isoxazolines
are
constructed
through
the
NCS‐mediated
1,3‐dipolar
cycloaddition
reaction
of
aldoximes
and
allyl
alcohol
in
presence
K
2
CO
3
at
room
temperature
via
one‐pot
route.
The
was
achieved
water
medium
to
introduce
low‐cost
direct
protocol
isoxazolines.
This
offers
advantages
including
use
an
oxidant‐free
transition
metal‐free
approach,
broad
scope
aldoxime
substrates,
room‐temperature
reaction,
good
higher
yields
(42–92%),
involvement
gram‐scale
synthesis.
magnified
image
Synthetic Communications,
Год журнала:
2021,
Номер
unknown, С. 1 - 13
Опубликована: Фев. 1, 2021
A
simple,
efficient,
cost-effective
and
environmentally
friendly
synthesis
of
new
isoxazolyl
pyrido[2,3-d]pyrimidine
derivatives
11
has
been
developed
from
4-amino-3-methyl-5-styrylisoxazoles
7
by
using
polyethylene
glycol-400
(PEG-400)
as
a
solvent
well
catalyst.
Compound
on
treatment
with
methyl-2-chloronicotinate
8
in
the
presence
PEG-400
to
obtain
corresponding
(E)-methyl-2-((3-methyl-5-styrylisoxazol-4-yl)amino)nicotinates
9,
which
was
further
treated
different
arylisothiocyanates
10
under
heating
condition
afforded
target
products
pyrido[2,3-d]pyrimidines
good
excellent
yields.
The
compounds
11a-y
also
evaluated
for
their
antimicrobial
anti-inflammatory
activities.
Among
tested
compounds,
11w,
11x,
11y
showed
significant
activity
potent
that
standard
drugs.
superiority
this
method
is
catalyst
free,
operational
simplicity,
environmental
safety;
metal
broad
substrate
scope,
easy
purification,
high
yields
can
be
recovered
reused.
ChemSusChem,
Год журнала:
2021,
Номер
14(14), С. 2866 - 2871
Опубликована: Май 31, 2021
Abstract
A
catalyst‐free
direct
aerobic
oxidative
annulation
reaction
of
2‐aminobenzylic
amines
and
α
‐
hydroxy
ketones
efficiently
afforded
versatile
5
H
‐1,4‐benzodiazepine
derivatives
by
employing
air
as
economic
green
oxidant
under
mild
conditions.
Interestingly,
solvent
was
found
to
be
crucial
the
reaction,
so
that
using
acetic
acid
best
an
efficient
practical
method
could
achieved,
requiring
no
catalysts
or
additives
at
all.
This
tolerates
a
wide
range
scaled
up
multigram
synthesis
directly
applied
in
one‐step
pharmaceutically
active
N‐
desmethylmedazepam
derivatives,
revealing
potential
this
new
skeleton‐based
pharmaceuticals
chemicals.
Synthetic Communications,
Год журнала:
2020,
Номер
51(2), С. 279 - 289
Опубликована: Окт. 5, 2020
A
simple,
efficient,
cost-effective
and
one-pot
eco-friendly
protocol
has
been
developed
for
the
synthesis
of
new
isoxazolyl-4-hydroxyindole-3-carboxylate
derivatives
by
using
4-amino-3-methyl-5-styrylisoxazoles,
2,3-diketoesters
1,3-cyclohexanediones,
in
presence
p-toluenesulfonic
acid
(p-TSA)
catalyst
aqueous
medium.
The
advantages
this
are
inexpensive
catalyst,
metal-free,
shorter
reaction
time,
environmentally
friendly,
high
yields,
water
as
a
solvent,
wide
substrates
scope
easy
purification.
