Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 57 - 77
Опубликована: Янв. 1, 2023
Язык: Английский
Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(11)
Опубликована: Авг. 24, 2023
Abstract The aziridination of chalcones with iminoiodinanes under photoredox conditions has been reported. reaction proceeds through nitrene radical anion intermediate generated from iminoiodinanes. trapping anions by afforded trans ‐aziridine products exclusively. scope the in terms both substrates is considerably wide and most cases ‐3‐aryl‐aziridine‐2‐ketones were isolated good yields. challenging due to electron‐deficient nature substrate, making this only second example (after trifluoromethyl alkenes) photocatalytic double bonds.
Язык: Английский
Процитировано
5
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(21), С. 4462 - 4469
Опубликована: Июль 23, 2024
Abstract A class of cyclohexenone(aryl)iodonium salts was readily prepared from 2‐iodocyclohexenones and arenes under mild conditions. This novel series hypervalent iodonium building blocks exhibits dual characteristics hyperiodonium α,β‐unsaturated cyclic ketones, enabling access to intricate aza‐heterocycles. The reaction these with arylamines or aryl sulfonamides affords 2‐acylaziridines, while 2‐aminobenzimidazoles 2‐aminoimidazoles leads the formation 1 H ‐imidazo[1,2‐ a ]imidazole‐fused compounds. transformation is postulated proceed through an exclusive hyperiodonium‐mediated N ‐Michael addition followed by ‐annulation cascade.
Язык: Английский
Процитировано
1
Tetrahedron Letters, Год журнала: 2022, Номер 112, С. 154208 - 154208
Опубликована: Окт. 26, 2022
Язык: Английский
Процитировано
6
ChemistrySelect, Год журнала: 2022, Номер 7(22)
Опубликована: Июнь 9, 2022
Abstract Aziridines are an important class of synthetic intermediates that widely used in the synthesis useful compounds and found pharmaceuticals, natural products, other functional materials. Several with aziridine ring system exhibit significant biological activity as well. Consequently, aziridines has been focus intense research over last two decades. Despite numerous successful methods, no review article exclusively on Enone aziridination published to date. Therefore, up‐to‐date developments from enones, which convenient precursors, by nucleophilic addition reactions described advantages, limitations, mechanistic pathways.
Язык: Английский
Процитировано
5
European Journal of Organic Chemistry, Год журнала: 2022, Номер 2022(28)
Опубликована: Июнь 21, 2022
Abstract A novel electrochemical synthesis of azaborininones was developed using 2‐aminobenzamides and boronic acids under mild conditions. The advantage this reaction system is that it avoided metal catalysts high‐temperature. Various 1,3,2‐benzodiazaborininones were obtained in moderate to excellent yields.
Язык: Английский
Процитировано
4
Angewandte Chemie, Год журнала: 2023, Номер 135(21)
Опубликована: Март 16, 2023
Abstract Cyclopropanes are desirable structural motifs with valuable applications in drug discovery and beyond. Established alkene cyclopropanation methods give rise to cyclopropanes a limited array of substituents, difficult scale, or both. Herein, we disclose new cyclopropane synthesis through the formal coupling abundant carbon pronucleophiles unactivated alkenes. This strategy exploits dicationic adducts derived from electrolysis thianthrene presence substrates. We find that these dielectrophiles undergo methylene via alkenyl thianthrenium intermediates. protocol is scalable, proceeds high diastereoselectivity, tolerates diverse functional groups on both pronucleophile partners. To validate utility this procedure, prepared an substituted analogs established en route multiple pharmaceuticals.
Язык: Английский
Процитировано
2
Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 57 - 77
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
0