P(NMe2)3-Mediated Regioselective N-Alkylation of 2-Pyridones via Direct Deoxygenation of α-Keto Esters
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 3657 - 3665
Опубликована: Фев. 17, 2024
A
practical
and
regioselective
direct
N-alkylation
of
2-pyridones
is
enabled
by
use
α-keto
esters
in
the
P(NMe2)3-mediated
deoxygenation
process.
The
reaction
proceeds
under
mild
conditions
to
produce
N-alkylated
with
high
selectivity
generality,
protocol
shown
be
applicable
for
scale-up
synthesis,
which
makes
it
promising
applications.
Язык: Английский
Advances in the Synthetic Utility of Difluorocarbene Generated from TMSCF3 (Ruppert‐Prakash Reagent) and Its Derivatives
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
Organofluorine
compounds
are
of
pivotal
significance
particularly,
in
drug
and
agrochemical
industries
different
strategies
have
been
designed
for
their
synthesis.
The
last
two
decades
witnessed
the
emergence
difluorocarbene
as
an
efficient
synthetic
tool,
providing
easy
access
to
organofluorine
compounds.
This
review
summarises
reactions
generated
from
Ruppert‐Prakash
reagent
(TMSCF
3
)
its
derivatives
TMSCF
2
Cl
Br.
Among
various
fluorination
techniques
available,
chemistry
offers
a
cost
effective
procedure,
opening
avenue
large
number
details
developments
utility
derivatives,
till
date.
Язык: Английский
Efficient Synthesis of O-Aryl Esters Using a Recyclable MWCNTs-MNPs/Met-NiCl2 Nanocatalyst in Ionic Liquid
Journal of Inorganic and Organometallic Polymers and Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
Язык: Английский
2‐Hydroxypyridines as N‐ and O‐Nucleophiles in Organic Synthesis
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
27(2)
Опубликована: Ноя. 6, 2023
Abstract
2‐Hydroxypyridines
have
emerged
as
versatile
nucleophiles
in
organic
synthesis.
The
N
‐
and
O
‐functionalization
of
2‐hydroxypyridines
affords
straightforward
practical
methods
for
the
construction
‐substituted
2‐pyridones
2‐hydroxypyridines,
which
are
important
structural
motifs
numerous
natural
products,
pharmaceuticals
biologically
active
compounds.
Nonetheless,
competition
between
presents
an
inevitable
formidable
challenge.
In
past
few
decades,
chemoselective
and/or
has
received
extensive
attention
from
synthetic
community,
resulting
development
elegant
effective
strategies
to
address
this
chemoselectivity.
This
review
provides
a
summary
recent
advancements
realm
transition‐metal
organo‐catalyzed,
well
visible‐light
promoted
functionalization
including
‐alkylation,
‐allylation,
‐arylation,
‐alkenylation,
‐alkenylation.
Язык: Английский
Gold(I)-catalyzed synthesis of N-alkenyl 2-pyridonyl sec-amines
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(27), С. 5646 - 5652
Опубликована: Янв. 1, 2024
One-pot
gold(
i
)-catalyzed
synthesis
was
developed
in
order
to
prepare
N
-alkenyl
2-pyridonyl
amines.
This
method
provides
a
series
of
amines
moderate
excellent
yields
(up
98%).
Язык: Английский
Multigram-Scale Synthesis of a gem-Difluoro-Substituted 4,5,6,7-Tetrahydrobenzo[c]thiophen-4-one Heterocycle via Oxidative Chlorination and Radical Smiles Rearrangement
Synlett,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 14, 2023
Abstract
We
report
an
optimized
synthetic
route
towards
a
functionalized
4,5,6,7-tetrahydrobenzo[c]thiophene
heterocycle
bearing
gem-difluoromethylene
moiety
in
4
steps
with
overall
yield
of
43%.
The
CF2
fragment
was
incorporated
using
building
block
approach,
by
coupling
appropriate
fluorinated
alcohol
C-3
sulfonyl
chloride,
synthesized
via
oxidative
chlorination
exocyclic
benzyl
thioether.
Visible-light-mediated
Smiles
rearrangement
the
resulting
fluorosulfonate
ester
then
furnishes
desired
thiophene
scaffold.
Язык: Английский