Multi-hydroxyl POSS supported iridium complexes as a recyclable catalyst for selective synthesis of N-/C-substituted indoles and the total synthesis of HIV-1 fusion inhibitor

Journal of Catalysis, Год журнала: 2023, Номер 429, С. 115205 - 115205

Опубликована: Ноя. 24, 2023

Язык: Английский

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Synthesis and Spectral Studies of Iron‐Catalyzed Multicomponent Synthesis of 4‑Phosphorylated 4H‑Chromenes from 2‐Hydroxybenzyl Alcohols

ChemistrySelect, Год журнала: 2025, Номер 10(5)

Опубликована: Янв. 30, 2025

Abstract A facile, mild, effective, and multicomponent protocol for the production of 4‑phosphorylated‐4H‑chromenes through an aldol condensation, Michael addition, cyclization was established. The C─C, C─P, C─O bonds were constructed during reaction to produce desired product from 2‐hydroxybenzyl alcohols. synthesized compounds characterized by standard techniques. important features this are operational simplicity, moderate conditions, use a low‐cost iron complex, high atom economy.

Язык: Английский

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Shining a light on Fe-catalyzed borrowing hydrogen alkylation

Trends in Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Green chemistry approach to the synthesis of 2-aryl/heteroaryl substituted 2,3-dihydroquinazolin-4(1H)-ones using lemon juice under concentrated solar radiations as a renewable source

RSC Advances, Год журнала: 2024, Номер 14(44), С. 32350 - 32357

Опубликована: Янв. 1, 2024

This study explores a novel and eco-friendly synthesis of 22 derivatives 2-aryl/heteroaryl substituted 2,3-dihydroquinazolin-4(1 H )-ones using concentrated solar radiation (CSR) lemon juice as natural catalyst.

Язык: Английский

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Iron-catalyzed intramolecular reductive cyclization of o-nitroarenes to indoles under visible light irradiation

Tetrahedron Letters, Год журнала: 2023, Номер 123, С. 154543 - 154543

Опубликована: Май 16, 2023

Язык: Английский

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One-pot sequential synthesis of unsymmetrical diarylmethanes by using methylene chloride as a C1-synthon

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Bisindolylmethane (BIM) and its derivatives are widely used in the pharmaceutical industry due to their significant biological activities. However, most reported synthetic methods focused on synthesis of symmetric BIMs, while unsymmetrical BIMs remains a challenge. Herein, an unprecedented two-step one-pot method afford unsymmetrically substituted 3,3'-BIM frameworks, using methylene chloride (DCM) as C1-synthon is reported. In this protocol, formation two C-C bonds can be achieved

Язык: Английский

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Visible Light Mediated Iron‐Catalyzed One‐Pot Synthesis of Chromenopyrroles from Benzyl Alcohols, 2‐Hydroxyacetophenones and Methyl/Ethyl Isocyanoacetate at Room Temperature

ChemistrySelect, Год журнала: 2024, Номер 9(37)

Опубликована: Сен. 30, 2024

Abstract An effective, facile, trivial, and one‐pot procedure for the synthesis of chromenopyrroles from benzyl alcohols, 2‐hydroxyacetophenones, methyl/ethyl isocyanoacetate at room temperature in presence visible light has been developed. The Ag salt plays an important role activation cyclization step. Air‐stable low‐cost Knölker iron complex utilized dehydrogenation primary alcohols that would typically require a higher temperature. established protocol is scalable extensive functional group tolerance, generating good to excellent yields

Язык: Английский

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Six-membered ring systems: With O and/or S atoms

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 421 - 484

Опубликована: Янв. 1, 2024

Язык: Английский

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Multi-Hydroxyl POSS Supported Iridium Complexes as a Recyclable Catalyst for Selective Synthesis of N-/C-Substituted Indoles and the Total Synthesis of HIV-1 Fusion Inhibitor

Опубликована: Янв. 1, 2023

A novel pyridyl-thiadiazole ligand has been designed, synthesized, and employed in the preparation of a heterogeneous iridium catalyst supported on multi-hydroxyl polyhedral oligomeric silsesquioxane. The as-prepared exhibits excellent catalytic activity one-pot cascade selective synthesis N-/C-substituted indole derivatives from amino alcohols via borrowing hydrogen strategy. Meanwhile, it was observed that this approach good functional group tolerance broad substrate scope. Notably, by employing system, an inhibitor against gp41-mediated HIV-1 fusion core structure could be conveniently synthesized 2-aminophenethyl alcohol benzyl 40.6% total yield for only four steps “borrowing hydrogen” Mechanistic explorations showed transformation undergoes processes, involving N/C-alkylation through strategy, oxidative cyclization. Recycling experiments disclosed easily recovered reused at least seven times with TON.

Язык: Английский

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Iodine catalyzed one-pot three-step synthesis of isoxazoles from primary alcohols and 3-O-propargyl flavones using DMSO as the oxidant

Tetrahedron Letters, Год журнала: 2023, Номер 131, С. 154799 - 154799

Опубликована: Окт. 15, 2023

Язык: Английский

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