Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups
Marine Drugs,
Год журнала:
2023,
Номер
21(12), С. 606 - 606
Опубликована: Ноя. 24, 2023
A
total
of
16
novel
carboxymethyl
chitosan
derivatives
bearing
quinoline
groups
in
four
classes
were
prepared
by
different
synthetic
methods.
Their
chemical
structures
confirmed
Fourier-transform
infrared
spectroscopy
(FTIR),
nuclear
magnetic
resonance
(NMR),
and
elemental
analysis.
The
antioxidant
experiment
results
vitro
(including
DPPH
radical
scavenging
ability,
superoxide
anion
hydroxyl
ferric
reducing
power)
demonstrated
that
adding
to
(CS)
(CMCS)
enhanced
the
ability
CS
CMCS.
Among
them,
both
N,
O-CMCS
N-TM-O-CMCS
showed
over
70%.
In
addition,
their
radicals
reached
more
than
90%
at
maximum
tested
concentration
1.6
mg/mL.
Moreover,
cytotoxicity
assay
was
carried
out
on
L929
cells
MTT
method,
indicated
all
no
(cell
viability
>
75%)
except
derivative
1a,
which
low
1000
μg/mL
50.77
±
4.67%).
conclusion,
remarkable
weak
cytotoxicity,
highlighting
potential
use
food
medical
applications.
Язык: Английский
A Comprehensive Investigation of Diverse Synthetic Methodologies for Constructing Quinoline Frameworks: A Critical Overview
ChemistrySelect,
Год журнала:
2025,
Номер
10(10)
Опубликована: Март 1, 2025
Abstract
Recently,
quinoline
has
emerged
as
a
critical
heterocyclic
structure,
attracting
attention
for
its
diverse
industrial
and
synthetic
organic
chemistry
applications.
This
compound
is
essential
developing
novel
lead
compounds
in
drug
discovery
extensively
studied
therapeutic
derivatives
medicinal
chemistry.
An
extensive
body
of
literature
details
the
methodologies
synthesizing
this
key
scaffold
functionalization
to
enhance
biological
efficacy.
Numerous
synthesis
protocols
have
been
documented,
highlighting
significance
ongoing
chemical
research.
These
include
various
strategies,
such
transition
metal‐catalyzed
reactions
environmentally
sustainable
processes,
which
are
crucial
constructing
functionalizing
derivatives.
review
aims
systematically
examine
procedures
findings,
addressing
limitations
these
pathways
their
environmental
impacts.
Additionally,
curated
selection
quinolines
will
be
presented.
Язык: Английский