Fe(II)-Catalyzed Metal-Ligand Cooperative Approach for Selective C3-Alkylation of Indoles DOI

Sutanuva Mandal,

Nanda D. Paul, Subhajit Chakraborty

и другие.

Synlett, Год журнала: 2024, Номер 35(20), С. 2508 - 2514

Опубликована: Авг. 12, 2024

Abstract Herein, we report a straightforward approach for synthesizing C3-alkylated indoles selectively via an iron-catalyzed alkylation of using alcohols as the alkylating agents. A well-defined, air-stable, and easy-to-prepare Fe(II) catalyst redox-active tridentate arylazo scaffold was used catalyst. Various were prepared in moderate to good isolated yields by coupling with different substituted alcohols. The methodology is compatible gram-scale synthesis. Control experiments performed unveil mechanism, which revealed that reaction proceeds borrowing-hydrogen pathway where coordinated azo-aromatic ligand actively participates during catalysis, acting electron hydrogen reservoir.

Язык: Английский

Fe(II)-Catalyzed Metal-Ligand Cooperative Approach for Selective C3-Alkylation of Indoles DOI

Sutanuva Mandal,

Nanda D. Paul, Subhajit Chakraborty

и другие.

Synlett, Год журнала: 2024, Номер 35(20), С. 2508 - 2514

Опубликована: Авг. 12, 2024

Abstract Herein, we report a straightforward approach for synthesizing C3-alkylated indoles selectively via an iron-catalyzed alkylation of using alcohols as the alkylating agents. A well-defined, air-stable, and easy-to-prepare Fe(II) catalyst redox-active tridentate arylazo scaffold was used catalyst. Various were prepared in moderate to good isolated yields by coupling with different substituted alcohols. The methodology is compatible gram-scale synthesis. Control experiments performed unveil mechanism, which revealed that reaction proceeds borrowing-hydrogen pathway where coordinated azo-aromatic ligand actively participates during catalysis, acting electron hydrogen reservoir.

Язык: Английский

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