Therapies, Год журнала: 2022, Номер 78(4), С. 456 - 456
Опубликована: Дек. 10, 2022
Язык: Английский
Journal of the Endocrine Society, Год журнала: 2024, Номер 8(3)
Опубликована: Янв. 10, 2024
Abstract Context In some patients, symptoms may persist after COVID-19, defined as long COVID. Its pathogenesis is still debated and many hypotheses have been raised. Objective Our primary objective was to evaluate the corticotroph somatotroph functions of patients previously infected with SARS-CoV-2 experiencing post–COVID-19 syndrome detect any deficiencies that explain Methods A cross-sectional study conducted including who had contracted a postinfection period 3 months or less 15 months, divided into 2 groups. The first group (G1) comprised fully recovered while second (G2) included outcome comparison functions. Results total 64 were groups, each consisting 32 patients. G2 exhibited more frequently anterior pituitary deficits compared G1 (P = .045): for axis (G1: 6.3% vs G2: 28.1%) 31.3% 59.4%). Baseline cortisol level significantly lower in 13.37 µg/dL 11.59 µg/dL) .045). peak also 23.60 19.14 .01). For axis, insulin growth factor-1 146.03 ng/mL 132.25 ng/mL) .369). hormone 4.82 2.89 .041). Conclusion results showed COVID our cohort likely deficiencies. endocrine hypothesis involving insufficiency can be considered
Язык: Английский
Процитировано
15
Pituitary, Год журнала: 2024, Номер unknown
Опубликована: Май 18, 2024
Abstract Purpose This systematic review aims to examine the latest research findings and assess impact of COVID-19 vaccination on pituitary gland. Method PubMed Tripdatabase were searched from January 1st, 2020 February 12th, 2024. Case reports, case series reviews related post disease included. Eligible articles tabulated analysed in attempt provide an overview epidemiology, clinical presentation, imaging, treatment, outcomes pathophysiological background disease. Results Among 23 reports included this review, hypophysitis was reported 9 patients, apoplexy (PA) 6 cases, SIADH 5 cases Isolated ACTH deficiency 2 cases. Additionally, precipitating adrenal crisis registered 7 patients tumor enlargement 1 patient after receiving vaccination. Conclusion Despite rarity these events, our suggest association between subsequent development diseases. The most common manifestations include with ADH deficiency, PA SIADH, symptoms typically emerging shortly vaccine administration. Potential pathogenetic mechanisms molecular mimicry, adjuvants vaccine-induced thrombotic thrombocytopenia (VITT), presence ACE2 receptors hypothalamus-pituitary system contributing process. These can aid diagnostic treatment decisions for presenting syndromes. Nevertheless, given safety efficacy currently available vaccines remain robust we strongly advocate continuing pursuing efforts.
Язык: Английский
Процитировано
8
Vaccines, Год журнала: 2022, Номер 10(12), С. 2004 - 2004
Опубликована: Ноя. 24, 2022
Since the emergence of COVID-19 pandemic at end 2019, a massive vaccination campaign has been undertaken rapidly and worldwide. Like other vaccines, vaccine is not devoid side effects. Typically, adverse effects include transient headache, fever, myalgia. Endocrine organs are also affected by The major SARS-CoV-2 vaccine-associated endocrinopathies reported since beginning thyroid pancreas disorders. vaccine-induced pituitary diseases have become more frequently described in literature. We searched PubMed/MEDLINE for commentaries, case reports, series articles reporting disorders following vaccination. search was reiterated until September 2022, which eight reports were found. In all cases, there no personal or familial history disease described. All patients had previous infection prior to episode. Regarding type vaccines administered, 50% received (BNT162b2; Pfizer–BioNTech) (ChAdOx1 nCov-19; AstraZeneca). five disorder developed after first dose corresponding vaccine. types disorder, hypophysitis (variable clinical aspects ranging from lesion stalk thickness) three apoplexy. time period between ranged one seven days. Depending on each case’s follow-up time, complete remission obtained apoplexy cases but only with (persistence central diabetes insipidus). Both quantity quality published data about inconveniences limited. Pituitary disorders, unlike occur very quickly (less than days versus two months disease). This partially explained ease reaching pituitary, small gland. Therefore, this gland overspread, explains speed onset symptoms (especially ADH deficiency rapid deficit evocative symptoms). Accordingly, these pilot findings offer clinicians future direction be vigilant possible will allow them accurately orient medical assistance when they present remarkable symptoms, such as asthenia, polyuro-polydipsia, severe
Язык: Английский
Процитировано
28
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Янв. 25, 2023
GENERAL COMMENTARY article Front. Endocrinol., 25 January 2023Sec. Neuroendocrine Science Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1111581
Язык: Английский
Процитировано
14
BMC Endocrine Disorders, Год журнала: 2023, Номер 23(1)
Опубликована: Фев. 22, 2023
Abstract Background The development of an effective vaccine is a powerful tool to contain the global spread coronavirus disease 2019 (COVID-19). Still, it raises potential safety concerns about subsequent enhancement associated immunopathology. Increasing evidence shows that endocrine system, including hypophysis, may be involved in COVID-19. Moreover, occasional but increasing reports disorders involving thyroid have been reported after severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine. Among them, few cases encompass pituitary. Here we report rare case central diabetes insipidus following SARS-CoV-2 vaccination. Case presentation We 59-year-old female patient with 25-year history Crohn's long-term remission, who presented sudden onset polyuria eight weeks administration mRNA Laboratory evaluation was consistent isolated insipidus. Magnetic resonance imaging displayed involvement infundibulum and posterior hypophysis. Eighteen months vaccination, she still under desmopressin treatment had stable pituitary stalk thickening on magnetic imaging. Although disease-associated hypophysitis has reported, scarce. In absence other recognizable causes hypophysitis, believe hypophysis our triggered by Conclusions potentially Further studies are needed understand better mechanisms underlying autoimmune endocrinopathies context COVID-19 infection
Язык: Английский
Процитировано
12
Journal of Personalized Medicine, Год журнала: 2023, Номер 13(8), С. 1210 - 1210
Опубликована: Июль 30, 2023
Hypophysitis, a rare inflammatory disorder of the pituitary gland, has seen an uptick in reported cases recent years. Our objective is to summarize most research on etiopathogenesis, molecular mechanisms, and genetics both primary secondary hypophysitis. Primary autoimmune hypophysitis (PAH): During acute phase disease, gland enlarged due infiltration T B lymphocytes. The chronic characterized by progressive irreversible atrophy. APA may play role management, diagnosis, prognosis PAH. Specific autoantibodies such as anti-GH, anti-PIT-1, anti-T-PIT have been found patients with hypopituitarism. A study suggested that mechanism escaping clonal deletion mounting immune response against self antigens can explain unusual nature observed PAH patients. cytokine array shows presence gamma-interferon interleukin-17. Patients carrying mutations PIT1 or PROP1 genes present Individuals HLA DQ8 haplotype are four times more likely develop Immune checkpoint inhibitors induce (IIHs): IIHs increasingly frequent toxicity treatment targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) programmed cell death-1 (PD-1). ICIs inhibit CTLA-4 pathway, leading overactivation binding PD-1/PD-L1 suppresses activity cells, promotes conversion T-helpers into T-regulatory activates pro-survival signaling pathways cancer cells. Cytokines crucial IIHs. B-cell IIHs, suggesting antibody-mediated injury contribute. Genetic polymorphisms PD-1 increase risk alleles also be involved onset IIHs; this association presents possible alternative mechanistic hypothesis. linked paraneoplastic syndrome triggered ectopic expression specific antigens. SARS-CoV-2-related hypophysitis: Recently, literature occurrences associated SARS-CoV-2 virus; long COVID-19 infundibulo-neuro-hypophysitis. virus enters central nervous system because its distinct interaction angiotensin-converting enzyme receptors via spike proteins capillary endothelium, it directly damages effect occur indirectly through inflammation release cytokines. exact remains ambiguous. available data endocrine complications vaccine scant. Nonetheless, isolated documented. Treatment Glucocorticoids cornerstone managing hypophysitis, given their targeted action inflammation. better understanding etiopathogenesis lead effective personalized strategies.
Язык: Английский
Процитировано
9
Endocrine Journal, Год журнала: 2024, Номер 71(8), С. 799 - 807
Опубликована: Янв. 1, 2024
COVID-19 vaccines have resulted in a remarkable reduction both the morbidity and mortality associated with COVID-19. However, there are reports of endocrine rare clinical conditions linked to vaccination. In this report, we present case hypophysitis following vaccination review literature on condition. This involved 72-year-old male type 1 diabetes who experienced symptoms such as vomiting, appetite loss, headaches his fifth vaccine dose. He was diagnosed secondary adrenal insufficiency; subsequent assessment revealed an enlarged pituitary gland. Unlike previous cases, our patient has partial recovery from insufficiency, function gradually improved over time. Anti-pituitary antibodies (APAs) against corticotrophs, thyrotrophs, gonadotrophs, folliculo stellate cells (FSCs) were detected serum samples taken 3 months after onset. Hypophysitis is condition, only eight cases reported by end 2023, most occurring initial or second Symptoms similar those classic dysfunction. Pituitary insufficiency persistent, five above patients presenting posterior dysfunction three anterior Two had autoimmune diseases. Our suggests potential link between acquired immunity, APA production, damage. To elucidate etiology vaccination, detailed investigation nonspecific necessary.
Язык: Английский
Процитировано
3
BMC Endocrine Disorders, Год журнала: 2024, Номер 24(1)
Опубликована: Май 20, 2024
Although vaccination against coronavirus disease (COVID-19) has several side effects, hypopituitarism due to hypophysitis rarely been reported.
Язык: Английский
Процитировано
2
Pituitary, Год журнала: 2024, Номер 27(6), С. 874 - 888
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
2
Опубликована: Март 6, 2024
Abstract: The emergence of the COVID-19 pandemic has led to rapid and worldwide devel-opment investigation multiple vaccines. While most side effects these vaccines are mild transient, potentially severe adverse events may occur involve endocrine system. This narrative review aims explore current knowledge on potential following vaccination, with thyroid disorders being common. Data about pi-tuitary, adrenal, diabetes, gonadal will also be reviewed. provides a comprehensive understanding pathogenesis associated SARS-CoV-2 A PubMed/MEDLINE, Embase database (Elsevier), Google Scholar research were performed. Case reports case series, original studies, reviews written in English published online up 31 August 2023 selected is accumulating. However, their causal relationship not strong enough make definite conclusion, further studies needed clarify mechanisms linked vac-cines.
Язык: Английский
Процитировано
1