Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(7)
Опубликована: Янв. 17, 2023
Abstract
Since
the
insight
to
fuse
Fenton
chemistry
and
nanomedicine
into
cancer
therapy,
great
signs
of
progress
have
been
made
in
field
chemodynamic
therapy
(CDT).
However,
exact
mechanism
CDT
is
obscured
by
unique
tumor
chemical
environment
inevitable
nanoparticle‐cell
interactions,
thus
impeding
further
development.
In
this
Scientific
Perspective,
significance
clarified,
complex
deconstructed
primitive
biological
research
directions
based
on
kinetics
signaling
pathways
are
discussed
detail.
Moreover,
beneficial
outlooks
presented
enlighten
evolution
next‐generation
CDT.
Hopefully,
Perspective
can
inspire
new
ideas
advances
for
provide
a
reference
breaking
down
interdisciplinary
barriers
nanomedicine.
Annual Review of Biochemistry,
Год журнала:
2017,
Номер
86(1), С. 193 - 224
Опубликована: Май 1, 2017
Autophagy
and
the
ubiquitin-proteasome
system
are
two
major
quality
control
pathways
responsible
for
cellular
homeostasis.
As
such,
they
provide
protection
against
age-associated
changes
a
plethora
of
human
diseases.
Ubiquitination
is
utilized
as
degradation
signal
by
both
systems,
albeit
in
different
ways,
to
mark
cargoes
proteasomal
lysosomal
degradation.
Both
systems
intersect
communicate
at
multiple
points
coordinate
their
actions
proteostasis
organelle
This
review
summarizes
molecular
details
how
proteasome
autophagy
functionally
interconnected
cells
indicates
common
principles
nodes
communication
that
can
be
therapeutically
exploited.
Annual Review of Medicine,
Год журнала:
2016,
Номер
67(1), С. 293 - 307
Опубликована: Янв. 14, 2016
Acute
kidney
injury
(AKI)
is
a
global
public
health
concern
associated
with
high
morbidity,
mortality,
and
healthcare
costs.
Other
than
dialysis,
no
therapeutic
interventions
reliably
improve
survival,
limit
injury,
or
speed
recovery.
Despite
recognized
shortcomings
of
in
vivo
animal
models,
the
underlying
pathophysiology
AKI
its
consequence,
chronic
disease
(CKD),
rich
biological
targets.
We
review
recent
findings
relating
to
renal
vasculature
cellular
stress
responses,
primarily
intersection
unfolded
protein
response,
mitochondrial
dysfunction,
autophagy,
innate
immune
response.
Maladaptive
repair
mechanisms
that
persist
following
acute
phase
promote
inflammation
fibrosis
phase.
Here
macrophages,
growth-arrested
tubular
epithelial
cells,
endothelium,
surrounding
pericytes
are
key
players
progression
disease.
Better
understanding
these
complex
interacting
pathophysiological
mechanisms,
their
relative
importance
humans,
utility
biomarkers
will
lead
strategies
prevent
treat
impede
CKD
end-stage
(ESRD).
Biomedicine & Pharmacotherapy,
Год журнала:
2019,
Номер
118, С. 109249 - 109249
Опубликована: Июль 24, 2019
The
endoplasmic
reticulum
(ER)
acts
as
a
moving
organelle
with
many
important
cellular
functions.
As
the
ER
lacks
sufficient
nutrients
under
pathological
conditions
leading
to
uncontrolled
protein
synthesis,
aggregation
of
unfolded/misfolded
proteins
in
lumen
causes
unfolded
response
(UPR)
be
activated.
Chronic
stress
produces
endogenous
or
exogenous
damage
cells
and
activates
UPR,
which
leads
impaired
intracellular
calcium
redox
homeostasis.
UPR
is
capable
recognizing
accumulation
ER.
enhances
ability
fold
apoptosis
when
function
fails
return
normal.
In
different
malignancies,
can
effectively
induce
occurrence
autophagy
because
malignant
tumor
need
re-use
their
organelles
maintain
growth.
Autophagy
simultaneously
counteracts
stress-induced
expansion
has
effect
enhancing
cell
viability
non-apoptotic
death.
Oxidative
also
affects
mitochondrial
through
overload.
Mitochondrial
reactive
oxygen
species
(ROS)
are
produced
by
calcium-enhanced
release.
toxic
substances
mitochondria
destroys
basic
function.
It
known
that
sustained
trigger
an
inflammatory
pathway.
Inflammatory
thought
associated
development.
This
review
discusses
emerging
links
between
responses
autophagy,
oxidative
stress,
signals
well
potential
development
targeting
this
multifaceted
signaling
pathway
various
cancers.
