Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Год журнала: 2018, Номер 25(3), С. 486 - 541

Опубликована: Янв. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Язык: Английский

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Nature, Год журнала: 2017, Номер 547(7661), С. 99 - 103

Опубликована: Апрель 28, 2017

Язык: Английский

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Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Март 29, 2021

Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based

Язык: Английский

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The gasdermins, a protein family executing cell death and inflammation

Nature reviews. Immunology, Год журнала: 2019, Номер 20(3), С. 143 - 157

Опубликована: Ноя. 5, 2019

Язык: Английский

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Lysosomes as dynamic regulators of cell and organismal homeostasis

Nature Reviews Molecular Cell Biology, Год журнала: 2019, Номер 21(2), С. 101 - 118

Опубликована: Ноя. 25, 2019

Язык: Английский

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Science, Год журнала: 2020, Номер 368(6494)

Опубликована: Апрель 16, 2020

Cytotoxic lymphocyte-mediated immunity relies on granzymes. Granzymes are thought to kill target cells by inducing apoptosis, although the underlying mechanisms not fully understood. Here, we report that natural killer and cytotoxic T lymphocytes gasdermin B (GSDMB)-positive through pyroptosis, a form of proinflammatory cell death executed family pore-forming proteins. Killing results from cleavage GSDMB lymphocyte-derived granzyme A (GZMA), which unleashes its activity. Interferon-γ (IFN-γ) up-regulates expression promotes pyroptosis. is highly expressed in certain tissues, particularly digestive tract epithelia, including derived tumors. Introducing GZMA-cleavable into mouse cancer tumor clearance mice. This study establishes gasdermin-mediated pyroptosis as lymphocyte-killing mechanism, may enhance antitumor immunity.

Язык: Английский

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Caspases in Cell Death, Inflammation, and Disease

Immunity, Год журнала: 2019, Номер 50(6), С. 1352 - 1364

Опубликована: Июнь 1, 2019

Язык: Английский

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NLRP3 inflammasome activation and cell death

Cellular and Molecular Immunology, Год журнала: 2021, Номер 18(9), С. 2114 - 2127

Опубликована: Июль 28, 2021

Язык: Английский

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Neuronal Cell Death

Physiological Reviews, Год журнала: 2018, Номер 98(2), С. 813 - 880

Опубликована: Фев. 28, 2018

Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity adult neurons to proliferate or be replaced. The concept used simple as there were just two three types, so we had work out which type was involved in our particular pathology then block it. However, now know that are at least a dozen ways for die, blocking mechanism may not prevent from dying, non-neuronal cells also contribute neuronal death. We review here mechanisms by intrinsic extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, mitochondrial permeability transition. next explore development, those induced axotomy, aberrant cell-cycle reentry, glutamate (excitoxicity oxytosis), loss connected neurons, aggregated proteins unfolded protein response, oxidants, inflammation, microglia. reassess forms occur stroke Alzheimer’s disease, most pathologies involving discuss why has been difficult pinpoint involved, if matters, molecular overlap interplay between subroutines, therapeutic implications these multiple overlapping

Язык: Английский

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Pyroptosis: A new frontier in cancer

Biomedicine & Pharmacotherapy, Год журнала: 2019, Номер 121, С. 109595 - 109595

Опубликована: Ноя. 8, 2019

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage gasdermin D (GSDMD) and activation inactive cytokines like IL-18 IL-1β. has been reported be closely associated some diseases atherosclerosis diabetic nephropathy. Recently, studies found that pyroptosis can influence proliferation, invasion metastasis tumor, which regulated non-coding RNAs other molecules. Hence, we provided overview morphological molecular characteristics pyroptosis. We also focus on mechanism regulating in tumor cells as well potential roles cancer explore diagnostic markers cancers contributing prevention treatment cancers.

Язык: Английский

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