Pharmacological Research,
Год журнала:
2024,
Номер
202, С. 107119 - 107119
Опубликована: Фев. 28, 2024
Intervertebral
disc
(IVD)
degeneration
is
a
frequent
cause
of
low
back
pain
and
the
most
common
disability.
Treatments
for
symptomatic
IVD
degeneration,
including
conservative
treatments
such
as
analgesics,
physical
therapy,
anti-inflammatories
surgeries,
are
aimed
at
alleviating
neurological
symptoms.
However,
there
no
effective
to
prevent
or
delay
degeneration.
Previous
studies
have
identified
risk
factors
aging,
inflammation,
genetic
factors,
mechanical
overload,
nutrient
deprivation
smoking,
but
metabolic
dysfunction
has
not
been
highlighted.
IVDs
largest
avascular
structures
in
human
body
determine
hypoxic
glycolytic
features
nucleus
pulposus
(NP)
cells.
Accumulating
evidence
demonstrated
that
intracellular
associated
with
comprehensive
review
lacking.
Here,
by
reviewing
physiological
IVDs,
pathological
processes
changes
functions
genes
we
highlight
pathway
intact
mitochondrial
function
essential
homeostasis.
In
degenerated
NPs,
glycolysis
downregulated.
Boosting
HIF1α
overexpression
protects
against
Moreover,
correlations
between
diseases
diabetes,
obesity
their
underlying
molecular
mechanisms
discussed.
Hyperglycemia
diabetic
leads
cell
senescence,
senescence-associated
phenotype
(SASP),
apoptosis
catabolism
extracellualr
matrix
IVDs.
Correcting
global
disorders
insulin
GLP-1
receptor
agonist
administration
beneficial
diabetes
Overall,
summarized
recent
progress
investigations
on
contributions
provide
new
perspective
correcting
may
be
treating
Aging and Disease,
Год журнала:
2023,
Номер
14(3), С. 794 - 794
Опубликована: Янв. 1, 2023
Sirtuins
(SIRT1-SIRT7),
a
family
of
nicotinamide
adenine
dinucleotide
(NAD+)-dependent
enzymes,
are
key
regulators
life
span
and
metabolism.
In
addition
to
acting
as
deacetylates,
some
sirtuins
have
the
properties
deacylase,
decrotonylase,
adenosine
diphosphate
(ADP)-ribosyltransferase,
lipoamidase,
desuccinylase,
demalonylase,
deglutarylase,
demyristolyase.
Mitochondrial
dysfunction
occurs
early
on
acts
causally
in
pathogenesis
neurodegenerative
diseases,
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD).
implicated
regulation
mitochondrial
quality
control,
which
is
highly
associated
with
diseases.
There
growing
evidence
indicating
that
promising
well-documented
molecular
targets
for
treatment
disorders
by
regulating
biogenesis,
mitophagy,
fission/fusion
dynamics,
unfolded
protein
responses
(mtUPR).
Therefore,
elucidation
etiology
sirtuin-mediated
control
points
new
prospects
However,
mechanisms
underlying
remain
obscure.
this
review,
we
update
summarize
current
understanding
structure,
function,
an
emphasis
cumulative
putative
effects
biology
particularly
their
roles
control.
addition,
outline
potential
therapeutic
applications
diseases
targeting
through
exercise
training,
calorie
restriction,
sirtuin
modulators
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(8), С. 2882 - 2882
Опубликована: Апрель 14, 2023
Mitochondria
are
semiautonomous
doubly
membraned
intracellular
components
of
cells.
The
organelle
comprises
an
external
membrane,
followed
by
coiled
structures
within
the
membrane
called
cristae,
which
further
surrounded
matrix
spaces
space
between
and
internal
organelle.
A
typical
eukaryotic
cell
contains
thousands
mitochondria
it,
make
up
25%
cytoplasm
present
in
cell.
acts
as
a
common
point
for
metabolism
glucose,
lipids,
glutamine.
chiefly
regulate
oxidative
phosphorylation-mediated
aerobic
respiration
TCA
cycle
generate
energy
form
ATP
to
fulfil
cellular
needs.
possesses
unique
supercoiled
stranded
mitochondrial
DNA
(mtDNA)
encodes
several
proteins,
including
rRNA
tRNA
crucial
transport
electrons,
phosphorylation,
initiating
genetic
repair
processors.
Defects
act
principal
factor
chronic
diseases.
dysfunction
can
cause
malfunction
leakage
electron
respiratory
chain,
leading
increase
reactive
oxygen
species
signaling
aberrant
oncogenic
tumor
suppressor
alter
pathways
involved
metabolism,
disrupt
redox
balance,
induce
endurance
towards
apoptosis
treatments
play
major
role
developing
metabolic
conditions.
current
review
presents
knowledge
on
aspects
its
cancer,
diabetes
mellitus,
infections,
obesity.
Pharmacological Research,
Год журнала:
2024,
Номер
202, С. 107119 - 107119
Опубликована: Фев. 28, 2024
Intervertebral
disc
(IVD)
degeneration
is
a
frequent
cause
of
low
back
pain
and
the
most
common
disability.
Treatments
for
symptomatic
IVD
degeneration,
including
conservative
treatments
such
as
analgesics,
physical
therapy,
anti-inflammatories
surgeries,
are
aimed
at
alleviating
neurological
symptoms.
However,
there
no
effective
to
prevent
or
delay
degeneration.
Previous
studies
have
identified
risk
factors
aging,
inflammation,
genetic
factors,
mechanical
overload,
nutrient
deprivation
smoking,
but
metabolic
dysfunction
has
not
been
highlighted.
IVDs
largest
avascular
structures
in
human
body
determine
hypoxic
glycolytic
features
nucleus
pulposus
(NP)
cells.
Accumulating
evidence
demonstrated
that
intracellular
associated
with
comprehensive
review
lacking.
Here,
by
reviewing
physiological
IVDs,
pathological
processes
changes
functions
genes
we
highlight
pathway
intact
mitochondrial
function
essential
homeostasis.
In
degenerated
NPs,
glycolysis
downregulated.
Boosting
HIF1α
overexpression
protects
against
Moreover,
correlations
between
diseases
diabetes,
obesity
their
underlying
molecular
mechanisms
discussed.
Hyperglycemia
diabetic
leads
cell
senescence,
senescence-associated
phenotype
(SASP),
apoptosis
catabolism
extracellualr
matrix
IVDs.
Correcting
global
disorders
insulin
GLP-1
receptor
agonist
administration
beneficial
diabetes
Overall,
summarized
recent
progress
investigations
on
contributions
provide
new
perspective
correcting
may
be
treating
