The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders DOI
Xin Liu, Wei Wang,

Qunhua Nie

и другие.

Neuroscience Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Язык: Английский

The cell biology of ferroptosis DOI
Scott J. Dixon, James A. Olzmann

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(6), С. 424 - 442

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

333
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond DOI Creative Commons
Chao Mao, Min Wang, Li Zhuang

и другие.

Protein & Cell, Год журнала: 2024, Номер 15(9), С. 642 - 660

Опубликована: Фев. 29, 2024

Abstract Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell as unique forms regulated resulting from an imbalance in the cellular metabolism. This review discusses mechanisms death—ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis—and explores their potential cancer therapy. Our underscores complexity pathways offers insights into innovative therapeutic avenues for treatment.

Язык: Английский

Процитировано

47
Design of CoQ10 crops based on evolutionary history DOI Creative Commons

Jing-Jing Xu,

Lei Yuan,

Xiaofan Zhang

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

4
Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: A review DOI

Leihan Wang,

Zhenni ChenLiu,

Daorong Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140523 - 140523

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

3
Rhodoquinone carries electrons in the mammalian electron transport chain DOI Creative Commons

Jonathan Valeros,

M Jérôme, Tenzin Tseyang

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Highlights•RQ is present in mitochondria isolated from certain mouse and human tissues•RQ carries electrons to fumarate as the electron acceptor, independently of O2 levels•The ETC can be reprogrammed RQ/fumarate pathway using genetic pharmacologic tools•Reprogramming mitigates hypoxia-induced damage vitro vivoSummaryUbiquinone (UQ), only known carrier mammalian transport chain (ETC), preferentially delivers terminal acceptor oxygen (O2). In hypoxia, ubiquinol (UQH2) diverts these onto instead. Here, we identify rhodoquinone (RQ), an detected purified tissues that through reversal succinate dehydrogenase, independent environmental levels. The strictly vivo undetectable cultured cells. Using tools reprogram UQ/O2 pathway, establish distinct ETCs support unique programs mitochondrial function RQ confers protection upon hypoxia exposure vivo. Thus, discovering presence mammals, unveil a tractable therapeutic strategy exploits flexibility ameliorate hypoxia-related conditions.Graphical abstract

Язык: Английский

Процитировано

3
Mitochondrial proteome research: the road ahead DOI
Zakery N. Baker, Patrick Forny, David J. Pagliarini

и другие.

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 25(1), С. 65 - 82

Опубликована: Сен. 29, 2023

Язык: Английский

Процитировано

28
COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells DOI Creative Commons
Ludovic Pélosi, Laura Morbiato,

Arthur Burgardt

и другие.

Molecular Cell, Год журнала: 2024, Номер 84(5), С. 981 - 989.e7

Опубликована: Янв. 30, 2024

Язык: Английский

Процитировано

15
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers DOI Creative Commons
Chao Mao, Guang Lei, Amber D. Horbath

и другие.

Molecular Cell, Год журнала: 2024, Номер 84(10), С. 1964 - 1979.e6

Опубликована: Май 1, 2024

Язык: Английский

Процитировано

14
The redox requirement and regulation during cell proliferation DOI
Z P. Zhen, Jiankun Ren, Jiajun Zhu

и другие.

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер 35(5), С. 385 - 399

Опубликована: Янв. 22, 2024

Язык: Английский

Процитировано

12
HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers DOI Open Access

Tatiana A. Stetskaya,

Ksenia Kobzeva, Sergey M. Zaytsev

и другие.

RESEARCH RESULTS IN BIOMEDICINE, Год журнала: 2024, Номер 10(2), С. 175 - 186

Опубликована: Июнь 28, 2024

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. Since the influence vascular stressors prompts cross-reactivity with microbial human HSPD1 (HSP60), which results in degradation endothelium intimal infiltration by mononuclear cells, HSP60 viewed as key player autoimmune theory atherosclerosis. The aim study: present pilot study investigated whether tag SNP rs11682567 associated risk IS. Materials methods: DNA samples from 1176 unrelated Russian subjects (708 IS patients 468 healthy controls) were genotyped for tagging gene using MassArray-4 system. A log-additive regression model was used to interpret associations between genotypes risk. Results: We discovered that smoking, major environmental endothelial stressor, dramatically modifies link IS, relationship only being seen smokers (risk allele G; OR = 2.11, 95% CI 1.17-3.82; P 0.0075). functional annotation this revealed G impacts expression alternative splicing genes regulate brain ischemia-reperfusion injury, reactive oxygen species production, toll-like receptor 4 internalization, pro-inflammatory properties. Moreover, creates binding sites transcription factors jointly involved biological processes encompass neurogenesis, monocyte differentiation, fatty acid metabolism, cell signalling, apoptosis. Conclusion: Thus, represents novel genetic marker ischemic stroke, whose significance pathogenesis mediated smoking.

Язык: Английский

Процитировано

12