Uncovering the Mechanisms: The Role of Biotrophic Fungi in Activating or Suppressing Plant Defense Responses DOI Creative Commons
Michel Leiva-Mora, Yanelis Capdesuñer, Ariel Villalobos-Olivera

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 635 - 635

Опубликована: Сен. 5, 2024

This paper discusses the mechanisms by which fungi manipulate plant physiology and suppress defense responses producing effectors that can target various host proteins. Effector-triggered immunity effector-triggered susceptibility are pivotal elements in complex molecular dialogue underlying plant-pathogen interactions. Pathogen-produced effector molecules possess ability to mimic pathogen-associated patterns or hinder binding of pattern recognition receptors. Effectors directly nucleotide-binding domain, leucine-rich repeat receptors, downstream signaling components defense. Interactions between these receptor-like kinases plants critical this process. Biotrophic adeptly exploit networks key hormones, including salicylic acid, jasmonic abscisic ethylene, establish a compatible interaction with their hosts. Overall, highlights importance understanding interplay fungal develop effective strategies for disease management.

Язык: Английский

The NLR family of innate immune and cell death sensors DOI Creative Commons
Balamurugan Sundaram, Rebecca E. Tweedell, Sivakumar Prasanth Kumar

и другие.

Immunity, Год журнала: 2024, Номер 57(4), С. 674 - 699

Опубликована: Апрель 1, 2024

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition that detect wide variety pathogenic and sterile triggers. Activation specific NLRs initiates pro- or anti-inflammatory signaling cascades the formation inflammasomes—multi-protein complexes induce caspase-1 activation to drive inflammatory cytokine maturation lytic cell death, pyroptosis. Certain inflammasomes act integral components larger death complexes—PANoptosomes—driving another form PANoptosis. Here, we review current understanding evolution, structure, function in health disease. We discuss concept NLR networks their roles driving immunity. An improved mechanistic may provide therapeutic strategies applicable across infectious diseases cancer.

Язык: Английский

Процитировано

61
Small holes, big impact: Stomata in plant–pathogen–climate epic trifecta DOI Creative Commons
Shuguo Hou, Olivier Rodrigues, Zunyong Liu

и другие.

Molecular Plant, Год журнала: 2023, Номер 17(1), С. 26 - 49

Опубликована: Дек. 1, 2023

Язык: Английский

Процитировано

30
Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome DOI Creative Commons
Muniyandi Selvaraj, AmirAli Toghani, Hsuan Pai

и другие.

PLoS Biology, Год журнала: 2024, Номер 22(10), С. e3002868 - e3002868

Опубликована: Окт. 18, 2024

Nucleotide-binding domain and leucine-rich repeat (NLR) proteins can engage in complex interactions to detect pathogens execute a robust immune response via downstream helper NLRs. However, the biochemical mechanisms of NLR activation by upstream sensor NLRs remain poorly understood. Here, we show that coiled-coil NRC2 from Nicotiana benthamiana accumulates vivo as homodimer converts into higher-order oligomer upon its virus disease resistance protein Rx. The cryo-EM structure NbNRC2 resting state revealed intermolecular mediate formation contribute receptor autoinhibition. These dimerization interfaces have diverged between paralogous NRC insulate critical network nodes enable redundant pathways, possibly minimise undesired cross-activation evade pathogen suppression immunity. Our results expand molecular pointing transition homodimers oligomeric resistosomes.

Язык: Английский

Процитировано

11
From molecule to cell: the expanding frontiers of plant immunity DOI
Lei Li, J. Liu, Jian‐Min Zhou

и другие.

Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2024, Номер 51(7), С. 680 - 690

Опубликована: Фев. 26, 2024

Язык: Английский

Процитировано

5
Lighting-up wars: Stories of Ca2+ signaling in plant immunity DOI Creative Commons

Zilu Zhang,

Qi Wang, Haiqiao Yan

и другие.

New Crops, Год журнала: 2024, Номер 1, С. 100027 - 100027

Опубликована: Май 18, 2024

Calcium ions (Ca2+) serve as key messengers in plant immune reactions. A typical Ca2+ signaling involves three steps: encoding specific signatures by Ca2+-permeable channels, decoding signals sensors, and downstream responses. This review focuses on plasma membrane-localized channels cytosolic unraveling their roles influx during pattern-triggered immunity, effector-triggered autoimmunity. Several unresolved questions were highlighted, including the regulation of channel activity for induction mechanism behind influx-triggered hypersensitive response cell death. concise overview provides insights into complex interplay paving way future investigations molecular plant-microbe interactions.

Язык: Английский

Процитировано

5
The role of quercetin in NLRP3-associated inflammation DOI

Jiaqi Wu,

Tongtong Lv, Yü Liu

и другие.

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 22, 2024

Язык: Английский

Процитировано

5
Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice DOI
Yufei Tang, Shuqi Feng, Keyi Yao

и другие.

Biomaterials, Год журнала: 2025, Номер 317, С. 123083 - 123083

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0
Assessment of Self-Activation and Inhibition of Wheat Coiled-Coil Domain Containing NLR Immune Receptor Yr10CG DOI Creative Commons
Nan Wu,

Wanqing Jiang,

Zhaoxia Xiang

и другие.

Plants, Год журнала: 2025, Номер 14(2), С. 278 - 278

Опубликована: Янв. 19, 2025

Plant immunity is largely governed by nucleotide-binding leucine-rich repeat receptor (NLR). Here, we examine the molecular activation and inhibition mechanisms of wheat CC-type NLR Yr10CG, a previously proposed candidate for Yr10 resistance gene. Though recent studies have identified YrNAM as true gene, Yr10CG remains an important in understanding NLR-mediated wheat. In this study, found that overexpression either full-length or its CC domain Nicotiana benthamiana did not trigger cell death, suggesting robust autoinhibitory mechanism within Yr10CG. However, observed mutations conserved MHD motif, specifically D502G, activated induced death. Structural modeling indicated mutation disrupted key interactions promoting local flexibility activation. We further explored effector recognition potential creating chimeric proteins with Sr50 domains, revealing both NB-ARC LRR domains are necessary recognition, while likely functions downstream immune signaling. Additionally, disrupting membrane localization through L11E abolished self-activation, requirement association Our findings contribute to CC-NLR autoinhibition mechanisms, highlighting engineering crop improvement.

Язык: Английский

Процитировано

0
The wheat NLR pair RXL/Pm5e confers resistance to powdery mildew DOI Creative Commons
Guanghao Guo, Kaihong Bai,

Yikun Hou

и другие.

Plant Biotechnology Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Summary Powdery mildew poses a significant threat to global wheat production and most cloned deployed resistance genes for breeding encode nucleotide‐binding leucine‐rich repeat (NLR) immune receptors. Although two genetically linked NLRs function together as an NLR pair have been reported in other species, this phenomenon has relatively less studied wheat. Here, we demonstrate that tightly genes, RXL Pm5e , arranged head‐to‐head orientation, mediate powdery The of the / is validated by mutagenesis, gene silencing, gene‐editing assays. Interestingly, both atypical NLRs, with possessing truncated NB‐ARC (nucleotide binding adaptor shared APAF‐1, plant R proteins CED‐4) domain featuring coiled‐coil (CC) domain. Notably, lack integrated associated effector recognition found all previously pairs. Additionally, exhibit preference forming hetero‐complexes rather than homo‐complexes, highlighting their cooperative role disease resistance. We further show CC specifically suppresses hypersensitive response induced through competitive interaction, revealing regulatory mechanisms within pair. Our study sheds light on molecular mechanism underlying Pm5e‐ mediated provides new example

Язык: Английский

Процитировано

0
Atypical RXLR effectors are involved in Phytophthora cactorum pathogenesis DOI Creative Commons

Zeyang Zheng,

Juanjuan Liu,

Wenzhong You

и другие.

aBIOTECH, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

RXLR effectors are pathogenic factors secreted from oomycetes to manipulate the immunity of host. Typical contain an RXLR-dEER motif at N-terminus, whereas atypical RXLRs show variations on this motif. The oomycete Phytophthora cactorum is known infect over 200 plant species, resulting in significant agricultural economic losses. Although genome-wide identification and functional analyses typical P. have been performed, little PcaRXLRs. Here, we identified RXLRs, both atypical, compared them with those other pathogens. Fewer were possibly due fewer duplication events RXLRs. In contrast, percentage was higher than suggesting roles pathogenesis. Analysis gene expression showed that most transcribed, their functionality. Transient two Nicotiana benthamiana they induced necrosis dependent host SGT1 HSP90. Furthermore, additional suppressed defense response N. promoted infection. These results demonstrate vital role provide valuable information evolutionary patterns interactions plants. online version contains supplementary material available 10.1007/s42994-025-00198-4.

Язык: Английский

Процитировано

0