Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(15), С. 6824 - 6863

Опубликована: Янв. 1, 2022

This review comprehensively presents the cutting-edge advances of enzyme confinement using different porous organic frameworks.

Язык: Английский

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Metal-organic frameworks with different dimensionalities: An ideal host platform for enzyme@MOF composites

Coordination Chemistry Reviews, Год журнала: 2021, Номер 454, С. 214327 - 214327

Опубликована: Дек. 3, 2021

Язык: Английский

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Rational Design of Photocatalysts for Controlled Polymerization: Effect of Structures on Photocatalytic Activities

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 5476 - 5518

Опубликована: Янв. 4, 2022

Over the past decade, use of photocatalysts (PCs) in controlled polymerization has brought new opportunities sophisticated macromolecular synthesis. However, selection PCs these systems been typically based on laborious trial-and-error strategies. To tackle this limitation, computer-guided rational design knowledge structure-property-performance relationships emerged. These strategies provide rapid and economic methodologies for tuning performance functionality a system, thus providing further polymer science. This review provides an overview employed photocontrolled summarizes their progression from early to current state-of-the-art. Background theories electronic transitions are also introduced establish perspective quantum chemistry. Typical examples each type structure-property then presented enlighten future polymerization.

Язык: Английский

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Where Chemocatalysis Meets Biocatalysis: In Water

Chemical Reviews, Год журнала: 2022, Номер 123(9), С. 5262 - 5296

Опубликована: Дек. 6, 2022

Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major challenge, solution to which, however, is associated with numerous advantages, run such one-pot processes water: majority enzyme-catalyzed take place water as Nature's medium, thus enabling broad synthetic diversity when due option use virtually all types enzymes. Furthermore, cheap, abundantly available, environmentally friendly, making it, principle, an ideal medium. On other hand, most routinely performed today organic solvents (which might deactivate enzymes), appearing make it difficult combine biocatalysis toward cascades water. Several creative approaches solutions that enable combinations chemo- be realized applied problems are presented herein, reflecting state-of-the-art this blossoming field. Coverage has been sectioned into three parts, after introductory remarks: (1) Chapter 2 focuses on historical developments initiated area research; (2) 3 describes key post-initial discoveries have advanced field; (3) 4 highlights latest achievements provide attractive main question compatibility between (used predominantly aqueous media) (that remains solvents), Chapters covering mainly literature from ca. 2018 present. 5 6 brief overview where field stands, challenges lie ahead, ultimately, prognosis looking future chemoenzymatic catalysis synthesis.

Язык: Английский

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Enhancing Enzyme Activity by the Modulation of Covalent Interactions in the Confined Channels of Covalent Organic Frameworks

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(21)

Опубликована: Март 10, 2022

Controllable regulations on the enzyme conformation to optimize catalytic performance are highly desired for immobilized biocatalysts yet remain challenging. Covalent organic frameworks (COFs) possess confined channels with finely tunable pore environment, offering a promising platform encapsulation. Herein, we covalently cytochrome c (Cyt c) in size-matched of COFs different contents anchoring site, and significant enhancement stability activity (≈600 % relative compared free enzyme) can be realized by optimizing covalent interactions. Structural analyses Cyt suggest that bonding could induce conformational perturbation resulting more accessible active sites. The effectiveness interaction modulation together tailorable offers promise develop high-performance biocatalysts.

Язык: Английский

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Modification strategies for visible-light photocatalysts and their performance-enhancing effects on photocatalytic degradation of volatile organic compounds

Renewable and Sustainable Energy Reviews, Год журнала: 2023, Номер 189, С. 113948 - 113948

Опубликована: Окт. 29, 2023

Язык: Английский

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Bioinspired Coassembly of Copper Ions and Nicotinamide Adenine Dinucleotides for Single-Site Nanozyme with Dual Catalytic Functions

Analytical Chemistry, Год журнала: 2023, Номер 95(5), С. 2865 - 2873

Опубликована: Янв. 24, 2023

Nanozymes can imitate the catalytic properties of natural enzymes while overcoming limitations such as high cost, poor robustness, and difficulty in recycling. However, rational design facile preparation nanozymes are still demand. Inspired by chemical structure laccase, we report an amorphous metal-organic coordination nanocomposite named CuNAD, which is composed copper ions nicotinamide adenine dinucleotide (NAD+) via a simple coordinating coassembly process. As single-site nanozyme, CuNAD exhibits excellent robustness under extreme conditions, significantly stronger activity for phenolic compounds, 4.02-fold higher sensitivity epinephrine detection than laccase. Furthermore, breaking through functional constraints also able to activate H2O2 at neutral pH, benefiting one-step chromogenic platform cholesterol. This approach demonstrates potential develop biomimicking may boost more insights into structure-function relationship nanozymes.

Язык: Английский

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Biotransformation of lignin into 4-vinylphenol derivatives toward lignin valorization

Green Chemistry, Год журнала: 2024, Номер 26(4), С. 1770 - 1789

Опубликована: Янв. 1, 2024

Biological valorization of lignin toward various high-value products can effectively reduce the dependence on petroleum-based resources and contribute to building a renewable carbon cycle system.

Язык: Английский

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Biocatalytic oxidation of fatty alcohols into aldehydes for the flavors and fragrances industry

Biotechnology Advances, Год журнала: 2021, Номер 56, С. 107787 - 107787

Опубликована: Июнь 18, 2021

Язык: Английский

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A review on the immobilization of pepsin: A Lys-poor enzyme that is unstable at alkaline pH values

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 210, С. 682 - 702

Опубликована: Май 1, 2022

Pepsin is a protease used in many different applications, and instances, it utilized an immobilized form to prevent contamination of the reaction product. This enzyme has two peculiarities that make its immobilization complex. The first one related poor presence primary amino groups on surface (just Lys terminal group). second stability at alkaline pH values. Both features this be considered complicated goal, as most protocols utilize for immobilization. review presents some attempts get pepsin biocatalyst their applications. high density anionic (Asp Glu) anion exchange simpler, but makes strategies immobilize (e.g., amino-glutaraldehyde supports) more mixed ion exchange/hydrophobic adsorption than real covalent Finally, we propose possibilities can permit not only enzyme, also stabilization via multipoint attachment.

Язык: Английский

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