Опубликована: Янв. 1, 2024
Язык: Английский
Advanced Science, Год журнала: 2025, Номер 12(20)
Опубликована: Май 1, 2025
Abstract Chimeric antigen receptor T (CAR‐T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological malignancies and more recently expanded into applications for solid tumors autoimmune diseases. Emerging multidimensional profiling technologies offer promising solutions enhancing CAR‐T efficacy, overcoming resistance, facilitating the development novel constructs. The integration genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics enables comprehensive understanding intrinsic mechanisms underlying therapy, while single‐cell spatial omics significantly improve data resolution analytical depth. Coupled with advances biomedical engineering, visualization form foundation generation by bridging microscopic macroscopic scales enabling dynamic, 3D vivo monitoring behavior. Artificial intelligence (AI) further supports this framework analysis complex, high‐dimensional datasets. This review highlights recent within therapy explores cutting‐edge developments AI applications. full convergence multi‐omics, tools, is poised to deliver transformative insights governing therapy.
Язык: Английский
Процитировано
2
Tissue Engineering and Regenerative Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
0
Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100529 - 100529
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Abstract As an emerging technology for modeling cancer tissue in vitro, 3D bioprinting facilitates precise spatial manipulation of cells and biomaterials, allowing the replication complex architectures accurate recapitulation tumor microenvironment (TME) features. This review initially elucidates mechanisms underlying tumorigenesis associated TME complexity, with a particular focus on roles stromal cell populations characteristics extracellular matrix (ECM) progression. Moreover, this work summarizes recent advances bioprinted models, emphasizing their application studying cell‐ECM interactions, stromal‐tumor crosstalk, vasculature formation investigating occurrence metastasis, as well utility high‐throughput drug screening therapeutic development. Finally, discusses advantages challenges creating biomimetic while providing insights into future development trajectories potential translational applications research personalized medicine. By focusing these critical dimensions, aims to highlight transformative role advancing vitro models ultimate goal improving treatment, prevention, patient outcomes.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101823 - 101823
Опубликована: Май 1, 2025
The heterogeneity and complex extracellular matrix (ECM) characteristics of non-small cell lung cancer (NSCLC) present significant challenges for understanding its pathological mechanisms advancing precise treatment strategies. This study characterized the physicochemical properties native NSCLC ECM to inform biomimetic design 3D models utilizing biomaterials light-based bioprinting technologies. A tunable model was constructed that replicates interfacial structures stiffness both tissue adjacent normal tissue. elucidates impact on cellular behaviors, including proliferation, invasion, drug sensitivity, delineates role CCN1 gene under different mechanical conditions. Specifically, it demonstrates a reduction in expression within soft matrices can attenuate migratory proliferative capabilities tumor cells. Furthermore, primary patient-derived bioprinted tissues validated fidelity clinical samples predictive potential responses combined chemotherapy immunotherapy. establishes versatile platform modeling research, biomaterial strategies replicate microenvironment optimize therapeutic approaches.
Язык: Английский
Процитировано
0
Trends in biotechnology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0