Dimeric PD-L1 specific affibody grafted Fe-based nanosheets for tumor-targeting dual-mode magnet resonance imaging and enhancement of Photothermal-Immunotherapy

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159400 - 159400

Опубликована: Янв. 9, 2025

Язык: Английский

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Folic-acid-functionalized Fe₃O₄@C@Pt nanozyme for synergistic catalytic-photothermal tumor therapy

New Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The study presents a Fe 3 O 4 @C@Pt nanozyme, modified with folic acid, that efficiently targets tumor cells and inhibits growth through combined photothermal therapy catalysis.

Язык: Английский

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Targeted Theranostic Nanoprobes Assisted In Vivo NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Alveolar echinococcosis (AE) is a serious parasitic infectious disease that highly invasive and destructive to the liver has high mortality rate. However, currently, there no effective targeted imaging treatment method for precise detection therapy of AE. We proposed new two-step targeting strategy (TSTS) AE based on poly(lactic-co-glycolic acid) (PLGA). designed constructed novel type ICG@PLGA@Lips nanoprobe with integrated properties. First, we used characteristics PLGA gluconeogenic raw material target during blood circulation. Then, utilized specifically penetrating shell achieve specific identification in liver. Under 808 nm laser excitation, effectively achieved accurate near-infrared II (NIR-II, 900-1700 nm) fluorescence methods through PDT effects. improved optical properties ICG, while liposomes further biocompatibility nanoprobe. As showed strong NIR-II emission good biocompatibility, advantages navigation surgical resection lesions. Thus, assistance ICG@PLGA@Lips, real-time first time. successfully obtained vivo imaging-guided photodynamic/surgical This TSTS-based exploration provided early AE, which expected significantly improve prognosis patients.

Язык: Английский

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Exploring structures-properties and interactions of acrylic-hydrogel adsorbents with metal ions and organics using nuclear magnetic resonance and Fourier transform infrared spectroscopies

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 115362 - 115362

Опубликована: Янв. 1, 2025

Язык: Английский

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Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161732 - 161732

Опубликована: Март 1, 2025

Язык: Английский

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Bridging the gap: how patient-derived lung cancer organoids are transforming personalized medicine

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Апрель 15, 2025

Lung cancer is a major malignancy that poses significant threat to human health, with its complex pathogenesis and molecular characteristics presenting substantial challenges for treatment. Traditional two-dimensional cell cultures animal models are limited in their ability accurately replicate the of different lung patients, thereby hindering research on disease mechanisms treatment strategies. The development organoid technology has enabled growth patient-derived tumor cells three-dimensional cultures, which can stably preserve tumor’s tissue morphology, genomic features, drug response. There have been advancements field organoids (PDLCOs), remain reproducibility standardization PDLCOs due variations specimen sources, subsequent processing techniques, culture medium formulations, Matrigel batches. This review summarizes cultivation validation processes explores clinical applications personalized treatment, screening after resistance, biobanks construction, development. Additionally, integration cutting-edge technologies various fields, such as assembloid artificial intelligence, organoid-on-a-chip, 3D bioprinting, gene editing, single-cell RNA sequencing, greatly expanded potential. review, incorporating latest developments PDLCOs, provides an overview cultivation, applications, interdisciplinary integration, while also addressing prospects precision medicine cancer.

Язык: Английский

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Recent advances in graphitic carbon nitride-based heterojunction for biomedical applications

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157464 - 157464

Опубликована: Ноя. 1, 2024

Язык: Английский

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