Enabling technologies for in situ biomanufacturing using probiotic yeast

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115605 - 115605

Опубликована: Май 1, 2025

Saccharomyces boulardii (Sb) is a Generally Regarded As Safe (GRAS) probiotic yeast currently used to alleviate symptoms from various gastrointestinal diseases. Sb promising platform for and biotherapeutic engineering as it the only eukaryote carries with unique set of advantages compared bacterial strains, including resistance phage, high protein secretion abilities, intrinsic antibiotics. While engineered has not been studied extensively its close relative cerevisiae (Sc), many genetic tools developed Sc have also shown promise in Sb. In this review, we address recent research develop engineering, colonization modulation, biomarker sensing, drug production Ongoing efforts, especially those that overcome gut-specific challenges performance, are highlighted they advance chassis scalable treating

Язык: Английский

Advanced microbiome therapeutics for oral delivery of peptides and proteins: Advances, challenges, and opportunities

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115603 - 115603

Опубликована: Май 1, 2025

Язык: Английский