Energy Metabolism and Stemness and the Role of Lauric Acid in Reversing 5-Fluorouracil Resistance in Colorectal Cancer Cells
Rina Fujiwara‐Tani,
Yi Luo,
Ruiko Ogata
и другие.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 664 - 664
Опубликована: Янв. 14, 2025
While
5-fluorouracil
(5FU)
plays
a
central
role
in
chemotherapy
for
colorectal
cancer
(CRC),
resistance
to
5FU
remains
major
challenge
CRC
treatment,
and
its
underlying
mechanisms
remain
unclear.
In
this
study,
we
investigated
the
relationship
between
acquisition,
stemness,
energy
metabolism.
Among
two
cell
lines,
HT29
cells
exhibited
glycolytic
quiescent
properties,
while
CT26
relied
on
oxidative
phosphorylation
(OXPHOS)
energy.
contrast,
5FU-resistant
sublines
(HT29R
CT26R),
developed
through
continuous
exposure
low
concentrations
of
5FU,
demonstrated
enhanced
stemness.
This
was
associated
with
dominance,
proliferation,
reduced
reactive
oxygen
species
(ROS)
production.
However,
treatment
medium-chain
fatty
acid
lauric
shifted
OXPHOS,
reducing
increasing
ROS
levels,
inducing
death,
therefore
reversing
resistance.
These
findings
suggest
that
an
enhancement
stemness
reprogramming
metabolism
play
key
roles
acquiring
CRC.
reversed
resistance,
further
clinical
studies
are
required.
Язык: Английский
Photobiomodulation mitigates doxorubicin resistance in MDA-MB-231 breast cancer cells: a promising avenue for overcoming chemoresistance
Lasers in Medical Science,
Год журнала:
2025,
Номер
40(1)
Опубликована: Фев. 4, 2025
Язык: Английский
The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Язык: Английский