Human Brain Mapping,
Год журнала:
2021,
Номер
42(11), С. 3680 - 3711
Опубликована: Май 20, 2021
Abstract
Graph
theory
is
now
becoming
a
standard
tool
in
system‐level
neuroscience.
However,
endowing
observed
brain
anatomy
and
dynamics
with
complex
network
representation
involves
often
covert
theoretical
assumptions
methodological
choices
which
affect
the
way
networks
are
reconstructed
from
experimental
data,
ultimately
resulting
properties
their
interpretation.
Here,
we
review
some
fundamental
conceptual
underpinnings
technical
issues
associated
reconstruction,
discuss
how
mutual
influence
concurs
clarifying
organization
of
function.
Brain,
Год журнала:
2019,
Номер
142(4), С. 1024 - 1034
Опубликована: Янв. 31, 2019
Using
a
dynamic
graph
theoretical
approach,
Shine
et
al.
show
that
individuals
with
Parkinson’s
disease
demonstrate
heightened
network-level
integration
during
the
‘Off’
state
is
inversely
correlated
motor
symptom
severity.
Network-level
relates
to
two
measures
of
neurocognitive
reserve,
suggesting
protective
function
for
integration.
Journal of Alzheimer s Disease,
Год журнала:
2017,
Номер
59(4), С. 1381 - 1392
Опубликована: Июль 18, 2017
Reserve
in
aging
and
Alzheimer's
disease
(AD)
is
defined
as
maintaining
cognition
at
a
relatively
high
level
the
presence
of
neurodegeneration,
an
ability
often
associated
with
higher
education
among
other
life
factors.Recent
evidence
suggests
that
resting-state
functional
connectivity
within
frontoparietal
control
network,
specifically
left
frontal
cortex
(LFC)
hub,
contributes
to
reserve.Following
up
these
previous
fMRI
findings,
we
probed
memory-task
related
LFC
hub
neural
substrate
reserve.In
elderly
controls
(CN,
n
=
37)
patients
mild
cognitive
impairment
(MCI,
17),
assessed
global
during
successful
face-name
association
learning,
using
generalized
psychophysiological
interaction
analyses.Reserve
was
quantified
residualized
memory
performance,
accounted
for
gender
proxies
neurodegeneration
(age,
hippocampus
atrophy,
APOE
genotype).We
found
greater
LFC-connectivity
both
CN
MCI
memory.Furthermore,
predicted
(i.e.,
reserve).These
results
suggest
reserve
healthy
pathological
aging.
Human Brain Mapping,
Год журнала:
2018,
Номер
39(12), С. 4802 - 4819
Опубликована: Июль 27, 2018
Abstract
The
role
of
cerebellum
and
cerebro‐cerebellar
system
in
neural
plasticity
induced
by
cerebral
gliomas
involving
language
network
has
long
been
ignored.
Moreover,
whether
or
not
the
process
reorganization
is
different
glioma
patients
with
growth
kinetics
remains
largely
unknown.
To
address
this
issue,
we
utilized
preoperative
structural
resting‐state
functional
MRI
data
78
left
areas,
including
46
low‐grade
(LGG,
WHO
grade
II),
32
high‐grade
(HGG,
III/IV),
44
healthy
controls.
Spontaneous
brain
activity,
connectivity
gray
matter
volume
alterations
were
examined.
We
found
that
both
LGG
HGG
exhibited
bidirectional
alteration
activity
language‐related
cerebellar
areas.
Brain
areas
increased
was
significantly
correlated
MMSE
scores.
Structurally,
greater
regions
suggesting
a
structure–function
coupled
cerebellum.
Furthermore,
observed
decreased
contralesional
patients.
Together,
our
findings
provide
empirical
evidence
for
vital
circuit
following
lesional
damage
to
network.
highlight
possible
reorganizational
mechanisms
underlying
levels
behavioral
impairments
Journal of Alzheimer s Disease,
Год журнала:
2019,
Номер
69(4), С. 1137 - 1151
Опубликована: Май 20, 2019
Repetitive
transcranial
magnetic
stimulation
(rTMS)
is
thought
to
be
effective
in
alleviating
cognitive
symptoms
patients
with
amnestic
mild
impairment
(aMCI),
but
the
mechanisms
related
network
modification
are
poorly
understood.
Here
we
tested
rTMS
efficacy
and
explored
effect
of
rTMS-induced
changes
default
mode
(DMN)
their
predictive
value
for
treatment
response.
Twenty-one
subjects
clinically
diagnosed
aMCI
were
recruited
complete
a
10-session
randomized
sham-controlled
targeting
right
dorsolateral
prefrontal
cortex.
Resting-state
functional
resonance
imaging
tandem
neuropsychological
assessments
administered
before
after
intervention.
Changes
connectivity
DMN
relevant
brain
regions,
as
well
correlations
between
baseline
clinical
rating
scales
calculated
order
elucidate
mechanism
response
therapy.
Compared
sham
group,
group
achieved
improvement
performance
significant
within
DMN.
Group×Time
interactions
found
posterior
cingulate
gyrus
fusiform
(F
(1,19)
=
17.154,
p
0.001),
also
left
anterior
3.908,
0.063),
showing
an
deactivation
Baseline
analysis
seeds
revealed
negative
correlation
AVLT-Recognition
score
changes.
hypoconnectivity
associated
improvements
aMCI.
Further,
pre-rTMS
activity
at
rest
may
predictor
favorable
Human Brain Mapping,
Год журнала:
2021,
Номер
42(11), С. 3680 - 3711
Опубликована: Май 20, 2021
Abstract
Graph
theory
is
now
becoming
a
standard
tool
in
system‐level
neuroscience.
However,
endowing
observed
brain
anatomy
and
dynamics
with
complex
network
representation
involves
often
covert
theoretical
assumptions
methodological
choices
which
affect
the
way
networks
are
reconstructed
from
experimental
data,
ultimately
resulting
properties
their
interpretation.
Here,
we
review
some
fundamental
conceptual
underpinnings
technical
issues
associated
reconstruction,
discuss
how
mutual
influence
concurs
clarifying
organization
of
function.
