bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Дек. 15, 2022
Abstract
Attention-deficit/hyperactivity
disorder
(ADHD)
is
characterized
by
a
continuum
of
symptoms
including
inattentiveness,
hyperfocus,
and
hyperactivity,
that
are
manifested,
e.g.
,
in
increased
reaction-time
variability
continuous
performance
tasks
(CPTs).
Framework
brain
criticality
posits
brains
operate
an
extended
regime
critical-like
dynamics
where
neuronal
behavioral
processes
exhibit
scale-free
long-range
temporal
correlations
(LRTCs)
across
hundreds
seconds.
Whether
shifts
states
parallel
changes
LRTCs
underlie
ADHD
has
remained
unexplored.
We
investigated
whether
brain-state
towards
excitation-dominated
associated
could
explain
their
individuals.
measured
activity
with
magnetoencephalography
(MEG)
during
resting
two
CPTs
from
adult
participants
diagnosed
(
N
=
34)
neurotypical
controls
(NC)
36)
oscillations.
patients
exhibited
stronger
than
NC
low
(5-20
Hz)
high
(30-100
frequencies
dichotomous
task
effects.
High-frequency
were
positively
correlated
symptoms,
while
beta-band
(20-30
quadratic
correlation,
peaking
at
moderate
scores
the
cohorts
being
smaller
for
scores.
demonstrate
resting-and
task-state
dynamics.
Individuals
intermediate
symptom
operated
peak
several
functional
benefits
The
progressive
shift
supercritical
side
critical
becomes
detrimental
only
severe
symptoms.
Advances in Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
33(4), С. 321 - 326
Опубликована: Март 21, 2024
A
harmonic
brain-body
communication
is
fundamental
to
individual
wellbeing
and
the
basis
of
human
cognition
behavior.In
last
2
decades,
interaction
between
brain
body
functioning
has
become
a
central
area
study
for
neurologists
neuroscientists
in
clinical
non-clinical
contexts.Indeed,
axis
dysfunctions
occur
many
psychiatric,
neurological
neurodegenerative
diseases.This
editorial
will
focus
on
recent
advances
future
therapeutic
perspectives
studying
interactions
health
diseases.
Nature Medicine,
Год журнала:
2024,
Номер
30(12), С. 3646 - 3657
Опубликована: Авг. 26, 2024
Abstract
Brain
clocks,
which
quantify
discrepancies
between
brain
age
and
chronological
age,
hold
promise
for
understanding
health
disease.
However,
the
impact
of
diversity
(including
geographical,
socioeconomic,
sociodemographic,
sex
neurodegeneration)
on
brain-age
gap
is
unknown.
We
analyzed
datasets
from
5,306
participants
across
15
countries
(7
Latin
American
Caribbean
(LAC)
8
non-LAC
countries).
Based
higher-order
interactions,
we
developed
a
deep
learning
architecture
functional
magnetic
resonance
imaging
(2,953)
electroencephalography
(2,353).
The
comprised
healthy
controls
individuals
with
mild
cognitive
impairment,
Alzheimer
disease
behavioral
variant
frontotemporal
dementia.
LAC
models
evidenced
older
ages
(functional
imaging:
mean
directional
error
=
5.60,
root
square
(r.m.s.e.)
11.91;
electroencephalography:
5.34,
r.m.s.e.
9.82)
associated
frontoposterior
networks
compared
models.
Structural
socioeconomic
inequality,
pollution
disparities
were
influential
predictors
increased
gaps,
especially
in
(
R
²
0.37,
F
0.59,
6.9).
An
ascending
to
impairment
was
found.
In
LAC,
observed
larger
gaps
females
control
groups
respective
males.
results
not
explained
by
variations
signal
quality,
demographics
or
acquisition
methods.
These
findings
provide
quantitative
framework
capturing
accelerated
aging.
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
20(5), С. 3228 - 3250
Опубликована: Март 19, 2024
Alzheimer's
disease
(AD)
and
behavioral
variant
frontotemporal
dementia
(bvFTD)
lack
mechanistic
biophysical
modeling
in
diverse,
underrepresented
populations.
Electroencephalography
(EEG)
is
a
high
temporal
resolution,
cost-effective
technique
for
studying
globally,
but
lacks
models
produces
non-replicable
results.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
157, С. 105510 - 105510
Опубликована: Дек. 15, 2023
The
cognitive
neuroscience
of
brain
diseases
faces
challenges
in
understanding
the
complex
relationship
between
structure
and
function,
heterogeneity
phenotypes,
lack
dimensional
transnosological
explanations.
This
perspective
offers
a
framework
combining
predictive
coding
theory
allostatic
interoceptive
overload
(PAIO)
intrinsic
neural
timescales
(INT)
to
provide
more
dynamic
health
psychiatry
neurology.
PAIO
integrates
allostasis
interoception
assess
interaction
internal
patterns
environmental
stressors,
while
INT
shows
that
different
regions
operate
on
timescales.
can
be
understood
as
failure
INT,
which
involves
breakdown
proper
temporal
integration
segregation.
lead
disbalances
exteroceptive/interoceptive
inputs
across
whole-body
levels
(cardiometabolic,
cardiovascular,
inflammatory,
immune).
approach
new
insights,
presenting
novel
perspectives
spatiotemporal
hierarchies
interactions.
By
integrating
these
theories,
paper
opens
innovative
paths
for
studying
dynamics,
inform
future
research
disease.
iScience,
Год журнала:
2025,
Номер
28(2), С. 111918 - 111918
Опубликована: Фев. 1, 2025
Dr.
Agustin
Ibanez
joins
iScience
editor
Maryam
Fard
to
discuss
his
personal
journey
in
brain
health
research.
He
advocates
for
integrating
diversity
neurodegeneration
studies,
crucial
understanding
conditions
like
dementia.
founded
ReDLat
and
BrainLat,
advancing
research
across
Latin
America
empowering
underrepresented
voices.
This
inspiring
discussion
showcases
commitment
fostering
interdisciplinary
approaches
drive
global
progress.
is
also
the
Guest
Editor
of
iScience's
Special
Issue:
"Transdisciplinary
arts
health:
Integrating
creative
practice
clinical
public
contexts."
