Methods, Год журнала: 2024, Номер 226, С. 1 - 8
Опубликована: Март 12, 2024
Язык: Английский
Molecular Cell, Год журнала: 2025, Номер 85(2), С. 276 - 289
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Theranostics, Год журнала: 2025, Номер 15(6), С. 2428 - 2450
Опубликована: Янв. 20, 2025
Rationale: Abnormal metabolic states contribute to a variety of diseases, including cancer. RNA modifications have diverse biological functions and are implicated in cancer development, gastric (GC). However, the direct relationship between glucose homeostasis 4-acetylcytosine (ac4C) modification GC remains unclear. Methods: The prognostic value acetyltransferase NAT10 expression was evaluated human cohort. Additionally, preoperative PET/CT data from patients Micro-PET/CT imaging mice were employed assess metabolism. role investigated through various experiments, xenografts, organoids, conditional knockout (cKO) mouse model. underlying mechanisms examined using dot blotting, immunofluorescence staining, co-immunoprecipitation, high-throughput sequencing, among other techniques. Results: Glucose deprivation activates autophagy-lysosome pathway, leading degradation by enhancing its interaction with sequestosome 1 (SQSTM1)/microtubule-associated protein light chain 3 alpha (LC3) complex, ultimately resulting reduction ac4C modification. Furthermore, levels elevated tissues correlate poor prognosis. A strong correlation exists 18F-FDG uptake patients. drives glycolytic metabolism carcinogenesis vitro vivo. Mechanistically, stimulates at intersection coding sequence (CDS) 3' untranslated region (3'UTR) hexokinase 2 (HK2) mRNA, stability activating thereby driving tumorigenesis. Conclusion: Our findings highlight critical crosstalk epitranscriptome carcinogenesis. This finding offers potential strategy targeting NAT10/HK2 axis for treatment patients, especially those highly active
Язык: Английский
Процитировано
2
MedComm, Год журнала: 2025, Номер 6(1)
Опубликована: Янв. 1, 2025
Abstract RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such N6‐methyladenosine (m 6 A) 5‐methylcytosine 5 C), implicated in various cellular processes. These regulated by proteins write, erase, read modulate stability, splicing, translation, degradation. Recent studies have highlighted their roles metabolic reprogramming, signaling pathways, cell cycle control, which essential for tumor proliferation survival. Despite these scientific advances, the precise mechanisms affect remain inadequately understood. This review comprehensively examines role play proliferation, metastasis, programmed death, including apoptosis, autophagy, ferroptosis. It explores effects on epithelial–mesenchymal transition (EMT) immune microenvironment, particularly metastasis. Furthermore, modifications’ potential therapies, conventional treatments, immunotherapy, targeted is discussed. By addressing aspects, this aims to bridge current research gaps underscore therapeutic of targeting improve treatment strategies patient outcomes.
Язык: Английский
Процитировано
1
Drug Resistance Updates, Год журнала: 2025, Номер unknown, С. 101241 - 101241
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Март 31, 2025
Abstract Protein post-translational modifications (PTMs) refer to covalent and enzymatic alterations folded or nascent proteins during after protein biosynthesis alter the properties functions of proteins. PTMs are modified in a variety types affect almost all aspects cell biology. have been reported be involved cancer progression by influencing multiple signaling pathways. The mechanism action histone has extensively studied. Notably, evidence is mounting that non-histone also play vital role progression. In this review, we provide systematic description main associated with progression, including acetylation, lactylation, methylation, ubiquitination, phosphorylation, SUMOylation, based on recent studies.
Язык: Английский
Процитировано
1
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 3, 2025
Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms. Among epigenetic factors, m5C RNA modification is emerging as key player drug resistance, similar to the well-known m6A modification. affects metabolism processes, including splicing, export, translation, and stability, thereby influencing efficacy. This review highlights critical roles modulating chemotherapy, targeted therapy, radiotherapy, immunotherapy. also discusses functions regulators, methyltransferases, demethylases, m5C-binding proteins, essential modulators landscape that contribute dynamic regulatory network. Targeting these components offers promising strategy overcome resistance. We highlight need for further research elucidate specific mechanisms by which contributes develop precise m5C-targeted therapies, presenting m5C-focused strategies potential novel anticancer treatments.
Язык: Английский
Процитировано
1
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Дек. 6, 2023
Abstract Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one most common modifications widely observed eukaryotes prokaryotes. Accumulating studies have revealed that affects occurrence development various tumors. In recent years, has been shown to play an important role regulating tumor angiogenesis. this review, we mainly elucidate mechanisms functions on progression several cancers. We then shed light methylation-associated factors pathways Finally, describe as potential biomarker novel therapeutic target.
Язык: Английский
Процитировано
21
British Journal of Cancer, Год журнала: 2023, Номер 129(1), С. 8 - 23
Опубликована: Март 30, 2023
Язык: Английский
Процитировано
20
International Journal of Molecular Sciences, Год журнала: 2023, Номер 25(1), С. 24 - 24
Опубликована: Дек. 19, 2023
Cancer was initially attributed to genetic mutations and gene alterations, which resemble diseases caused by various modifications of a specific in the genome sequence [...].
Язык: Английский
Процитировано
19
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 17, 2024
Abstract N 4 -acetylcytidine (ac C) is a highly conserved chemical modification widely found in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, mRNA. This significantly associated with various human diseases, especially cancer, its formation depends on the catalytic activity of N-acetyltransferase 10 (NAT10), only known protein that produces ac C. review discusses detection techniques regulatory mechanisms C summarizes correlation tumor occurrence, development, prognosis, drug therapy. It also comments new biomarker for early diagnosis prognosis prediction target
Язык: Английский
Процитировано
8