Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving DOI
Sophia J. Weber, Alex B. Kawa, Alana L Moutier

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 30, 2024

Relapse represents a consistent clinical problem for individuals with substance use disorder. In the incubation of craving model persistent and relapse, cue-induced drug seeking progressively intensifies or 'incubates' during first weeks abstinence from self-administration then remains high months. Previously, we others have demonstrated that expression incubated cocaine requires strengthening excitatory synaptic transmission in nucleus accumbens core (NAcc). However, despite importance dopaminergic signaling NAcc motivated behavior, little is known about role dopamine (DA) plays craving. Here used fiber photometry to measure DA transients male female rats tests conducted early self-administration, prior incubation, late abstinence, after has plateaued. We observed time-locked responding but their magnitude did not differ significantly when measured versus tests. Next, tested functional these by injecting receptor antagonists into just before test. Blockade either D1 D2 receptors reduced incubation. found no main effect sex our experiments. These results suggest contributes emergence this reflects changes postsynaptic responsiveness rather than presynaptic alterations.

Язык: Английский

Looming stimuli reliably drive innate defensive responses in male rats, but not learned defensive responses DOI Creative Commons
Mirjam Heinemans, Marta A. Moita

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 16, 2024

Survival relies on an organism's intrinsic ability to instinctively react stimuli such as food, water, and threats, ensuring the fundamental feed, drink, avoid danger even in absence of prior experience. These natural, unconditioned can also facilitate associative learning, where pairing them consistently with neutral cues will elicit responses these cues. Threat conditioning, a well-explored form commonly employs painful electric shocks, mimicking injury, stimuli. It remains elusive whether actual injury or pain is necessary for effective threat harm sufficient. Approaching predators create looming shadows sounds, triggering strong innate defensive like escape freezing. This study investigates visual induce learned freezing conditioned stimulus male rats. Surprisingly, tone only weakly evokes responses, contrast observed when replaced by shock. dissociation sheds light boundaries thereby impacting our comprehension learning processes strategies.

Язык: Английский

Процитировано

3
Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving DOI
Sophia J. Weber, Alex B. Kawa,

Madelyn M Beutler

и другие.

Neuropsychopharmacology, Год журнала: 2024, Номер 50(2), С. 461 - 471

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

3
Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum DOI Open Access
Aske L. Ejdrup,

Jamin Dreyer,

Matthew D. Lycas

и другие.

Опубликована: Фев. 17, 2025

Striatal dopamine (DA) release regulates reward-related learning and behavioural activation is believed to consist of a short-lived phasic continuous tonic component. Here, we build three-dimensional model extracellular DA dynamics in dorsal (DS) ventral striatum (VS) that include tens thousands sites. The predicts rapid DS with little-to-no basal DA, much slower the VS enabling build-up level. These regional differences do not primarily reflect different phenomena but rather arise from differential transporter (DAT) activity. Interestingly, our simulations posit prevalent nanoclustering DAT as possible regulator this Receptor binding show D1 receptor occupancy follows concentration millisecond delay, while D2 receptors integrate signal over seconds. Summarized, distills recent experimental observations into computational framework challenge prevailing paradigms striatal signalling.

Язык: Английский

Процитировано

0
Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum DOI Open Access
Aske L. Ejdrup,

Jamin Dreyer,

Matthew D. Lycas

и другие.

Опубликована: Фев. 17, 2025

Striatal dopamine (DA) release regulates reward-related learning and behavioural activation is believed to consist of a short-lived phasic continuous tonic component. Here, we build three-dimensional model extracellular DA dynamics in dorsal (DS) ventral striatum (VS) that include tens thousands sites. The predicts rapid DS with little-to-no basal DA, much slower the VS enabling build-up level. These regional differences do not primarily reflect different phenomena but rather arise from differential transporter (DAT) activity. Interestingly, our simulations posit prevalent nanoclustering DAT as possible regulator this Receptor binding show D1 receptor occupancy follows concentration millisecond delay, while D2 receptors integrate signal over seconds. Summarized, distills recent experimental observations into computational framework challenge prevailing paradigms striatal signalling.

Язык: Английский

Процитировано

0
Dopamine and calcium dynamics in the nucleus accumbens core during food seeking DOI Creative Commons
Sophia J. Weber, Gillian S. Driscoll,

Madelyn M Beutler

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract Extinction-reinstatement paradigms have been used to study reward seeking for both food and drug rewards. The nucleus accumbens is of particular interest in reinstatement due its ability energize motivated behavior. Indeed, previous work has demonstrated that suppression neuronal activity or dopaminergic signaling the reduces seeking. In this study, we sought further establish a connection between glutamatergic input, measured by proxy via genetically encoded calcium indicator, dopamine (DA) tone, simultaneously with red-shifted DA biosensor. We performed sensor multiplexing core classic extinction-reinstatement paradigm reward. detected transients changed magnitude and/or temporally shifted over course self-administration training. our traces observed decrease from baseline time-locked lever press reward, which became more prominent Both patterns were reduced first session extinction no deflections either last session. When recorded during tests, bootstrapping analysis response when was primed cue pellet+cue presentation, while reinstatement. These data role represent attempt record two an task.

Язык: Английский

Процитировано

0
The learning primacy hypothesis of dopamine: reconsidering dopamine’s dual functions DOI Creative Commons
Charltien Long, Sotiris C. Masmanidis

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 15, 2025

The dopaminergic modulation of striatal circuit function remains intensely studied and debated. Nevertheless, a prevalent view is that dopamine serves important roles in both reinforcement learning the performance movements, two highly distinct processes. But this dichotomy has led to longstanding problem how interpret functional consequences particular signal—is it learn or move? In order explore ambiguity approach possible resolution, review examines key evidence for dopamine’s role movement. As part discussion, we consider recent body views common dichotomous perspective through more nuanced lens, by suggesting comparatively limited contribution This concept, which refer as primacy hypothesis, offers unified conceptual framework understanding function.

Язык: Английский

Процитировано

0
Refining the role of the paraventricular hypothalamus in feeding behavior DOI Creative Commons
Lisa Z. Fang, Michiru Hirasawa

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(19)

Опубликована: Май 5, 2025

Язык: Английский

Процитировано

0
Neuromodulatory processing in the bi-pathway brain architecture DOI Creative Commons
Funing Li, Changmei Zhang, Jiulin Du

и другие.

Current Opinion in Neurobiology, Год журнала: 2025, Номер 93, С. 103055 - 103055

Опубликована: Май 23, 2025

Язык: Английский

Процитировано

0
Coding principles of dopaminergic transmission modes DOI Creative Commons
Limeng Huang, Yuanyu Chang, Zhipeng Yang

и другие.

Science Advances, Год журнала: 2025, Номер 11(22)

Опубликована: Май 28, 2025

Dopaminergic neurons influence diverse behaviors with varied firing patterns, yet the precise mechanisms remain unclear. We introduce a multiplexed genetically encoded sensor–based imaging and voltammetry method to simultaneously record synaptic, perisynaptic, extrasynaptic dopaminergic transmission at mouse central neurons. Using this alongside image analysis program, we found that heterogeneous patterns create various modes, encoding frequency, number, synchrony of pulses using neurotransmitter quantity, releasing synapse count, synaptic and/or volume transmission. Under both tonic low-frequency phasic activities, transporters effectively reuptake dopamine perisynaptic sites, confining within clefts mediate In contrast, under high-frequency, particularly synchronized activity or transporter inhibition, released may overwhelm transporters, escaping from via one three outlet channels, triggering Our study illuminates collaborative mechanism enclosures, properties, defines coding principles pattern–dependent modes.

Язык: Английский

Процитировано

0
Application of MXene in the Electrochemical Detection of Neurotransmitters: A Review DOI
Ajith Mohan Arjun,

Megha Shinde,

Gymama Slaughter

и другие.

IEEE Sensors Journal, Год журнала: 2023, Номер 23(15), С. 16456 - 16466

Опубликована: Июнь 19, 2023

Neurotransmitters are small chemical signaling molecules crucial for the proper function of nervous system. The dysregulation neurotransmitters results in several mental disorders like Parkinson's and Alzheimer's diseases, schizophrenia, conditions such as depression addiction. These present at low concentrations, obtaining information about these molecules' levels is vital. Moreover, neurotransmitter monitoring system remains challenging due to its concentrations rapid response. Electrochemical detection continues garner significant attention an attractive technique facile nature, high sensitivity, cost-effectiveness. electroactive materials electrochemical sensors heart this sensing technology. Although multiple nanomaterials have been explored active components detecting neurotransmitters, MXenes gaining neurotransmitters. This review aims discuss use their composites describe various MXene based on nature composite viz pristine functionalized, carbon nanomaterial, polymer, metal nanoparticle, transition dichalcogenide (TMDC) composites, define future directions leveraging properties early-stage neurological diseases originating from imbalance

Язык: Английский

Процитировано

8