Behavioural Brain Research, Год журнала: 2023, Номер 461, С. 114831 - 114831
Опубликована: Дек. 22, 2023
Язык: Английский
The Lancet Diabetes & Endocrinology, Год журнала: 2023, Номер 11(12), С. 926 - 941
Опубликована: Окт. 18, 2023
Язык: Английский
Процитировано
57
Nature Neuroscience, Год журнала: 2024, Номер 27(11), С. 2253 - 2260
Опубликована: Сен. 16, 2024
Abstract Pregnancy is a period of profound hormonal and physiological changes experienced by millions women annually, yet the neural unfolding in maternal brain throughout gestation are not well studied humans. Leveraging precision imaging, we mapped neuroanatomical an individual from preconception through 2 years postpartum. Pronounced decreases gray matter volume cortical thickness were evident across brain, standing contrast to increases white microstructural integrity, ventricle cerebrospinal fluid, with few regions untouched transition motherhood. This dataset serves as comprehensive map human gestation, providing open-access resource for imaging community further explore understand brain.
Язык: Английский
Процитировано
23
Exercise and Sport Sciences Reviews, Год журнала: 2024, Номер 52(2), С. 54 - 62
Опубликована: Фев. 8, 2024
Males and females experience different trajectories of neuromuscular function across the lifespan, with demonstrating accelerated deconditioning in later life. We hypothesize that menopause is a critical period female during which dramatic reduction sex hormone concentrations negatively impacts synaptic input to motoneuron pool, as well motor unit discharge properties.
Язык: Английский
Процитировано
12
Psychological Medicine, Год журнала: 2025, Номер unknown, С. 1 - 12
Опубликована: Янв. 14, 2025
Racial, ethnic, and socioeconomic disparities persist in posttraumatic stress disorder (PTSD), which are partly attributed to minoritized women being trauma-exposed, while also contending with harmful contextual stressors. However, few have used analytic strategies that capture the interplay of these experiences their relation PTSD. The current study a person-centered statistical approach examine heterogeneity trauma exposure, associations PTSD underlying symptom dimensions, diverse sample low-income postpartum women. Using community-based Black, Hispanic/Latina, White recruited from five U.S. regions (n = 1577), latent class analysis generated profiles past-year exposure traumatic events at one month postpartum. Regression analyses then examined between membership severity six months as function race/ethnicity. A four-class solution best fit data, yielding High Contextual Stress, Injury/Illness, Violence Exposure, Low Trauma/Contextual Stress classes. Compared class, any other classes was associated greater across nearly all dimensions (all ps < 0.05). Additionally, constellations exposures were differentially linked total severity, reexperiencing, numbing symptoms racial/ethnic groups (ps can diverse, Moreover, racially/ethnically patterned links or stressful implications for screening intervention perinatal period.
Язык: Английский
Процитировано
1
Brain Behavior and Immunity, Год журнала: 2024, Номер 120, С. 54 - 70
Опубликована: Май 19, 2024
Язык: Английский
Процитировано
6
Nature Mental Health, Год журнала: 2024, Номер 2(11), С. 1308 - 1317
Опубликована: Окт. 28, 2024
Язык: Английский
Процитировано
5
Open Biology, Год журнала: 2023, Номер 13(11)
Опубликована: Ноя. 1, 2023
Pregnancy is marked by robust changes, including brain changes to volume, structure, connectivity and neuroplasticity. Although some are restricted pregnancy the postpartum, others long-lasting. Few studies have examined possible mechanisms of these or effects multiple pregnancies. We characterized various cellular molecular signatures parity (nulliparous, primiparous, biparous) in rat hippocampus. investigated density neural stems cells (Sox2), microglia (Iba-1) levels a synaptic protein (PSD-95), cell signalling pathways, neuroinflammation, tryptophan-kynurenine (TRP-KYN) pathway, one week after weaning their pups from last (age dam: seven months) middle-age 13 months). Parity increased PSD-95 both age groups prevented age-related decrease stem observed nulliparous rats. Biparity phosphoproteins (pp70S6K, S6RP) number dentate gyrus, regardless age. resulted transient TRP-KYN system. Thus, previous has lasting on plasticity with fewer inflammation whole
Язык: Английский
Процитировано
13
Nature Mental Health, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Abstract Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, brain dynamics underlying this relationship are poorly understood. Here, address issue, we analyzed multimodal data from female participants in Adolescent Brain Cognitive Development (longitudinal, N = 441; aged 9–12 years) Human Connectome-Aging (cross-sectional, 130; 36–60 studies. Age-specific intrinsic functional network mediated link between perceptions of greater interpersonal adversity. The adolescent profile overlapped areas glutamatergic dopaminergic receptor density, middle-aged was concentrated visual, attentional default mode networks. two profiles showed opposite relationships with patterns neural variability cortical atrophy observed psychosis versus major depressive disorder. Our findings underscore divergent maturation senescence, which may explain developmentally specific vulnerabilities distinct disorders.
Язык: Английский
Процитировано
0
Frontiers in Neuroendocrinology, Год журнала: 2025, Номер 77, С. 101185 - 101185
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0
Journal of Health Psychology, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
“Mom brain” is a commonly reported phenomenon in pregnant and postpartum women characterized by brain fog, forgetfulness, distractibility, other cognitive disruptions. However, research on objective functioning inconclusive does not necessarily align with mothers’ subjective experiences mom brain. This review discusses recent developments the perinatal neuroscience literature that support revised narrative which “mom conceptualized as period of functionally adaptive enhancements. Changing can shift societal expectations for mothers, thereby reducing social pressure negative self-evaluation to ultimately enhance across period.
Язык: Английский
Процитировано
0